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p-Index From 2021 - 2026
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All Journal Journal of Educational Innovation and Public Health
Intan Nova Kaesa
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Review Artikel: Pengaruh Jenis Eksipien terhadap Disolusi Tablet Najma Kamila Zahra; Intan Nova Kaesa; Elina Jatindria; Stella Reflya Pramudita; Dzikrina Adibah Salma
Journal of Educational Innovation and Public Health Vol. 4 No. 3 (2026): Juli: Journal of Educational Innovation and Public Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i3.9261

Abstract

This study aimed to analyze the effect of excipient variations on tablet dissolution profiles and the underlying mechanisms. The research method used was a literature review by examining scientific articles published between 2021 and 2026. Literature sources were obtained from Google Scholar, ResearchGate, and relevant national and international journals. The analysis was conducted descriptively and comparatively on the use of excipients such as binders, disintegrants, lubricants, and surfactants in tablet formulations and their effects on dissolution parameters. The review results showed that the type of excipient significantly affects the dissolution profile of tablets. Binders can improve the mechanical strength of tablets but may slow down dissolution, while disintegrants accelerate tablet disintegration and increase the dissolution rate. Lubricants such as magnesium stearate may inhibit liquid penetration due to their hydrophobic properties, whereas surfactants can enhance drug solubility and accelerate the dissolution process. In addition, the concentration and combination of excipients also influence porosity, tablet hardness, wettability, and drug release mechanisms. Therefore, the selection and optimization of excipients are crucial in developing tablet formulations with optimal dissolution profiles and therapeutic effectiveness.
Perbandingan Formulasi dan Uji Aktivitas Sun Protection Factor (SPF) Sediaan Lotion dari Berbagai Ekstrak Daun secara Spektrofotometri: Literatur Review Elina Jatindria; Intan Nova Kaesa; Mutiara Eka Putri; Selvi Iswandari; Aldo Octavian Ramadhan Saputra
Journal of Educational Innovation and Public Health Vol. 4 No. 3 (2026): Juli: Journal of Educational Innovation and Public Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i3.9275

Abstract

This systematic literature review aims to evaluate the formulation characteristics and Sun Protection Factor (SPF) activity of lotions containing various plant leaf extracts, which were tested in vitro using UV-Vis spectrophotometry. Exposure to ultraviolet (UV) radiation can cause various skin disorders, such as redness, premature aging, and an increased risk of skin cancer. With the growing interest in natural cosmetics, plant extracts containing flavonoids, phenolics, and tannins are increasingly being developed as active ingredients in natural sunscreens. Used in the final formulation. The study results indicate that leaf extracts from several plants, such as Nephelium lappaceum, Muntingia calabura, Crassocephalum crepidioides, and Carica papaya, possess UV-absorbing capabilities that are influenced by the extract concentration in the formulation. The most commonly used lotion formulation is an oil-in-water (O/W) emulsion with a combination of emulsifiers such as stearic acid and triethanolamine, which play a role in maintaining the physical stability, pH, viscosity, spreadability, and homogeneity of the preparation. The resulting SPF values vary, with the highest value approaching 30 in the 10% rambutan leaf (Nephelium lappaceum) extract lotion, placing it in the ultra-protection category. The UV-protective activity of the leaf extract is believed to be related to its polyphenol content, which can absorb UV radiation and help reduce sunburn. Based on the study results, the leaf extract-based lotion has the potential to be developed as a natural sunscreen. However, further research is still needed, particularly in vivo testing, irritation testing, photostability testing, and long-term stability testing to ensure the safety, efficacy, and stability of the formulation.
Co-Authors Aldo Octavian Ramadhan Saputra Dzikrina Adibah Salma Elina Jatindria Mutiara Eka Putri Najma Kamila Zahra Selvi Iswandari Stella Reflya Pramudita