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All Journal Sains Medisina Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Mulia Maharani
Universitas Anwar Medika
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Review Artikel: Analisis Formulasi Dan Evaluasi Tablet Effervescent Dengan Metode Granulasi Basah Fina Salsabila Nur Aini; Iftitah Nakhlah Sani; Seylin Zavira Ananta; Auliya Ika Putri; Anisa Khanif Khusnia; Ryan Satria Pranata; Mulia Maharani; Dewi Rahmawati; Dzakiya Dzihrotulwida
Sains Medisina Vol 4 No 5 (2026): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i5.1453

Abstract

Tablet effervescent merupakan salah satu bentuk sediaan farmasi yang banyak diminati karena praktis digunakan, memiliki rasa yang lebih dapat diterima, serta mampu larut dengan cepat dalam air sebelum dikonsumsi. Meskipun demikian, pengembangan tablet effervescent sering menghadapi kendala akibat sifat bahan penyusunnya yang mudah menyerap kelembapan dan rentan mengalami reaksi prematur. Salah satu metode yang banyak diterapkan untuk mengatasi permasalahan tersebut adalah granulasi basah karena dapat meningkatkan kualitas granul sebelum proses pencetakan tablet. Kajian ini bertujuan mengevaluasi berbagai penelitian terkait formulasi dan karakteristik fisik tablet effervescent yang dibuat menggunakan metode granulasi basah. Artikel dikumpulkan melalui penelusuran pustaka dari Google Scholar, Google, dan PubMed dengan rentang publikasi tahun 2021–2026. Hasil kajian menunjukkan bahwa penerapan granulasi basah mampu menghasilkan granul dengan kemampuan alir dan kompresibilitas yang baik sehingga mendukung terbentuknya tablet dengan mutu fisik yang memenuhi persyaratan. Perbedaan komposisi sumber asam, basa, maupun bahan pengikat terbukti memengaruhi karakteristik produk, seperti kekerasan, keseragaman bobot, kadar air, pH, dan waktu larut. Secara keseluruhan, metode granulasi basah dinilai efektif untuk menghasilkan tablet effervescent yang stabil, seragam, dan memiliki kualitas fisik yang baik.
Uji Aktivitas Farmakologi Buah Jambu Biji (Psidium guajava L.) Sepbrilla Ananda K; Mulia Maharani; Virgiawan Kusuma; Firlia Nur Afifah; Bella Fevi Aristia
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2341

Abstract

Guava (Psidium guajava L.) is a plant widely used in traditional medicine because it contains various bioactive compounds, such as flavonoids, phenolic compounds, tannins, alkaloids, terpenoids, lycopene, and vitamin C. These compounds are known to have various pharmacological activities that have the potential to support health. This opinion article aims to review and analyze the pharmacological activities of guava based on research results published in the period 2020–2025. The method used is a literature study of 11 national and international scientific journals selected according to the research topic. Data were analyzed descriptively by comparing findings regarding the biological activities of various plant parts, especially the fruit, fruit peel, and leaves. The results show that guava has various pharmacological activities, including antioxidant, antibacterial, antidiabetic, anticancer, anticholesterol, antimicrobial, and adaptogenic. Antioxidant activity is the most frequently reported effect, which is related to the high content of flavonoids, phenolic compounds, and vitamin C as free radical scavengers. Furthermore, several studies have shown that guava bioactive compounds can inhibit the activity of α-amylase and α-glucosidase enzymes, inhibit the growth of various pathogenic bacteria, and suppress the proliferation of cancer cells through various biological mechanisms. These findings indicate that guava has promising prospects for development as a raw material for herbal medicines and as a supportive therapy for various diseases. However, most of the available scientific evidence still comes from in vitro, in silico, and preclinical studies and therefore cannot be fully generalized to humans. Therefore, further research is needed, especially clinical trials with more comprehensive designs, to ensure the effectiveness, safety, optimal dosage, and potential use of guava in clinical practice.
Co-Authors Anisa Khanif Khusnia Auliya Ika Putri Bella Fevi Aristia Dewi Rahmawati Dzakiya Dzihrotulwida Fina Salsabila Nur Aini Firlia Nur Afifah Iftitah Nakhlah Sani Ryan Satria Pranata Sepbrilla Ananda K Seylin Zavira Ananta Virgiawan Kusuma