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Aktifitas Antioksidan dan Inhibitor Tirosinase Beberapa Stilbenoid dari Tumbuhan Moraceae dan Dipterocarpaceae yang Potensial untuk Bahan Kosmetik Didin Mujahidin; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawati
Jurnal Matematika & Sains Vol 13, No 2 (2008)
Publisher : Institut Teknologi Bandung

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Abstract

In a drug discovery program to combat various diseases, many natural chemicals originating from Indonesian tropicalplants including Moraceae and Dipterocarpaceae have been investigated in our laboratory. These family of plants areknown as rich sources of stilbenoid type of compounds which have been shown to have various bioactivities, that arepotentially important in cosmetic bioindustry. In the course of our search for bioactive natural products from plants, wewere interested in the stilbenoid constituents of these plants. Thus, as part of this program, several stilbene derivativeswere successfully isolated from extracts of Morus macroura, a Moraceous plant locally named andalas, includingoxyresveratrol (1), lunularin (2) and new resveratrol dimers, namely andalasin A (3) and andalasin B (4). While,biotransformation of oxyresveratrol (1) using cell suspension culture of Solanum mammosum affordedtrans-oxyresveratrol-4-O-β-D-glucopyranoside (5). Similarly, some resveratrol derivatives have been isolated fromDipterocarpaceous plants, such as Shorea assamica, S. seminis, Vatica umbonata, and Dryobalanops oblongifolia.These species gave, among others, resveratrol (6), resveratrol-12-C-β-glucopyranoside (7), the resveratrol dimers(-)-ε-viniferin (8) and the new compound diptoindonesin A (9), in addition to resveratrol trimers (-)-α-viniferin (10), thenew compounds cis-diptoindonesin B (11) and trans-diptoindonesin B (12). Among these compounds oxyresveratrol (1),andalasin B (4), trans-oxyresveratrol-4-O-β-D-glucopyranoside (5), resveratrol (6), cis-diptoindonesin B (11) andtrans-diptoindonesin B (12) exhibited the most potent antioxidant activity [1,1-diphenyl-2-picrylhydrazil (DPPH)radical-scavenging activity]; moreover, andalasin A (3) have been reported to show a very strong tirosinase inhibitoractivity, thus valuable in cosmetic industry.
Synthesis of 1-azabicyclo[3.2.2]nonane from cinchonidine Mujahidin, Didin; Hoffman, Hans Martin Rudolf
Jurnal Penelitian Teh dan Kina Vol 16, No 2 (2013)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.14 KB) | DOI: 10.22302/pptk.jur.jptk.v16i2.89

Abstract

The 1-azabicyclo[3.2.2]nonane is a potent building block which have important bio­logicaly activities including for Alzheimer and ashmatic treatment. The skeleton can be accessed by rearrangement of quinuclidine ring in Cinchona alkaloids. The rearrange­ment established three chiral center at C-2, C-3, and C-6. The rearrangement of qui­nuclidine moiety to azabicyclic[3.2.2]nonana system of mesylated cinchonidine took place by hydrolysis in a mixture of acetone–water (1:1) with 47% yields. The structure determination of the product and its absolute configuration of chiral centers were esta­blished by using spectroscopy data including, 1H NMR, 13C NMR, 1D NOE and HR-MS.
The oxidation reaction of quinine by potassium permanganate (KMnO4) Rosalina, Reny; Alni, Anita; Mujahidin, Didin; Santoso, Joko
Jurnal Penelitian Teh dan Kina Vol 18, No 2 (2015)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.892 KB) | DOI: 10.22302/pptk.jur.jptk.v18i2.76

Abstract

Quinine was known widely as malarial drug and a bitter taste ini soft drink. Recently, quinine have been also applied in organo-catalysis process, separation and purification of chiral compounds from enantiomeric mixture by diasteromeric salt crystallization and chiral chromatography. Quinine contains various functional groups which easily transforms by oxidations. This research was to study the oxi-dation reaction of quinine by using potassium permanganate (KMnO4) as oxidator. The KMnO4 oxidation carried out under acidic con-ditions. The separation and purification of pro-ducts were done by radial chromatography with chloroform : metanol : tri ethyl amine (9:1:0.1) as eluent. The structure of products were cha-racterized by spectroscopic data including: in-frared spectroscopy, NMR, and mass spectro-metry as quinine-1-N-oxide and quininal.
Synthesis of quinine N-oxide and an NMR tutorial in its structure determination Aisyah, Aisyah; Tamaela, Nila Berghuis; Santoso, Joko; Syah, Yana Maolana; Mujahidin, Didin
Jurnal Penelitian Teh dan Kina Vol 17, No 1 (2014)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.555 KB) | DOI: 10.22302/pptk.jur.jptk.v17i1.45

Abstract

Cinchona alkaloids are one of abundant natural chiral pool for organocatalysts. The application of an N-oxide group containing molecule in asymmetric reaction is currently wide developed. The structure of quinine consist two amine groups that could be oxidized to the N-oxide groups at N-1’ of quinoline and at N-1 of quinuclidine moieties. The oxidation reaction took place selectively at quinuclidine moiety by controlling the concentration of oxidizing agents. In this study we showed that N-1-oxide quinine could be occurred chemo­selectively by using a low concentration of ozone thana palladium catalyzed oxidation. The structure of products N1-oxide quinine was elucidated by spectroscopy data including 1H-NMR, 13C-NMR, 2D-NMR, infra-red and mass spectrometry. The developed method is a chemoselectively and eco-friendly method for synthesis N1-oxide quinine.
Encapsulation of Fe3O4 with amina modified silica Roswanda, Robby; Mujahidin, Didin
Jurnal Keramik dan Gelas Indonesia Vol 26, No 1 (2017): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

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Abstract

Superparamagnet iron oxide Fe3O4 particles were encapsulated with amina modified silica via Stober Method. The particles generated were rod-like whose length was c.a. 2 µm and the thickness of silica shell was c.a. 75 nm. Magnetization measurements show that the silica shell does not disrupt the superparamagnetic property of Fe3O4. The amine group on the encapsulated particles was confirmed by attaching FITC (Fluorescein isothiocyanate) dye and checked under fluorescence microscope. The encapsulated particle is useful to be modified further for various applications that need magnetic field control.
Studi Penggunaan Metil Ester Minyak Sawit Sebagai Minyak Isolasi Peralatan Listrik Rajab, Abdul; Pawawoi, Andi; Sulaeman, Aminudin; Mujahidin, Didin
JURNAL NASIONAL TEKNIK ELEKTRO Vol 3, No 1: Maret 2014
Publisher : Jurusan Teknik Elektro Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (798.354 KB) | DOI: 10.25077/jnte.v3n1.49.2014

Abstract

This paper discusses experimental results on some parameters of palm methyl ester as insulating oil. Destillations are firstly made to obtained the composition of oil that provide the optimal compromise among measured parameters. Breakdown voltage, dissipation factor, dielectric constant, viscosity and oxidation stability were then tested on original, destilled, and destillation residual oils. The results showed that the dissipation factor and viscosity of destilled palm methyl ester comply with the standard spesification for natural ester to be used as insulating oil. Sadly, the breakdown voltage and oxidation stability of oils do not fulfill the standard. However, the lower breakdown voltage of oils seem to be tolerable as their value are still higher then that of mineral oil. Dielectric constant of oils which were higher then that of mineral oil is an advantage when the oils will be used in combination with solid insulation for more uniformly field reason.                                                                                                         Key words : Methyl ester, breakdown voltage, dissipation factor, dielectric constant, viscosity, oxidation stability. AbstrakMakalah ini membahas beberapa parameter metil ester minyak sawit sebagai minyak isolasi. Destilasi dilakukan untuk mendapatkan komposisi minyak yang paling mungkin digunakan sebagai kandidat minyak isolasi. Minyak asli, hasil destilasi dan residu dari destilasi kemudian diuji beberapa parameternya seperti tegangan tembus, faktor disipasi, konstanta dielektrik, viskositas dan stabilitas oksidasi. Hasilnya menunjukkan bahwa faktor disipasi dan viskositas metil ester minyak sawit memenuhi standar sebagai minyak isolasi. Sayangnya tegangan tembus dan stabilitas oksidasinya termasuk kurang memadai. Namun demikian, tegangan tembusnya mungkin bisa ditolerir karena nilanya lebih baik dibanding minyak mineral. Konstanta dielektrik minyak yang lebih tinggi dibanding minyak mineral termasuk menguntungkan untuk keseragaman medan yang lebih baik saat penggunaan bersama dengan isolasi padat.Kata Kunci : Metil ester, tegangan tembus, faktor disipasi, konstanta dielektrik, viskositas, stabilitas oksidasi  
Sintesis Senyawa Berbasis Gadolinium Menggunakan Gliseril Monooleat Sebagai Ligan Dan Potensinya Sebagai Contrast Agents Teguh Hafiz Ambarwibawa; Didin Mujahidin
Jurnal Kimia dan Kemasan Vol. 41 No. 2 Oktober 2019
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v41i2.3850

Abstract

Magnetic Resonance Imaging (MRI) merupakan salah satu teknik diagnosis yang paling banyak digunakan di bidang kedokteran. Agar diperoleh visibilitas yang baik, digunakan contrast agents namun terkadang kontras yang dihasilkan masih rendah, sehingga diperlukan dosis contrast agents lebih tinggi agar diperoleh kontras optimum. Untuk mengatasi keterbatasan tersebut, dilakukan pembuatan contrast agents berbasis Gadolinium (Gd) menggunakan Gliseril Monooleat (GMO) sebagai ligan. Pada penelitian ini dilakukan sintesis GMO, kompleksasi Gd-GMO, pengukuran turbiditas mikroemulsi, serta pengukuran waktu relaksasi T2 GMO dan Gd-GMO menggunakan alat Nuclear Magnetic Resonance (NMR). Hasil sintesis 2,2-dimetil-1,3-dioksolana gliserol menghasilkan rendemen 82,6%, sedangkan dari hasil sintesis GMO diperoleh rendemen 94,2%. Hasil pengukuran waktu relaksasi T2, Gd-GMO menghasilkan waktu relaksasi T2 lebih rendah dibandingkan dengan GMO sebesar 15,4% sampai dengan 32,7%. Data waktu relaksasi T2 tersebut menunjukkan bahwa Gd-GMO berpotensi untuk digunakan sebagai contrast agents.
Synthesis of Eugenyl Cinnamate from Clove Oil (Syzygium aromaticum) via Bromination-Dehydrobromination Methods Anita Alni; Didin Mujahidin; Shinta Ellisya Fauzia
The Journal of Pure and Applied Chemistry Research Vol 8, No 2 (2019): Edition May-August 2019
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2019.008.02.458

Abstract

Synthesis of bioactive materials based on Indonesian natural products as precursors are potential to achieve a sustainable supply of modern medicines. Eugenyl cinnamate is a crucial building blocks in many bioactive compunds such as hepatoprotective silibinin. This research features simple synthesis of eugenyl cinnamate from eugenol, an essential oil presents as major constituent of clove oil (Syzygium aromaticum). The transformations were carried out via protection of hydroxyl group, bromination, and dehydrobromination reactions of eugenol (1) consecutively. The products of the synthesis were purified by gravity column chromatography and were characterized by FTIR and NMR spectroscopy. Benzylation of eugenol was carried out under basic condition with high yield (94.3%). Characterization by spectroscopic methods showed that eugenyl benzyl ether (2) was formed. Bromination of eugenyl benzyl ether yielded three products, namely: dibromo (3a and 3b), and tri-bromo eugenyl benzyl ether (3c). Compound 3a and 3b were epimers based on intensive NMR analysis (1H, 13C and DEPT). These epimers were separable using simple gravitational colomn chromatography. Bromination of eugenyl acetyl ether (4) yielded the targeted dibromo product (5). Dehydrobromination reaction of compound 5 with cinnamic acid yielded the eugenyl cinnamate (6) with yield of 23.2%. This compound is precursor in the hetero Diels-Alder reaction to form the dioxan unit of Silibinin. 
Thermal Characteristics Evaluation of Vegetables Oil to be Used as Phase Change Material in Air Conditioning System Yuli S. Indartono; Aryadi Suwono; Ari D. Pasek; Didin Mujahidin; Irfansyah Rizal
Jurnal Teknik Mesin (Sinta 3) Vol. 12 No. 2 (2010): OCTOBER 2010
Publisher : Institute of Research and Community Outreach, Petra Christian University

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Abstract

In a typical commercial building, air conditioning system consumes around 60% of building’s electricity. By looking at that number, it is clear that effort to suppress building energy consumption should be directed to air conditioning system. Recently, phase change substances, such as ice slurry, receive broad attention since the substances has ability to save energy in hydronic cooling system. Previous experiments by author showed that certain phase change material, i.e. trimethylolethane trihydrate, is able to save energy of a chiller. However, in Indonesia, the material is quite expensive. In this research, applicability of some lower-price materials, i.e. mixture of vegetables oil and biodiesel, as phase change material in secondary refrigerant were evaluated. Some thermal characteristics, such as freezing and melting temperatures, and also latent heat of the oils are explained in this paper.
GAMBARAN PRAKTIK PENCEGAHAN PENULARAN TB PARU DI KELUARGA DI WILAYAH KERJA PUSKESMAS KEDUNGWUNI I KABUPATEN PEKALONGAN Didin Mujahidin
FIKkeS Vol 8, No 2 (2015): JURNAL KEPERAWATAN
Publisher : FIKkeS

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Abstract

Penularan utama TB Paru adalah bakteri yang terdapat dalam droplet yang dikeluarkan penderita sewaktu batuk, bersin, bahkan berbicara, sehingga pada lingkungan populasi yang padat angka kejadian TB Paru menjadi tinggi. Pencegahan TB Paru dapat dilakukan oleh keluarga. Peran dari keluarga sangat penting bagi setiap aspek perawatan kesehatan. Tujuan penelitian untuk mendeskripsikan praktik pencegahan penularan TB Paru di keluarga. Penelitian ini menggunakan metode deskriptif. Sampel penelitian ini adalah kelurga yang di dalamnya terdapat penderita TB Paru di wilayah Puskesmas Kedungwuni I Kabupaten Pekalongan pada bulan Juni 2013 sebanyak 31 keluarga. Alat pengumpulan data menggunakan kuesioner dengan teknik angket. Hasil uji statistik diperoleh kesimpulan sebagian besar (64,5%) kurang dalam melakukan praktik menutup mulut pada waktu batuk dan bersin, sebagian besar (51,6%) kurang dalam melakukan praktik meludah pada tempat khusus yang sudah diberi disinfektan, sebagian besar (51,6%) telah melakukan praktik imunisasi BCG pada bayi, sebagian besar (41,9%) telah melakukan dengan baik praktik mengusahakan sinar matahari dan udara segar masuk ke dalam rumah, sebagian besar (64,5%) kurang dalam melakukan praktik menjemur bantal dan kasur terutama di pagi hari, sebagian besar (67,7%) kurang dalam melakukan praktik memisahkan barang yang digunakan penderita, sebagian besar (58,1%) kurang dalam melakukan praktik pemberian makanan yang bergizi tinggi sebagian besar (74,2%) kurang dalam melakukan praktik pengadaan ventilasi rumah. Petugas kesehatan sebaiknya memberikan penyuluhan secara berulang tentang pencegahan penularan penyakit TB Paru pada penderita TB Paru dan melibatkan anggota keluarga dalam pencegahan penularan TB Paru di dalam keluarga.Kata kunci : Praktik Pencegahan, TB Paru
Co-Authors Abdul Rajab Achmad Romadin Ade Danova Affrida Affrida Agustono Wibowo Ahmad Fauzi Ahwan Ahwan Aisyah Aisyah Aisyah Aisyah Alfhons Daniel Sirampun Aminudin Sulaeman Andi Pawawoi Andi Suhendi Anita Alni Anita Alni Anita Alni, Anita Ari D. Pasek Aryadi Suwono Asep Aripin Asnizar Asnizar Buchari Buchari Chavasiri, Warinthorn Dadan Damayandri Danova, Ade Eliza Eliza Emilia Evi Marlina Emilio L. Ghisalberti Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Fareza, Muhamad Salman Fera Kurniadewi Hans Martin Rudolf Hoffman Hans Martin Rudolf Hoffman, Hans Martin Rudolf Hermawati, Elvira Hiromitsu Takayama Hiromitsu Takayama Ilham ardatul putra Indra Noviandri Iqbal Musthapa Irfansyah Rizal Joko Santoso Kurniadewi, Fera Lia Dewi Juliawati Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Mariko Kitajima Mariko Kitajima Meilisa Dara Puspita Muhtadi Muhtadi Nila Berghuis Tamaela Nila Berghuis Tamaela, Nila Berghuis Nindita Fransiska Rahmawati Norio Aimi Norio Aimi Nuryanti Nuryanti Pirim Setiarso Pirim Setiarso Rehana Rehana Reny Rosalina Reny Rosalina Rino Rakhmata Mukti Robby Roswanda Rusjdi Tamin Rusjdi Tamin Sa'adah, Pipih Lutfi Shinta Ellisya Fauzia Siti Nurbayti Siti Zubaidah Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Soerya Dewi Marliyana Soerya Dewi Marliyana Sulaeman, Aminudin Syamsurizal Syamsurizal Tedi Abdul Ghofar Teguh Hafiz Ambarwibawa Tukiran Tukiran Valentina Adimurti Yana M Syah Yana Maolana Syah Yani F. Alli YAYA RUKAYADI Yohanes B.D. Wangge Yoharmus Syamsu Yudha Taufantri Yuli S. Indartono