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All Journal B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah
Arieta Fadia Aunillah
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Dentistry

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ANTIBACTERIAL ACTIVITY OF ANDROGRAPHOLIDE ON THE GROWTH OF PORPHYROMONAS GINGIVALIS Fauzia Nilam Orienty; Citra Lestari; Arieta Fadia Aunillah
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol. 13 No. 1 (2026): Vol 13 No 1 (Juni 2026)
Publisher : Universitas Baiturrahmah

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Abstract

Porphyromonas gingivalis is the main bacteria that causes periodontitis, and the use of antibiotics such as metronidazole can cause side effects and resistance. Andrographolide from the bitter plant is a natural alternative that has potential as an antibacterial. This study aims to evaluate the antibacterial activity of Andrographolide against P. gingivalis using the disc diffusion method at concentrations of 6 mg/mL, 8 mg/mL, and 10 mg/mL. Metronidazole 0.5 mg/mL was used as a positive control and 96% ethanol as a negative control. The results showed that Andrographolide concentrations of 6 mg/mL and 8 mg/mL produced a moderate inhibition zone, while a concentration of 10 mg/mL produced a strong inhibition zone. This study concluded that Andrographolide has antibacterial activity against P. gingivalis and shows an increase in inhibition with increasing concentration. 
Co-Authors Citra Lestari Fauzia Nilam Orienty