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All Journal Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya
Mely Purnadianty
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Diskordansi Kadar CRP dan LED pada Pasien DM Tipe-2 dengan Ulkus Kaki Diabetik Analisis dengan Pendekatan Biofisika Arshy Prodyanatasari; Mely Purnadianty; Mardiana Prasetyani Putri; Novia Agustina; Isni pra fitrilia
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 7 No 1 (2026): Juni 2026
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v7i1.360

Abstract

Discordance between C-Reactive Protein (CRP) levels and Erythrocyte Sedimentation Rate (ESR) in type-2 diabetes mellitus patients with ulcers is frequently encountered in clinical practice, yet the underlying biophysical mechanisms remain largely unexplored. This study aimed to analyze the effect of CRP levels on erythrocyte membrane zeta potential and ESR in type-2 diabetes mellitus patients with ulcers. An observational analytic study with a cross-sectional design was conducted from June to July 2025 at Daha Husada Hospital, Kediri City. The population comprised all 85 inpatients with type-2 diabetes mellitus and ulcers in 2024, with a sample of 20 patients selected through purposive sampling based on inclusion and exclusion criteria. Primary data included CRP level examination (latex agglutination method), ESR (Westergren method), and erythrocyte membrane zeta potential (zeta potential analyzer). Data were analyzed using Pearson correlation and linear regression tests with SPSS version 25 (p<0.05). The results showed that among 20 respondents, 18 patients (90%) had negative CRP (<6 mg/L) and 2 patients (10%) had positive CRP. A total of 12 patients (60%) exhibited increased ESR, of which 10 (55.6%) had negative CRP. Both patients with positive CRP showed highly significant ESR increases (75 mm/hour and 110 mm/hour). This study confirms the presence of discordance between CRP and ESR in half of the respondents, indicating the role of erythrocyte membrane zeta potential as a biophysical mediator in determining ESR. Further research with direct zeta potential measurement and molecular form analysis of CRP is essential to strengthen these findings.
Analisis Korelasi Tingkat Timbal (Pb) dan Kreatinin dalam Darah pada Kelompok Manusia Silver di Wilayah Kediri Mardiana Prasetyani Putri; Arshy Prodyanatasari M.Pd.; Mely Purnadianty; Novia Agustina; Nita Ermawati
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 7 No 1 (2026): Juni 2026
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v7i1.395

Abstract

Heavy metal exposure, such as lead (Pb), poses a severe threat to human health due to its toxic nature, which can trigger vital organ damage, particularly in the kidneys. The 'silver human' group is at high risk of Pb exposure due to the routine application of metallic paint over their entire bodies. This research aimed to evaluate the correlation between blood lead concentrations and serum creatinine levels as an indicator of kidney function among silver humans in Kediri City. This observational study, utilizing a cross-sectional design, involved six silver human subjects selected through total sampling. Pb analysis was performed using Atomic Absorption Spectrophotometry (AAS), while creatinine levels were assessed using standard laboratory methods. All respondents (100%) exhibited Pb levels within the normal range, with an average of 7.000 µg/dL. However, regarding the creatinine parameter, 50% of the respondents were found to have levels exceeding the normal threshold. Pearson statistical analysis indicated a p-value of 0.785 (p > 0.05). Consequently, no significant correlation was observed between blood lead levels and creatinine concentrations among the research subjects in Kediri City.
Co-Authors Arshy Prodyanatasari Arshy Prodyanatasari M.Pd. Ermawati, Nita Isni pra fitrilia Mardiana Prasetyani Putri Novia Agustina