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All Journal Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya
Arshy Prodyanatasari M.Pd.
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Analisis Viskositas Darah melalui Parameter Neutrophil Lymphocyte Ratio dan Activated Partial Thromboplastin Time sebagai Prediktor Gangguan Hemoreologi pada Pasien Diabetes Melitus Tipe 2 Mely Purnadianti; Arshy Prodyanatasari M.Pd.
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 7 No 1 (2026): Juni 2026
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v7i1.389

Abstract

Type 2 diabetes mellitus (T2DM) not only causes metabolic disorders but also triggers chronic inflammation and hypercoagulation that contribute to changes in the physical properties of blood. Neutrophil Lymphocyte Ratio (NLR) as an inflammatory marker and Activated Partial Thromboplastin Time (APTT) as a coagulation parameter have the potential to reflect hemorheological disturbances that can be explained through Poiseuille's law. This study aimed to analyze the correlation between NLR and APTT and interpret it from a biophysical perspective. A cross-sectional study involved 21 T2DM patients at Mojowarno Christian Hospital, Jombang. NLR examination used a Mindray BC-5380 hematology analyzer and APTT used a CoaDATA 501 coagulometer. Results showed mean NLR of 3.43 (33% increased) and APTT of 30.40 seconds (95% normal). Spearman Rank correlation test showed no significant relationship between NLR and APTT (r=0.272; p=0.234). Although not statistically correlated, biophysically both parameters independently contribute to increased blood viscosity which, according to Poiseuille's law, will decrease blood flow rate and increase the risk of vascular complications. Direct viscosity measurement is needed for empirical confirmation. This study underscores the importance of a multidisciplinary approach in understanding the pathophysiology of T2DM.
Analisis Korelasi Tingkat Timbal (Pb) dan Kreatinin dalam Darah pada Kelompok Manusia Silver di Wilayah Kediri Mardiana Prasetyani Putri; Arshy Prodyanatasari M.Pd.; Mely Purnadianty; Novia Agustina; Nita Ermawati
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 7 No 1 (2026): Juni 2026
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v7i1.395

Abstract

Heavy metal exposure, such as lead (Pb), poses a severe threat to human health due to its toxic nature, which can trigger vital organ damage, particularly in the kidneys. The 'silver human' group is at high risk of Pb exposure due to the routine application of metallic paint over their entire bodies. This research aimed to evaluate the correlation between blood lead concentrations and serum creatinine levels as an indicator of kidney function among silver humans in Kediri City. This observational study, utilizing a cross-sectional design, involved six silver human subjects selected through total sampling. Pb analysis was performed using Atomic Absorption Spectrophotometry (AAS), while creatinine levels were assessed using standard laboratory methods. All respondents (100%) exhibited Pb levels within the normal range, with an average of 7.000 µg/dL. However, regarding the creatinine parameter, 50% of the respondents were found to have levels exceeding the normal threshold. Pearson statistical analysis indicated a p-value of 0.785 (p > 0.05). Consequently, no significant correlation was observed between blood lead levels and creatinine concentrations among the research subjects in Kediri City.
Co-Authors Ermawati, Nita Mardiana Prasetyani Putri Mely Purnadianti Mely Purnadianty Novia Agustina