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All Journal Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences.
Tiwi Oktaviyani
Universitas Muhammadiyah Magelang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi Dan Optimasi Sediaan Salep Luka Akut Berbasis Daun Wungu Graptophyllum Pictum L. Griff Dan Madu Klanceng Tiwi Oktaviyani; Ratna Wijayatri; Eka Sakti Wahyuningtyas; Estrin Handayani; Sodiq Kamal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.409

Abstract

Abstract: Acute wounds require quick and appropriate treatment to prevent complications such as infection and scar tissue formation. This study aims to develop and optimize an ointment formula based on Graptophyllum pictum L. Griff wungu leaf extract and klanceng honey, which is intended to prepare for the healing of acute wounds. Graptophyllum pictum L Griff leaves are known to have anti-inflammatory and antimicrobial properties, while klanceng honey is famous for its ability to accelerate tissue regeneration. The research process included the determination of Graptophyllum pictum L Griff leaves to ensure the authenticity of the ingredients, extraction using the maceration method with 96% ethanol and the manufacture of Graptophyllum pictum L Griff leaves ointment with concentrations of F1 10%, F2 7.5% and F3 5%. Evaluation of physical properties through a series of preparation tests to assess organoleptic, homogeneity, pH, dispersibility, adhesion, and stability. The optimization of the ointment preparation of the combination of Graptophyllum pictum L Griff leaves and klanceng honey showed that the ointment met all quality criteria as an ointment preparation intended for acute wounds, the preparation also had excellent stability. This research is expected to be the basis for the development of natural products for the treatment of acute wounds that are more effective, and safe to use.
Identifikasi Senyawa Aktif dalam Daun Dadap Serep (Erythrina subumbrans (Hassk.) Merr) dan Potensinya sebagai Antioksidan Lailatul Azizah Okta Nauval; Ratna Wijayatri; Tiwi Oktaviyani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1164

Abstract

Background: Erythrina subumbrans (Hassk.) Merr, locally known as dadap serep, is a medicinal plant traditionally used to treat various ailments, suggesting the presence of bioactive compounds. Scientific exploration of its phytochemical profile and antioxidant potential, however, remains limited compared to other species in the genus. Objective: This study aimed to (1) identify the bioactive compound groups in the 70% ethanol extract of Erythrina subumbrans leaves through phytochemical screening and Thin Layer Chromatography (TLC), and (2) evaluate its antioxidant activity quantitatively using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method. Methods: The leaves were extracted via maceration using 70% ethanol. The extract was subjected to standard phytochemical screening tests for flavonoids, alkaloids, saponins, and tannins. Flavonoid profiling was performed using TLC with a quercetin standard. Antioxidant activity was assessed by the DPPH method, with vitamin C as a reference standard, and the IC₅₀ value was determined. Results: Phytochemical screening confirmed the presence of flavonoids, alkaloids, saponins, and tannins. TLC analysis indicated the presence of flavonoid compounds, with one major spot showing an Rf value similar to the quercetin standard. The DPPH assay revealed that the extract possesses strong antioxidant activity, with an IC₅₀ value of 49.94 ppm. According to established antioxidant strength criteria, this IC₅₀ value is categorized as very strong.Conclusion: The 70% ethanol extract of Erythrina subumbrans leaves contains diverse bioactive compounds, particularly flavonoids, and exhibits very strong antioxidant activity. These findings scientifically support its traditional use and highlight its potential as a promising source of natural antioxidants for further pharmaceutical or nutraceutical development.
Co-Authors Eka Sakti Wahyuningtyas Estrin Handayani Lailatul Azizah Okta Nauval Ratna Wijayatri Ratna Wijayatri Sodiq Kamal