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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Kefarmasian AKFARINDO CERATA
Ratna Wijayatri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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GAMBARAN PENANGANAN KASUS ASMA PASIEN PEDIATRI DI PUSKESMAS KOTAGEDE I YOGYAKARTA PERIODE JULI - DESEMBER 2015 Ratna Wijayatri; Anggita Tiara Ayu Wijareni
Jurnal Kefarmasian Akfarindo Vol 2 No 1 (2017)
Publisher : Akademi Farmasi Indonesia Yogyakarta

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Abstract

Asma merupakan salah satu penyakit saluran napas yang banyak diderita oleh anak-anak. Di Indonesia, sekitar 6,5% anak usia <14 tahun menderita asma. Tujuan dari penelitian ini adalah untuk mengetahui kesesuaian pengobatan asma pada pasien pediatri di Puskesmas Kotagede I Yogyakarta periode Juli - Desember 2015 yang meliputi diagnosis, nama obat, golongan obat, dibandingkan dengan Pedoman Pengendalian Penyakit Asma Departemen Kesehatan RI tahun 2009 serta kesesuaian dosis obat dibandingkan dengan Drug Information Handbook. Penelitian yang dilakukan bersifat deskriptif non analitik pada pasien asma pediatri di Puskesmas Kotagede I Yogyakarta Periode Juli – Desember 2015. Pengambilan data melalui pendekatan secara retrospektif dengan melihat data lampau berdasarkan data rekam medis meliputi jenis kelamin, usia, golongan dan jenis obat, berat badan, dan dosis. Hasil evaluasi penggunaan obat asma pada pasien pediatri diolah menjadi bentuk presentase kesesuaian pengobatan dan dosis pengobatan asma dan disajikan dalam bentuk tabel. Hasil penelitian pada pasien asma pediatri di Puskesmas Kotagede I Yogyakarta Periode Juli- Desember 2015 menunjukkan bahwa pola penggunaan obat asma sudah sesuai dengan Pedoman Pengendalian Penyakit Asma Departemen Kesehatan RI tahun 2009. Kesesuaian dosis dibandingkan dengan Drug Information Handbook belum sepenuhnya sesuai, masih ditemukan dosis yang tidak sesuai. Kesesuaian dosis sebanyak 60% dan ketidaksesuaian dosis sebanyak 40%.
Wound healing activity of aloe vera extract spray on acute wound in male balb/c mice Isabella Meliawati Sikumbang; Ratih Arum Astuti; Eka Sakti Wahyuningtyas; Heni Lutfiyati; Ratna Wijayatri; Nasruddin Nasruddin
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2540.844 KB) | DOI: 10.12928/pharmaciana.v10i3.16640

Abstract

Acute wounds are tissue injuries that are at risk of infection so they require good treatment and care. Aloe vera (Aloe vera L) contains glukomanan compound that are thought to be beneficial in the wound healing process. Spray preparations in the treatment of wounds can provide concentrared content, dry quickly, and easy to use. The purpose of this study was to examine the spray activity of Aloe extract as an acute wound healer in male balb/c mice. This research method is experimental research. The steps that have been carried out include maceration extraction from Aloe vera simplicia powder with 70% ethanol which is then thick extracted in freeze drying to powder extract. Aloe vera spray preparations are made with concentrations of 1%, 3% and 5%. Balb / C mice that had made full thickness acute wounds were divided into 5 treatment groups namely positive control (PC), negative control (NC), F1, F2, and F3. Mice were treated for 14 days then the wound ratio was calculated and analyzed with one way anova test followed by post hoc tukey cramer test. The results showed that the higher of the percentage of Aloe vera extract is the higher of the wound healing activity. 
Penentuan Kurva Pertumbuhan dan Aktivitas Antibakteri dari Isolat Ekstrak Etil Asetat Bakteri (Te.325) terhadap Staphylococcus aureus dan Escherichia coli Alfian Syarifuddin; Ratna Wijayatri; Ichsan Feri Kurniawan; Herma Fanani Agusta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1079

Abstract

The development of infection cases and inappropriate use of antibiotics has led to cases of antibiotic resistance. An alternative to overcoming the many antibiotics that are already resistant to bacteria has led to the discovery of new antibiotics. One of the processes of discovering antibiotics is from microorganisms, namely bacteria. The exploration process for the discovery of antibiotics uses a bacterial growth phase approach, namely the stationary phase which produces secondary metabolites, one of, which are bacteria that contain antibiotic compounds. Te.325 isolate is a producer of bacterial antibiotics but The growth phase is not yet known and can be used to approach the process of obtaining antibiotics. The study was to obtain the growth phase time of the Te.325 isolate and to extract antibiotic compounds from the isolate. The determination of the growth curve is based on the weight of cell biomass and the absorbance value on UV/ Vis spectrophotometry of the culture sampled every day for 14 days of culture incubation. The results showed a log/exponential phase on 5th day and a stationary phase on 9th day. The activity test of the ethyl acetate extract was carried out using the well method with an extract concentration of 40%, which resulted in an average diameter of 8.04mm in Staphylococcus aureus and 9.035mm in Escherichia coli. The ethyl acetate extract of Te.325 has medium potency.
A Case Study: Application of Kersen Leaf Extract (Muntingia Calabura L.) and Manuka Honey Ointment Combination On Second Degree Superficial Burns Shella Oktavia Cahyaningrum; Estrin Handayani; Eka Sakti Wahyuningtyas; Ratna Wijayatri
Viva Medika Vol 17 No 1 (2024)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i1.1302

Abstract

Background: Burns are a significant cause of morbidity and mortality globally. Intensive treatment is necessary to prevent infection and manage erythema in burn wounds. This case study aims to evaluate the effectiveness of a combination ointment containing Kersen (Muntingia calabura L.) leaf extract and Manuka honey in treating second degree superficial burns. Methods: A case study design employing evidence-based practice was used. Data were collected through interviews, observations, and physical examination. The study was conducted from October 14-28, 2023 in Mirikerep Hamlet, Pringsurat Village, Temanggung Regency, Indonesia. A comprehensive nursing care approach was implemented, including assessment, diagnosis, intervention, implementation, and evaluation. Results: Macroscopic examination revealed a significant reduction in wound area from 5.5x3 cm to 0.5x0.3 cm after treatment with the combination ointment. The ointment effectively promoted epithelialization and tissue regeneration in the healing process of second-degree superficial burns. Conclusions: The combination ointment containing Kersen leaf extract and Manuka honey demonstrates potential as an effective treatment for second degree superficial burns. Further research is warranted to elucidate the mechanisms underlying its therapeutic effects.
Standarisasi Parameter Spesifik Non Spesifik Ekstrak Etanol Daun Kersen (Muntingia calabura L) Asal Daerah Blitar Jawa Timur Jihan Arini; Ratna Wijayatri; Eka Sakti Wahyuningtyas; Estrin Handayani; Herma Fanani Agusta
CERATA Jurnal Ilmu Farmasi Vol 16 No 2 (2025): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v16i2.1642

Abstract

Muntingia calabura L, atau yang biasa disebut kersen banyak ditemukan di wilayah beriklim tropis Indonesia seperti daerah Blitar Jawa Timur. Tanaman kersen (Muntingia calabura L) banyak ditemukan pada wilayah beriklim tropis, serta temasuk dalam jenis tanaman perennial yang mampu tumbuh tinggi hingga 10 meter, dengan batang tegak yang berbentuk bulat, berkayu, dan memiliki sistem percabangan sympodial. Standarisasi tanaman kersen (Muntingia calabura L) memiliki tujuan sebagai upaya memperoleh produk herbal yang terjamin keamanan, khasiat, dan mutunya. Ekstrak tanaman ini distandarisasi berdasarkan dua parameter, yaitu parameter spesifik dan parameter non-spesifik. Parameter spesifik, tanaman yang digunakan adalah (Muntingia calabura L), dengan bagian yang dimanfaatkan yaitu daun (folium). Hasil uji organoleptik memperlihatkan bahwa ekstrak yang diperoleh memiliki konsistensi yang kental berwarna hijau tua kehitam-hitaman, beraroma khas pahit, serta memiliki rasa pahit. Pengujian kandungan kimia mengungkap bahwa ekstrak etanol daun kersen (Muntingia calabura L) memiliki kandungan alkaloid, flavonoid, saponin, tannin, dan terpenoid. Pada parameter non-spesifik, hasil uji kadar air menunjukkan bahwa ekstrak etanol daun kersen (Muntingia calabura L) memiliki kadar air 0%, dengan bobot jenis sebesar 1,0443 g/ml. Selain itu, hasil analisis juga menunjukkan bahwa ekstrak ini bebas dari cemaran logam berat, baik kadmium (Cd) maupun timbal (Pb).
Co-Authors Alfian Syarifuddin Anggita Tiara Ayu Wijareni Astuti, Ratih Arum Eka Sakti Wahyuningtyas Estrin Handayani Heni Lutfiyati Herma Fanani Agusta Ichsan Feri Kurniawan Isabella Meliawati Sikumbang Jihan Arini Nasruddin Nasruddin Shella Oktavia Cahyaningrum