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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Farmasi Indonesia
Ratna Wijayatri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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GAMBARAN PENANGANAN KASUS ASMA PASIEN PEDIATRI DI PUSKESMAS KOTAGEDE I YOGYAKARTA PERIODE JULI - DESEMBER 2015 Ratna Wijayatri; Anggita Tiara Ayu Wijareni
Jurnal Kefarmasian Akfarindo Vol 2 No 1 (2017)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Asma merupakan salah satu penyakit saluran napas yang banyak diderita oleh anak-anak. Di Indonesia, sekitar 6,5% anak usia <14 tahun menderita asma. Tujuan dari penelitian ini adalah untuk mengetahui kesesuaian pengobatan asma pada pasien pediatri di Puskesmas Kotagede I Yogyakarta periode Juli - Desember 2015 yang meliputi diagnosis, nama obat, golongan obat, dibandingkan dengan Pedoman Pengendalian Penyakit Asma Departemen Kesehatan RI tahun 2009 serta kesesuaian dosis obat dibandingkan dengan Drug Information Handbook. Penelitian yang dilakukan bersifat deskriptif non analitik pada pasien asma pediatri di Puskesmas Kotagede I Yogyakarta Periode Juli – Desember 2015. Pengambilan data melalui pendekatan secara retrospektif dengan melihat data lampau berdasarkan data rekam medis meliputi jenis kelamin, usia, golongan dan jenis obat, berat badan, dan dosis. Hasil evaluasi penggunaan obat asma pada pasien pediatri diolah menjadi bentuk presentase kesesuaian pengobatan dan dosis pengobatan asma dan disajikan dalam bentuk tabel. Hasil penelitian pada pasien asma pediatri di Puskesmas Kotagede I Yogyakarta Periode Juli- Desember 2015 menunjukkan bahwa pola penggunaan obat asma sudah sesuai dengan Pedoman Pengendalian Penyakit Asma Departemen Kesehatan RI tahun 2009. Kesesuaian dosis dibandingkan dengan Drug Information Handbook belum sepenuhnya sesuai, masih ditemukan dosis yang tidak sesuai. Kesesuaian dosis sebanyak 60% dan ketidaksesuaian dosis sebanyak 40%.
Wound healing activity of aloe vera extract spray on acute wound in male balb/c mice Isabella Meliawati Sikumbang; Ratih Arum Astuti; Eka Sakti Wahyuningtyas; Heni Lutfiyati; Ratna Wijayatri; Nasruddin Nasruddin
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2540.844 KB) | DOI: 10.12928/pharmaciana.v10i3.16640

Abstract

Acute wounds are tissue injuries that are at risk of infection so they require good treatment and care. Aloe vera (Aloe vera L) contains glukomanan compound that are thought to be beneficial in the wound healing process. Spray preparations in the treatment of wounds can provide concentrared content, dry quickly, and easy to use. The purpose of this study was to examine the spray activity of Aloe extract as an acute wound healer in male balb/c mice. This research method is experimental research. The steps that have been carried out include maceration extraction from Aloe vera simplicia powder with 70% ethanol which is then thick extracted in freeze drying to powder extract. Aloe vera spray preparations are made with concentrations of 1%, 3% and 5%. Balb / C mice that had made full thickness acute wounds were divided into 5 treatment groups namely positive control (PC), negative control (NC), F1, F2, and F3. Mice were treated for 14 days then the wound ratio was calculated and analyzed with one way anova test followed by post hoc tukey cramer test. The results showed that the higher of the percentage of Aloe vera extract is the higher of the wound healing activity. 
Penentuan Kurva Pertumbuhan dan Aktivitas Antibakteri dari Isolat Ekstrak Etil Asetat Bakteri (Te.325) terhadap Staphylococcus aureus dan Escherichia coli Alfian Syarifuddin; Ratna Wijayatri; Ichsan Feri Kurniawan; Herma Fanani Agusta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1079

Abstract

The development of infection cases and inappropriate use of antibiotics has led to cases of antibiotic resistance. An alternative to overcoming the many antibiotics that are already resistant to bacteria has led to the discovery of new antibiotics. One of the processes of discovering antibiotics is from microorganisms, namely bacteria. The exploration process for the discovery of antibiotics uses a bacterial growth phase approach, namely the stationary phase which produces secondary metabolites, one of, which are bacteria that contain antibiotic compounds. Te.325 isolate is a producer of bacterial antibiotics but The growth phase is not yet known and can be used to approach the process of obtaining antibiotics. The study was to obtain the growth phase time of the Te.325 isolate and to extract antibiotic compounds from the isolate. The determination of the growth curve is based on the weight of cell biomass and the absorbance value on UV/ Vis spectrophotometry of the culture sampled every day for 14 days of culture incubation. The results showed a log/exponential phase on 5th day and a stationary phase on 9th day. The activity test of the ethyl acetate extract was carried out using the well method with an extract concentration of 40%, which resulted in an average diameter of 8.04mm in Staphylococcus aureus and 9.035mm in Escherichia coli. The ethyl acetate extract of Te.325 has medium potency.
GAMBARAN PENANGANAN KASUS ASMA PASIEN PEDIATRI DI PUSKESMAS KOTAGEDE I YOGYAKARTA PERIODE JULI - DESEMBER 2015 Ratna Wijayatri; Anggita Tiara Ayu Wijareni
Jurnal Kefarmasian Akfarindo Vol 2 No 1 (2017)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v0i0.14

Abstract

Asma merupakan salah satu penyakit saluran napas yang banyak diderita oleh anak-anak. Di Indonesia, sekitar 6,5% anak usia <14 tahun menderita asma. Tujuan dari penelitian ini adalah untuk mengetahui kesesuaian pengobatan asma pada pasien pediatri di Puskesmas Kotagede I Yogyakarta periode Juli - Desember 2015 yang meliputi diagnosis, nama obat, golongan obat, dibandingkan dengan Pedoman Pengendalian Penyakit Asma Departemen Kesehatan RI tahun 2009 serta kesesuaian dosis obat dibandingkan dengan Drug Information Handbook. Penelitian yang dilakukan bersifat deskriptif non analitik pada pasien asma pediatri di Puskesmas Kotagede I Yogyakarta Periode Juli – Desember 2015. Pengambilan data melalui pendekatan secara retrospektif dengan melihat data lampau berdasarkan data rekam medis meliputi jenis kelamin, usia, golongan dan jenis obat, berat badan, dan dosis. Hasil evaluasi penggunaan obat asma pada pasien pediatri diolah menjadi bentuk presentase kesesuaian pengobatan dan dosis pengobatan asma dan disajikan dalam bentuk tabel. Hasil penelitian pada pasien asma pediatri di Puskesmas Kotagede I Yogyakarta Periode Juli- Desember 2015 menunjukkan bahwa pola penggunaan obat asma sudah sesuai dengan Pedoman Pengendalian Penyakit Asma Departemen Kesehatan RI tahun 2009. Kesesuaian dosis dibandingkan dengan Drug Information Handbook belum sepenuhnya sesuai, masih ditemukan dosis yang tidak sesuai. Kesesuaian dosis sebanyak 60% dan ketidaksesuaian dosis sebanyak 40%.
Formulasi Dan Optimasi Sediaan Salep Luka Akut Berbasis Daun Wungu Graptophyllum Pictum L. Griff Dan Madu Klanceng Tiwi Oktaviyani; Ratna Wijayatri; Eka Sakti Wahyuningtyas; Estrin Handayani; Sodiq Kamal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.409

Abstract

Abstract: Acute wounds require quick and appropriate treatment to prevent complications such as infection and scar tissue formation. This study aims to develop and optimize an ointment formula based on Graptophyllum pictum L. Griff wungu leaf extract and klanceng honey, which is intended to prepare for the healing of acute wounds. Graptophyllum pictum L Griff leaves are known to have anti-inflammatory and antimicrobial properties, while klanceng honey is famous for its ability to accelerate tissue regeneration. The research process included the determination of Graptophyllum pictum L Griff leaves to ensure the authenticity of the ingredients, extraction using the maceration method with 96% ethanol and the manufacture of Graptophyllum pictum L Griff leaves ointment with concentrations of F1 10%, F2 7.5% and F3 5%. Evaluation of physical properties through a series of preparation tests to assess organoleptic, homogeneity, pH, dispersibility, adhesion, and stability. The optimization of the ointment preparation of the combination of Graptophyllum pictum L Griff leaves and klanceng honey showed that the ointment met all quality criteria as an ointment preparation intended for acute wounds, the preparation also had excellent stability. This research is expected to be the basis for the development of natural products for the treatment of acute wounds that are more effective, and safe to use.
Co-Authors Alfian Syarifuddin Anggita Tiara Ayu Wijareni Astuti, Ratih Arum Eka Sakti Wahyuningtyas Estrin Handayani Heni Lutfiyati Herma Fanani Agusta Ichsan Feri Kurniawan Isabella Meliawati Sikumbang Nasruddin Nasruddin Sodiq Kamal Tiwi Oktaviyani