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Roostantia Indrawati
Universitas Hang Tuah
Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice

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Effect of Ethanol Extract of Sea Pandan Fruit (Pandanus Tectorius) on Blood Glucose Levels in Male White Rats (Rattus Norvegicus) Induced by Dexamethasone Ghifara Kireina Annisa; Nita Pranitasari; R. Varidianto Yudo Tjahjono; Roostantia Indrawati
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1214

Abstract

Diabetes mellitus is a metabolic disorder with increased blood glucose due to decreased insulin production or sensitivity. Chronic hyperglycemia can lead to endothelial dysfunction and vascular complications. Dexamethasone as a synthetic glucocorticoid can cause hyperglycemia through increased gluconeogenesis and insulin resistance. The antioxidant content in sea pandanus (Pandanus tectorius) has the potential to lower blood glucose levels. This study aims to determine the effect of ethanol extract of sea pandan fruit on blood glucose levels of male white rats (Rattus norvegicus) induced by dexamethasone. This study aims to determine the effect of ethanol extract of sea pandan fruit (Pandanus tectorius) on blood glucose levels in male white rats (Rattus norvegicus) induced by dexamethasone. Experimental research with a post test only control group on 30 mice grouped into 3 groups. Namely, K(-) which was only given standard feed, K(+) which was induced by dexamethasone at a dose of 5 mg/KgBB, and KP which was induced by dexamethasone at a dose of 5 mg/KgBB and given Pandanus tectorius fruit extract at a dose of 100 mg/KgBB, then at the end of the study a blood sample was taken to measure blood glucose levels and then terminated. The sample was selected using simple random sampling technique. The data was analyzed using the One Way Anova test. In the results of the study, the average blood glucose level K(-) = 170.37 was obtained; K(+) = 274.62; KP = 243. In the One Way Anova parametric test, a significant result was obtained which was 0.005 (p<0.05). Then in the Post Hoc Games-Howell test, K(-) and K(+) had a significance of 0.001 (p<0.05), while the K(-) and KP groups as well as K(+) and KP showed no significant results. This suggests that ethanol extract of Pandanus tectorius fruit did not successfully inhibit the increase in blood glucose levels in dexamethasone-induced white rats. The administration of ethanol extract of Pandanus tectorius fruit as a therapy was able to reduce the blood glucose level of male Rattus norvegicus induced by dexamethasone compared to a K(+) positive control of 31.62 mg/dL (11.5%).
Effectiveness of Ethanol Extract From Sea Pandan (Pandanus Tectorius) on Hydroxyproline Levels as A Parameter For Collagen Formation in The Healing Process of Incision Wounds in Male Rattus Norvegicus Vanessa Hedyana Putri; Roostantia Indrawati; Andi Abdullah; Afifah Sekarkusuma; Shehnaz Neisa Rasyid
Asian Journal of Social and Humanities Vol. 4 No. 4 (2026): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v4i4.674

Abstract

This study aims to determine the effectiveness of ethanol extract gel of sea pandan fruit on hydroxycroline levels as a parameter for collagen formation in the healing process of incisional wounds of male white rats (Rattus norvegicus). This study is a laboratory experimental research with a post-test only control group design. The experimental animals used were male white rats which were divided into negative control groups (Gel Base), positive control (Bioplacenton®), and treatment groups with marine pandan ethanol extract gel concentrations of 10%, 20%, and 30%. The treatment was carried out for 10 days at the Integrated Biomolecular and Hyperbaric Laboratory, Faculty of Medicine, Hang Tuah University, Surabaya. The measured parameter was the level of hydroxychlorine of skin tissue. The results showed that there was a significant difference in hydroxyproline levels between treatment groups (p=0.032). The 20% concentration provides the most optimal effect with the highest average hydroxycroline levels and the narrowest data distribution, signaling more consistent fibroblast stimulation and collagen deposition. A concentration of 10% indicates high variability so the effect is less stable, while a concentration of 30% provides a moderate effect that may be affected by mild irritation. The conclusion of this study is that sea pandan fruit ethanol extract gel has the potential to accelerate the healing of incision wounds through increasing hydroxycrolin levels as an indicator of collagen formation.
Co-Authors Afifah Sekarkusuma Andi Abdullah Ghifara Kireina Annisa Nita Pranitasari R. Varidianto Yudo Tjahjono Shehnaz Neisa Rasyid Vanessa Hedyana Putri