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All Journal Medical and Health Science Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Indonesian Journal of Global Health Research
Nita Pranitasari
Universitas Hang Tuah
Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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The Effect of Caulerpa Cylindracea Extract on Histopathology Depiction of Male Rattus Norvegicus Gaster Mucosa Induced by Indomethacin FITRI HANDAJANI; Adya Hidayatullah; Nita Pranitasari
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 1 (2021): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i1.1671

Abstract

ABSTRACT Background: A lot of food can repair gastric mucosal damage. For example, sea grapes or the Caulerpa cylindracea with its flavonoid content. Anti-inflammatory and anti-ulcer effect can reduce gastric lesions due to ulcerogenic agents. Indomethacin is used to induce gastric ulcers in experimental animals. Based on this background, this study was conducted to analyze the effect of Caulerpa cylindracea extract, on the histopathological picture of gastric mucosal damage of Rattus norvegicus male rats.   Method: 32 male Rattus norvegicus rats were divided into 4 groups, (1) Group K(-), the untreated group, (2) Group K(+) induced by indomethacin 30mg/kgBB per head (3) Group P1 induced by indomethacin 30 mg/kgBB and Caulerpa cylindracea extract 1gr/100grBB per head, (4) Group P2, induced by indometacin 30mg/kgBB and 2gr/100grBB of Caulerpa cylindracea extract per head.   Result: There was a significant difference (p = 0.001) between the degree of gastric mucosal damage in group K(+) given only indomethacin and group P1 given Indomethacin and 1gr/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.001) between group K(+) and group P2 that given Indomethacin and 2g/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.004) between group P1 and group P2. Data revealed on group K(-) without any treatment did not obtain significant results (p = 0.060) with group P2.    Conclusion: Giving Caulerpa cylindracea extract with 1 gr/100grBB dose and 2gr/100grBB dose can repair mucosal damage in Rattus norvegicus male rats induced by indomethacin.   
Hubungan Perilaku Merokok dengan Angka Kejadian Tuberkulosis Paru di Puskesmas Kenjeran Surabaya Auliadina Tetrania Darmastuti; Judya Sukmana; Nita Pranitasari
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 1 No. 2 (2020): Oktober
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.151 KB) | DOI: 10.37148/comphijournal.v1i2.9

Abstract

Introduction: Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis and has infected one-third of all human populations around the world, so it has been a global problem. Smoking is one of the risk factors that cause a high mortality rate in TB sufferers. Aim of study: This study aims to evaluate the relationship between smoking behaviur and the incidence of Pulmonary TB in the Kenjeran’s Primary Health Center 2017-2018. Method: This study is observative analytic research with a cross-sectional design. The population in this study were Pulmonary TB in the medical record of the Kenjeran Health Center in 2017-2018. The sample was taken based on the purposive sampling method. 71 people were suffered from pulmonary TB obtained as samples. Results and Discussions: The results of the statistical analytic stated that there was no significant correlation between smoking and the incidence of pulmonary TB, the p-value was 0,601 found in the data analysis (p > 0,05). From 71 respondents, 56 respondents (80,3%) were BTA + patients and 15 respondents (19,7%) were BTA - patients. Based on smoking behavior, there were 56 respondents (78,9%) non-smokers. Based on most sexes, 50 respondents were male. Based on the age group, most of them were in the 17-35 years, amounting to 44 respondents (62%). Conclusions: The conclusion of this research is that there is no relationship between smoking behavior and the incidence of pulmonary TB in the Kenjeran Primary Health Center in 2017-2018.
Effect of Ethanol Extract of Sea Pandan Fruit (Pandanus Tectorius) on Blood Glucose Levels in Male White Rats (Rattus Norvegicus) Induced by Dexamethasone Ghifara Kireina Annisa; Nita Pranitasari; R. Varidianto Yudo Tjahjono; Roostantia Indrawati
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1214

Abstract

Diabetes mellitus is a metabolic disorder with increased blood glucose due to decreased insulin production or sensitivity. Chronic hyperglycemia can lead to endothelial dysfunction and vascular complications. Dexamethasone as a synthetic glucocorticoid can cause hyperglycemia through increased gluconeogenesis and insulin resistance. The antioxidant content in sea pandanus (Pandanus tectorius) has the potential to lower blood glucose levels. This study aims to determine the effect of ethanol extract of sea pandan fruit on blood glucose levels of male white rats (Rattus norvegicus) induced by dexamethasone. This study aims to determine the effect of ethanol extract of sea pandan fruit (Pandanus tectorius) on blood glucose levels in male white rats (Rattus norvegicus) induced by dexamethasone. Experimental research with a post test only control group on 30 mice grouped into 3 groups. Namely, K(-) which was only given standard feed, K(+) which was induced by dexamethasone at a dose of 5 mg/KgBB, and KP which was induced by dexamethasone at a dose of 5 mg/KgBB and given Pandanus tectorius fruit extract at a dose of 100 mg/KgBB, then at the end of the study a blood sample was taken to measure blood glucose levels and then terminated. The sample was selected using simple random sampling technique. The data was analyzed using the One Way Anova test. In the results of the study, the average blood glucose level K(-) = 170.37 was obtained; K(+) = 274.62; KP = 243. In the One Way Anova parametric test, a significant result was obtained which was 0.005 (p<0.05). Then in the Post Hoc Games-Howell test, K(-) and K(+) had a significance of 0.001 (p<0.05), while the K(-) and KP groups as well as K(+) and KP showed no significant results. This suggests that ethanol extract of Pandanus tectorius fruit did not successfully inhibit the increase in blood glucose levels in dexamethasone-induced white rats. The administration of ethanol extract of Pandanus tectorius fruit as a therapy was able to reduce the blood glucose level of male Rattus norvegicus induced by dexamethasone compared to a K(+) positive control of 31.62 mg/dL (11.5%).
Co-Authors Adya Hidayatullah Auliadina Tetrania Darmastuti Ghifara Kireina Annisa HANDAJANI, FITRI Judya Sukmana R. Varidianto Yudo Tjahjono Roostantia Indrawati