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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Camellia
Evy Dharmayati
Universitas Borneo Lestari
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Knowledge and Antibiotic Adherence in Acute Respiratory Infection Patients at Karang Intan 1 Clinic Safrina Aprianti; Helmina Wati; Evy Dharmayati
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 4 No 2 (2025): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v4i2.29482

Abstract

Acute Respiratory Infection (ARI) is a bacterial infection affecting the respiratory tract, from the nasal cavity to the lungs, and contributes to nearly 4 million deaths globally each year. Knowledge refers to the information acquired and retained by individuals, while compliance indicates the extent to which patients adhere to medication instructions provided by healthcare professionals. This study aimed to assess the level of knowledge regarding antibiotics and patients’ compliance with antibiotic use. A prospective observational quantitative approach was employed from January to April 2025 at the Karang Intan 1 Health Center. The study used a cross-sectional design and included 80 ARI patients selected through total sampling. Data were collected using structured questionnaires over a two-month period. Results showed that the most frequently used antibiotic was cefadroxil, a first-generation cephalosporin, used by 52 respondents (65%). The knowledge assessment revealed that 76 respondents (95%) had good knowledge, while 4 respondents (5%) had poor knowledge. In terms of compliance, 65 respondents (81.25%) were compliant, 10 respondents (12.5%) were fairly compliant, and 5 respondents (6.25%) were less compliant. Statistical analysis using the Chi-square test demonstrated a significant relationship between knowledge level and antibiotic compliance (p < 0.000). This indicates that higher knowledge levels are associated with better compliance in antibiotic use among ARI patients at Karang Intan 1 Health Center
Inhibitor HMG-CoA Reductase dan Cholesterol-7 Alpha-Hydroxylase dari Senyawa Aktif Genus Alphitonia : Studi In Silico Hafiz Ramadhan; Didik Rio Pambudi; Jamiatul Annisa Yulida; Evy Dharmayati
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.35206

Abstract

Kolesterol merupakan gangguan metabolisme lipid yang ditandai dengan adanya peningkatan fraksi lipid dalam plasma karena aktivitas enzim 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase dan Cholesterol-7 alpha-hydroxylase (CYP7A1). Alternatif pengobatan antikolesterol dengan memanfaatkan senyawa metabolit sekunder dari genus Alphitonia. Tujuan penelitian ini untuk mengetahui potensi dan interaksi dari senyawa genus Alphitonia sebagai kandidat inhibitor HMG-CoA reductase dan cholesterol-7 alpha-hydroxylase dibandingkan dengan native ligand dan obat antikolesterol sebagai perbandingan secara in silico. Metode yang digunakan yaitu metode eksperimental eksploratif dengan uji in silico 30 senyawa marker dari genus Alphitonia terhadap  protein terget 1HW9 dan 3SN5 menggunakan aplikasi molecular docking PLANTs. Senyawa yang memiliki potensi sebagai antikolesterol karena memiliki skor docking lebih rendah dari native ligand dan obat pembanding (simvastatin dan atorvastatin) terhadap protein target 1HW9 yaitu senyawa 3-O-[β-D-Glucopyranosyl-(1→2)]-α-L-rhamnopyranosyl-quercetin  dan 6’-Heptadecanoyl-3-O-β-D- glucopyranosylsitosterol. Sedangkan terhadap protein target 3SN5 yaitu senyawa Isorhamnetin 3-O-rutinoside, Rutin, Kaempferol- 3-rutinoside, 6’-Heptadecanoyl-3-O-β-D- glucopyranosylsitosterol dan Quercetin 3-O-α-L-arabinopyranasyl(1→2)-α-L-rhamnopyranoside. Senyawa native ligand dan senyawa potensial Isorhamnetin 3-O-rutinoside dan 6’-Heptadecanoyl-3-O-β-D- glucopyranosylsitosterol memiliki residu asam amino yang hampir sama dengan native ligand. Kesimpulan dari penelitian ini kandidat terbaik yang memiliki potensi sebagai antikolesterol adalah senyawa  6’-Heptadecanoyl-3-O-β-D- glucopyranosylsitosterol
Co-Authors Didik Rio Pambudi Hafiz Ramadhan Helmina Wati Jamiatul Annisa Yulida Safrina Aprianti