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All Journal Jurnal Biologi Tropis Journal of Biodiversity and Biotechnology
Aslikh Lana Dina
Universitas Siliwangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Natural Compounds in Moringa oleifera Leaves Targeting Estrogen Receptor Beta (ESR2) for PCOS treatment: Insight from In Silico Docking Aslikh Lana Dina; Alin Robiah Al Adawiah; Ade Hilman Juhaeni
Journal of Biodiversity and Biotechnology Vol 6, No 1 (2026)
Publisher : Pusat Penelitian dan Pengembangan Bioteknologi dan Biodiversitas (P3BB) LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jbb.v6i1.115073

Abstract

Polycystic ovary syndrome (PCOS) is a health complication that often leads to infertility in women. PCOS, as a reproductive-metabolic disorder, is also related to breast cancer and other diseases. Nevertheless, there is no universal drug for PCOS treatment. Hence, exploring a new candidate’s drugs is crucial. Estrogen receptor beta (ESR2) has become a significant marker for PCOS and has the potential to be used as a target for PCOS treatment. This study aims to explore the potential use of moringa as a nutraceutical. This study provides in silico data of selected compounds (naringenin, gallic acid, quinic acid, quercetin, apigenin, and kaempferol) in moringa leaves as a candidate drug for PCOS treatment targeting ESR2. Naringenin and apigenin showed a noteworthy calculated binding affinity score from docking into ESR2 (<- 7kcal/mol). Protein-protein analysis and gene analysis showed that ESR2 is expressed in varying tissues. It strengthens the potential use of moringa as a nutraceutical. This study showed that Moringa leaves have the potential to be used as a complement to PCOS treatment.
Effective Microorganisms Improve Nutrient Use Efficiency, Growth, and Yield of Inthanon Melon under Drip Hydroponic Ade Hilman Juhaeni; Yanto Yulianto; Leny Yuliyani; Alin Robiah Al Adawiah; Aslikh Lana Dina; Yudhi Arie Priyanto; Ikhsan Rafli Muharam
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.10756

Abstract

Hydroponic cultivation of melon (Cucumis melo L.) Inthanon variety is a high-income potential product, especially in Tasikmalaya. Hydroponic offers an alternative modern agriculture that has high potential in land and water use efficiency. However, this system still faces challenges in nutrient use efficiency (NU) as well as the stability of plant growth and yield. This study aims to examine the effect of Effective Microorganisms (EM) application on nutrient use efficiency, growth, and yield of Inthanon melon in the hydroponic system. The study used a Completely Randomized Design (CRD) method with 5 EM dose treatments (0, 150, 300, 450, and 600 ml/plant) and 5 replications. EM application was carried out by pouring it onto the growing medium/polybags according to the treatment dosage. Parameters observed included nutrient use efficiency, vegetative growth, and harvest yield. Based on the results, EM did not significantly affect the vegetative growth but rather affect generative growth, especially fruit weight in dose 450 ml/plant (P4). These results showed that EM can increase the yield of Inthanon melon variety.
Co-Authors Ade Hilman Juhaeni Alin Robiah Al Adawiah Ikhsan Rafli Muharam Leny Yuliyani Yanto Yulianto Yudhi Arie Priyanto