Neonatal asphyxia is one of the leading causes of neonatal mortality worldwide, including in Indonesia. Based on WHO data in 2023, asphyxia accounted for approximately 23% of all global neonatal deaths. This study aimed to identify factors associated with the incidence of neonatal asphyxia at the Sukadana General Hospital, East Lampung, including maternal age, maternal body weight, parity, gestational age, history of delivery, and birth weight. This research employed a quantitative method with a cross-sectional design. The research population consisted of all infants born at Sukadana General Hospital during 2024, totaling 220 infants, all of whom were included as samples using a total sampling technique. Data were collected from medical records and analyzed using the Chi-Square (χ²) test to determine the correlation between independent and dependent variables. The results showed significant correlation between maternal body weight (p = 0.001), gestational age (p = 0.001), history of delivery (p = 0.001), and birth weight (p = 0.001) with the genesis of neonatal asphyxia. Infants with low birth weight, preterm gestational age, mothers with abnormal body weight, and a history of complicated delivery had a higher risk of experiencing asphyxia. In contrast, maternal age (p = 0.198) and parity (p = 0.171) did not show a significant correlation with the genesis of neonatal asphyxia. It is expected that healthcare workers can improve the quality of antenatal care (ANC), conduct early screening of risk factors, and strengthen neonatal resuscitation skills to reduce the incidence of neonatal asphyxia.