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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS
Danang Prasetyaning Amukti
Universitas Alma Ata
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Analisis Hubungan Kepatuhan Suplementasi Tablet Besi Dengan Karakteristik Ibu Melahirkan Bayi Berat Badan Lahir Rendah di RSUD Wonosari Yogyakarta Tetie Herlina; Wiwi Kustio Prillia; Danang Prasetyaning Amukti; Ifa Aris Suminingtyas; Nurul Kusumawardani
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.34945

Abstract

Low birth weight (LBW) is a leading cause of neonatal mortality, especially in developing countries. Previous studies have not comprehensively assessed the role of maternal adherence to iron tablet consumption, gestational age, maternal age, and anemia status. This study aims to analyze the relationship between adherence to iron tablet consumption and the characteristics of mothers who gave birth LBW at Wonosari Regional Hospital, Yogyakarta. This is a retrospective analytical study with a cross-sectional design on 47 pregnant women who gave birth  LBW between October 2024 and March 2025. Data collection involved the use of an adherence questionnaire to assess adherence to iron supplementation, as well as secondary data obtained from patient medical records. Statistical analysis was performed using the chi-square test to determine the relationship between variables. The results showed no statistically significant association between adherence to iron supplementation (p=0.74), maternal age (p=0.34), or anemia status (p=0.36) with LBW. However, there was a strong and statistically significant association between gestational age and LBW (p < 0.001), which showed that preterm birth is a major risk factor for LBW. In conclusion, gestational age was significantly associated with LBW, while adherence to iron supplementation, maternal age, and anemia status were not. Preventing preterm birth should be a primary focus in strategies aimed at reducing the incidence of LBW.
KRT23 SEBAGAI BIOMARKER PROGNOSTIK PADA ADENOKARSINOMA REKTAL: ANALISIS BIOINFORMATIKA BERBASIS UALCAN: KRT23 sebagai Biomarker Prognostik pada Adenokarsinoma Rektal: Analisis Bioinformatika Berbasis UALCAN Danang Prasetyaning Amukti; Mitha Dwi Puspitasari; Ari Widhiarso; Bayu Bakti Angga Santoso; Ria Indah Pratami
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 7 No. 2 (2026): Februari
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v7i2.1836

Abstract

 Introduction: Colorectal cancer, including READ, is one of the leading causes of cancer death worldwide. Recent studies have shown the involvement of the KRT23 gene, a member of the type I keratin family, in various malignant processes, including tumor cell proliferation, migration, and invasion. Although KRT23 expression has been studied in several types of cancer, its role in rectal cancer remains poorly understood. This study aimed to evaluate the relationship between KRT23 expression and patients' clinical characteristics and their survival. Methods: KRT23 expression data in rectal cancer patients were obtained from the UALCAN platform, which included subgroups based on race, sex, and weight status. Analysis was performed to evaluate the relationship between KRT23 expression levels and patients' clinical characteristics and their effects on survival using Kaplan-Meier curves and log-rank statistical analysis. Results: KRT23 expression was significantly increased in rectal cancer tissues compared to normal tissues. Survival analysis showed that race significantly affected the relationship between KRT23 expression and patient prognosis (p < 0.0001), especially in the Caucasian and African-American racial groups. In contrast, there was no significant difference based on gender (p = 0.97) and weight status (p = 0.64). Conclusion: High KRT23 expression is associated with better prognosis in certain racial subgroups, making it a potential candidate prognostic biomarker for rectal cancer. However, further studies with larger sample sizes are needed to strengthen these findings and understand the underlying biological mechanisms.
The Role of SLC22A1 Polymorphisms in Metformin Therapeutic Response: A Bioinformatics Based Literature Review Danang Prasetyaning Amukti; Lalu Muhammad Irham; Daru Estiningsih; Nurul Kusumawardani; Barkah Djaka Purwanto; Ria Indah Pratami; Mauritz Pandapotan Marpaung
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 9 No. 01 (2026): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v9i01.23991

Abstract

Metformin is the most common first-line therapy used in the management of type 2 diabetes mellitus (T2DM). However, therapeutic response to metformin varies between individuals, which is largely influenced by genetic factors, especially polymorphisms in the SLC22A1 gene. This gene encodes the organic cation transporter 1 (OCT1), which plays a role in the transport of metformin into hepatocytes. This literature review used a bioinformatics approach to explore the impact of SLC22A1 polymorphisms on the efficacy of metformin. Genetic and pharmacogenomic data were collected from two major databases, namely PharmGKB and GTEx Portal. Relevant polymorphic variants were identified based on data that were associated with drug response. Tissue expression analysis of SLC22A1 in GTEx was used to evaluate the biological relevance of gene expression in metformin target organs. The results showed that SLC22A1 gene expression was significantly highest in liver tissue, which plays a key role in the efficacy of metformin in T2DM patients. SLC22A1 functions as a major transporter in transporting metformin into hepatocytes, where its pharmacological action occurs. Genetic variations such as rs622342, rs594709, and rs628031 can significantly affect the expression and function of these transporters, which ultimately have a direct impact on the efficacy of metformin therapy. This study emphasizes the importance of pharmacogenomic approaches in personalized medicine for T2DM patients.
Co-Authors Ari Widhiarso Barkah Djaka Purwanto Bayu Bakti Angga Santoso Daru Estiningsih Ifa Aris Suminingtyas Kusumawardani, Nurul Lalu Muhammad Irham MAURITZ PANDAPOTAN MARPAUNG Mitha Dwi Puspitasari Nurul Kusuma Wardani Ria Indah Pratami Ria Indah Pratami Tetie Herlina Wiwi Kustio Prillia