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Brief counseling by pharmacists enhances the knowledge, perceptions, and compliance of first and second-trimester pregnant women consuming ferrous fumarate at Jetis Community Health Center of Yogyakarta Nurul Kusumawardani; Endang Darmawan; Akrom Akrom; Sulistiari Retnowati
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

In Indonesia, the prevalence of anemia during pregnancy increased from 37.1% in 2013 to 48.9% in 2018. It plays a significant part in elevated maternal mortality and perinatal rates. This research aimed to determine the influence of a brief counseling intervention by pharmacists based on the â€˜5Aâ€™ strategy that had been modified to include the knowledge, perceptions, and compliance of pregnant women with the recommended consumption of ferrous fumarate as anemia treatment and prevention. It is a quasi-experimental study with a pretest-posttest control group design. The data were collected prospectively from December 2018 to February 2019. The sample consisted of 26 respondents, divided into a control group and an intervention group. Each group comprised 13 pregnant women in their first and second trimester (ranging from 12 to 27 weeks). The knowledge, perceptions, and compliance in each group were measured on the first day of visit (Day 1; pretest) and Day 31 (posttest) after the intervention. The results showed a significant difference in average scores between the pretest and posttest in the intervention group (p<0.001 for knowledge, perceptions, and compliance parameters) but an insignificant difference in the control group (p=0.185, p=0.366, and p=0.111, respectively). Score difference or improvement was determined from the relative risk (RR) values of the three parameters (4.55, 4.54, and 10.29, respectively, with p<0.50). As a conclusion, a brief counseling intervention based on the modified â€˜5Aâ€™ strategy can enhance the knowledge, perceptions, and compliance of first and second-trimester pregnant women at Jetis Community Health Center with the proper consumption of Fe fumarate as an iron supplement.

KEPATUHAN MENGKONSUMSI SUPLEMEN ZAT BESI BERPENGARUH TERHADAP KEJADIAN ANEMIA PADA KEHAMILAN Nurul Kusumawardani
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 4, No 2 (2020)
Publisher : Alma Ata University Press

AbstrakKondisi kehamilan memiliki risiko lebih tinggi mengalami anemia defisiensi zat besi. Hal ini dikarenakan, kebutuhan zat besi meningkat secara signifikan namun tidak diimbangi dengan penyimpanan zat besi di dalam tubuh. Tujuan penelitian ini adalah mengetahui gambaran tingkat kepatuhan ibu hamil dengan metode pill count dan self report dalam mengkonsumsi suplemen zat besi serta hubungannya terhadap kejadian anemia pada kehamilan. Penelitian ini merupakan descriptive correlation study dengan rancangan case-control design, dimana sampel pada penelitian ini terbagi menjadi kelompok kasus (ibu hamil dengan anemia) dan kontrol (ibu hamil tanpa anemia). Teknik sampling yang digunakan adalah non-probability sampling dengan metode consecutive sampling, hingga didapatkan 68 responden usia kehamilan trimester III yang rutin melakukan antenatal care (ANC) sejak awal kehamilan di Puskesmas Jetis, Kota Yogyakarta pada bulan Februari 2019. Keseluruhan responden terbagi menjadi dua kelompok, masing-masing sebanyak 34 responden. Analisis statistika yang digunakan untuk merumuskan hasil penelitian ini adalah Chi-square (X2 test) dengan Spearman's rank correlation coefficient (ρ) untuk mengetahui kekuatan dan arah korelasi antara kejadian anemia dengan tingkat kepatuhan responden berdasarkan metode pill count. Hasilnya menunjukkan bahwa responden yang tidak patuh mengkonsumsi suplemen zat besi berhubungan bermakna dengan kejadian anemia (X2=11,56; p=0,001 (p<0,050)), odd ratio (OR) = 10,79; 95%CI 2,25-51,66 dan memiliki arah korelasi positif dengan kekuatan sedang (ρ=0,412, p=0,001), sehingga dapat disimpulkan bahwa ibu hamil yang tidak patuh akan berisiko 10 kali lipat mengalami anemia (Hb<11,5 g/dL) pada masa kehamilan. Berdasarkan hasil tersebut dapat diketahui bahwa pentingnya mengkonsumsi suplemen zat besi untuk mencegah terjadinya anemia pada ibu hamil.Kata Kunci: anemia, hemoglobin, kehamilan, kepatuhan, suplemen zat besi AbstractWomen with pregnancy have a higher risk of developing anemia with iron deficiency. This condition is due to the maternal body requirements for a significant iron, but the intake and storage of iron in the body are inadequate. The aim of this study was to describe the compliance of pregnant women in consuming iron supplement and correlation with anemia in pregnancy. The purpose of the study to describe the compliance of pregnant women in consuming iron supplements and its relationship with the incidence of anemia in pregnancy. This study is a descriptive correlation study with a case-control design. The sampling technique used was non-probability sampling with the consecutive sampling method, so that 68 respondents of pregnancy in their third trimester who routinely performed antenatal care (ANC) since the beginning of pregnancy at Primary Health Center Jetis, Yogyakarta City in February 2019. Chi-square statistical analysis (X2 test) with Spearman's rank correlation coefficient (ρ) to determine the strength and direction of the correlation between anemia and respondent compliance based on the pill count method. The results showed that respondents who did not adhere with iron supplements had a significant relationship with the incidence of anemia (X2 = 11.56; p-value= 0.001 (p-value<0.050)), odds ratio (OR) = 10.79; 95% CI 2.25-51.66 and has a positive correlation direction with moderate strength (ρ-value= 0.412, p-value = 0.001), so it can be concluded that pregnant women who are not adherent will have 10 times the risk of experiencing anemia (Hb 11.5 g/dL) during pregnancy. Keyword: anemia, hemoglobin, pregnancy, adherence, iron supplements

Lecturers’ and Students’ Responses toward the Implementation of the Merdeka Belajar-Kampus Merdeka (MBKM) Program at Alma Ata University Ahmad Salim; Tri Rochmadi; Yulinda Kurniasari; Rusny Istiqomah Sujono; Rosa Nikmatul Fajri; Nurul Kusumawardani; Andi Wahyudi; Muh. Mustakim
AL-ISHLAH: Jurnal Pendidikan Vol 14, No 3 (2022): AL-ISHLAH: Jurnal Pendidikan
Publisher : STAI Hubbulwathan Duri

Independent Learning-Independent Campus (MB-KM) is a policy that has been issued by the government and is contained in the Regulation of the Minister of Education and Culture Number 3 of 2020 related to the National Standards for Higher Education. Students don't only have one skill, but also several skills through the MBKM program. In addition, lecturers are required not only to teach related content but also to improve soft skills and implementation so that students can achieve the expected graduate achievement targets and be ready to work. The purpose of this study was to determine the response of students, lecturers and education staff to the MBKM program, and the implementation of the Tridharma at Alma Ata University. This type of research is qualitative cross-sectional study and data collection using a questionnaire survey online method. The sample of this study was students and lecturers at Alma Ata University, until the completion of the study, the sample size was 855 students and 114 lecturers. The survey was conducted online through the MBKM implementation questionnaire with the type of closed-ended question. The results of this study indicate that students are excited to participate in MBKM activities, particularly within the framework of the internship program and the real work lecture (KKN). In addition, it is known that there is still a low understanding of students, several lecturers, educational staff, and partners regarding policies and Standard Operating Procedures (SOP) for MBKM activities made by both the University and the Study Program level. The socialization associated with this program must be ongoing with the university community and educational partners. The response and implementation of MBKM that has been carried out well will be able to produce graduates with hard skills and soft skills who are ready to face the world of work independently, innovatively, and tough.

Analysis of Factors Affecting the Stress Level and Self-Medication Practice in Primary Dysmenorrhea in Adolescents during COVID-19 Pandemic Nurul Kusumawardani; Endang Darmawan; Jasmine Amira Hatisuci; Iftita Nuratika Ramadhanti; Rahma Sakti Oktavia; Very Ainun Fauziah; Trisna Styawaty; Ratih Nugraeni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.155-167

Background: During the novel coronavirus (COVID-19) pandemic, reports of adolescent pain and worsening of the menstrual cycle increased with increasing stress levels. Objective: Analysis of determinant factors that influence the ability to self-medication for menstrual pain, including socio-demography and medical history, to determine the effect of stress levels on the menstrual cycle of adolescent women during the COVID-19 pandemic. Methods: The method is descriptive observational, through a cross-sectional study on adolescent females in Indonesia was conducted in October-November 2020. Data collection through a simple survey method using a self-medication online questionnaire survey and the Kessler psychological distress scale (KPDS) by consecutive sampling technique. About 258 women agreed to participate in the study. The results are presented in the form of frequency and percentage (%), and the determinants are analyzed using Ï‡2-test and binary logistic regression models. Result: About 78.3% of respondents had stress during the pandemic COVID-19 with primary dysmenorrhea (70.2%), and 58.9% of respondents had low self-medication for managing primary dysmenorrhea. The predictors of self-medication understanding were the mother's education level and history of menstrual pain (p-value = 0.045; 0.005). In addition, respondents' stress levels during the COVID-19 pandemic affected their menstrual cycles (OR=5.110; 95% CI: 1.767–14.782, p-value=0.003). Conclusion: The role of pharmacists in the community and mothers as pioneers of family health is vital in increasing the understanding and implementation of the practice of self-medication for primary dysmenorrhea. This role needs to manage the stress of adolescent women. It can affect the reduction in the menstrual cycle, especially during the COVID-19 pandemic.

Pola Peresepan Antibiotik pada Pasien Komplikasi Diabetes Melitus di RSUD Panembahan Senopati Bantul Eva Nurjanah; Daru Estiningsih; Nurul Kusumawardani; Ninisita Sri Hadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1150

Diabetes Mellitus, one of the non-communicable diseases (NCDs), is the leading cause of death in addition to cardiovascular disease, cancer, and chronic respiratory disease. The Basic Health Research (Riskesdas) recorded that Yogyakarta experienced a prevalence increase of 97% in 2013-2018, the second-highest in Indonesia. Uncontrolled sugar levels cause deterioration of the immune system. This study aims to determine the pattern of prescribing antibiotics and the occurrence of comorbid complications, both infectious and non-infectious. This was a non-experimental descriptive study with a cross-sectional design. The data was collected from patient's medical records retrospectively from July to December 2019. Furthermore, 65 medical records were taken using a simple random sampling method. A descriptive statistical analysis was performed, and the results were presented as percentages. The percentage of infectious and non-infectious comorbid diabetes mellitus II in Panembahan Senopati Bantul Hospital was 22.2% and 77.8%, respectively. The prescribing pattern primarily used was ceftriaxone (23.5%). The antibiotic class mainly prescribed was cephalosporin (49%).

Analisis Hubungan Tingkat Kepatuhan Penggunaan Obat terhadap Luaran Klinis Pasien PROLANIS Program Rujuk Balik Diabetes dengan Hipertensi di Puskesmas Minggir pada Masa Pandemi COVID-19: Tingkat Kepatuhan Penggunaan Obat terhadap Luaran Klinis Pasien PROLANIS Diabetes dengan Hipertensi di Masa Pandemi COVID-19 Apristina, Ana; Nurinda, Eva; Kusumawardani, Nurul; Yugistyowati, Anafrin; Dwinta, Eliza
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.6

Kepatuhan pengobatan menjadi faktor penting pada pengobatan jangka panjang yang dapat mempengaruhi luaran klinis. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien PROLANIS Program Rujuk Balik diabetes dengan hipertensi di Puskesmas Minggir pada masa pandemi COVID-19. Metode penelitian kuantitatif non-eksperimental secara purposive sampling berjumlah 79 responden, variabel independen diukur menggunakan metode tidak langsung berupa kuesioner dan pill count, variabel dependen berupa Gula Darah Puasa (GDP), HbA1c dan tekanan darah dilihat melaui rekam medik. Analisis statistik menggunakan chi-square untuk mengetahui hubungan tingkat kepatuhan terhadap luaran klinis (p-value ≤0,05). Berdasarkan hasil karakteristik sosio-demografi responden penelitian menunjukkan mayoritas kategori usia lansia (93,7%), berstatus pendidikan tidak tamat sekolah (57%) dan status pekerjaan tidak bekerja (64,6%). Hasil penelitian menunjukkan Tingkat Kepatuhan pasien Program Pengelolaan Penyakit Kronis (PROLANIS) Program Rujuk Balik diabetes melitus tipe 2 dengan hipertensi di Puskesmas Minggir sebanyak 36 pasien (45,6%) termasuk kategori patuh dan 43 pasien (54,4%) tidak patuh menggunakan obat. Hasil Luaran klinis GDP, HbA1c dan tekanan darah sebanyak 13 pasien (16,5%) dikatakan terkontrol dan 66 pasien (83,5%) dikatakan tidak terkontrol. Tidak terdapat hubungan bermakna antara tingkat kepatuhan terhadap luaran klinis diabetes (p=0,435); dan luaran klinis hipertensi (p=0,199) serta tidak terdapat hubungan bermakna antara tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien diabetes dengan hipertensi (p=0,963). Berdasarkan hasil penelitian dapat disimpulkan bahwa tidak ada hubungan bermakna antara tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien PROLANIS Program Rujuk Balik diabetes dengan hipertensi di Puskesmas Minggir pada masa pandemi COVID-19.

Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.

Analisis Hubungan Tingkat Kepatuhan Penggunaan Obat terhadap Luaran Klinis Pasien PROLANIS Program Rujuk Balik Diabetes dengan Hipertensi di Puskesmas Minggir pada Masa Pandemi COVID-19: Tingkat Kepatuhan Penggunaan Obat terhadap Luaran Klinis Pasien PROLANIS Diabetes dengan Hipertensi di Masa Pandemi COVID-19 Apristina, Ana; Nurinda, Eva; Kusumawardani, Nurul; Yugistyowati, Anafrin; Dwinta, Eliza
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.6

Kepatuhan pengobatan menjadi faktor penting pada pengobatan jangka panjang yang dapat mempengaruhi luaran klinis. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien PROLANIS Program Rujuk Balik diabetes dengan hipertensi di Puskesmas Minggir pada masa pandemi COVID-19. Metode penelitian kuantitatif non-eksperimental secara purposive sampling berjumlah 79 responden, variabel independen diukur menggunakan metode tidak langsung berupa kuesioner dan pill count, variabel dependen berupa Gula Darah Puasa (GDP), HbA1c dan tekanan darah dilihat melaui rekam medik. Analisis statistik menggunakan chi-square untuk mengetahui hubungan tingkat kepatuhan terhadap luaran klinis (p-value ≤0,05). Berdasarkan hasil karakteristik sosio-demografi responden penelitian menunjukkan mayoritas kategori usia lansia (93,7%), berstatus pendidikan tidak tamat sekolah (57%) dan status pekerjaan tidak bekerja (64,6%). Hasil penelitian menunjukkan Tingkat Kepatuhan pasien Program Pengelolaan Penyakit Kronis (PROLANIS) Program Rujuk Balik diabetes melitus tipe 2 dengan hipertensi di Puskesmas Minggir sebanyak 36 pasien (45,6%) termasuk kategori patuh dan 43 pasien (54,4%) tidak patuh menggunakan obat. Hasil Luaran klinis GDP, HbA1c dan tekanan darah sebanyak 13 pasien (16,5%) dikatakan terkontrol dan 66 pasien (83,5%) dikatakan tidak terkontrol. Tidak terdapat hubungan bermakna antara tingkat kepatuhan terhadap luaran klinis diabetes (p=0,435); dan luaran klinis hipertensi (p=0,199) serta tidak terdapat hubungan bermakna antara tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien diabetes dengan hipertensi (p=0,963). Berdasarkan hasil penelitian dapat disimpulkan bahwa tidak ada hubungan bermakna antara tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien PROLANIS Program Rujuk Balik diabetes dengan hipertensi di Puskesmas Minggir pada masa pandemi COVID-19.

Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.

Analysis of total phenolic content and antioxidant activity of mahogany seed infusion (Swietenia mahagoni (L.) Jacq.) Pratiwi, Sindi; Emelda, Emelda; Kusumawardani, Nurul; Munir, Muhammad Abdurrahman; Azizah, Abibatul; Pothitirat, Werayut
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 4, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(4).262-272

Background: The mahogany plant (Swietenia mahagoni) is a plant used in medicine. Mahogany seeds are also efficacious as antiseptics, antioxidants, and antimicrobials. This plant contains flavonoids, saponins, tannins, essential oils, alkaloids, and anthraquinones. The higher the phenolic content in a plant, the higher the antioxidant activity. According to previous studies, it was stated that the methanol extract of mahogany seeds has good antioxidant properties, and the phenolic compounds contained in mahogany seeds can be the main contributors to antioxidant activity.Objectives: This study aims to analyze the total phenolic content, measure the inhibition concentration 50% (IC50) and determine the antioxidant activity of mahogany (Swietenia mahagoni) seed infusion.Methods: This type of research is experimental which begins with extraction using the infusion method at a temperature of 900C for 15 minutes followed by measuring the total phenolic content by reacting the infusion preparation and the Gallic acid respectively with the Follin-ciocalteu reagent. The antioxidant activity test was carried out using the DPPH (,-diphenyl--picrylhydrazyl) free radical scavenging method. Each absorbance was measured using UV-Vis Spectrophotometry. The phenolic test was measured by making a linear regression between concentration and absorbance, followed by calculating the total phenolic content. Meanwhile, the absorbance obtained for the antioxidant test was calculated by calculating the percent inhibition. The IC50 is determined by calculating the linear regression of the relationship between concentration and percent inhibition.Result: The results of the phenolic content were 2.531 ± 0.029 mg GAE/g, the IC50 value for gallic acid was 5.54 ppm, and for mahogany seed extract, the IC50 value was 47.04 ppm, which is a very strong antioxidant.Conclusion: This study concluded that the phenolic content of mahogany seed infusion extract contained phenolic compounds equivalent to 2.531 ± 0,029 mg GAE/g of gallic acid and that mahogany seed extract had very strong antioxidant activity.

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