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All Journal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) PCJN Pharmaceutical and Clinical Journal of Nusantara Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Farmasi dan Farmakoinformatika Jurnal Farmasi Galenika Journal of Pharmacy and Halal Studies (JPHS)
Ria Indah Pratami
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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 1 
Ilmu Kefarmasian Dalam Prespektif Islam dan Kemuhammadiyaan Ria Indah Pratami; Oman Fathurohman sw
An-Najat Vol. 2 No. 3 (2024): AGUSTUS - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i3.1484

Abstract

The pharmaceutical world today has developed very quickly, and this development has seen a shift in focus to current products. The principles of treatment that contain high and noble values ​​emerged from the revelation of the Koran and Islamic teachings conveyed by the Prophet Muhammad. This research aims to analyze pharmaceutical science from an Islamic and Muhammadiyah perspective, with a focus on developing a pharmaceutical practice model that is based on the ethical and moral values ​​taught by Islam. The method used is literature research with data sources from published research. Literature review involves reading books, journals, and other publications related to the research topic in order to write about the subject. Based on research findings, pharmaceutical practitioners and health institutions apply Islamic and Muhammadiyah principles in their practice, thereby making a significant contribution to improving the quality of health services and welfare of the people through an ethical, moral and sustainable approach in accordance with Islamic teachings and Muhammadiyah values
Pharmacogenomic and Bioinformatic Insights into ACE Gene Variants and Their Influence on ACE Inhibitor Response in Hypertension Amukti, Danang Prasetyaning; Ria Indah Pratami; Ismyama, Dian Farida; Puspitasari, Ade; Herlina, Tetie
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 03 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.113

Abstract

Response to angiotensin-converting enzyme inhibitors (ACEIs)-based antihypertensive therapy varies between individuals, which is largely influenced by genetic factors. The ACE gene has several polymorphisms that can affect enzyme levels and therapeutic efficacy. This study aims to explore the relationship between genetic variations in the ACE gene and response to captopril, lisinopril, ramipril, and enalapril in hypertensive patients. This study used a bioinformatics and pharmacogenomics approach by analyzing data from PharmGKB, Ensembl, and GTEx Portal. Genetic polymorphisms were analyzed to evaluate their association with ACEI efficacy using a descriptive statistical approach. Results: Four single nucleotide polymorphisms (SNPs) in the ACE gene were found to be associated with response to ACEI. Variants rs4291 and rs1799752 were associated with captopril efficacy, where the AA genotype showed a decrease in the severity of renal failure. The rs1799752 variant was also associated with lisinopril and enalapril, with the DD genotype providing greater blood pressure reduction. In addition, rs4359 and rs4344 were correlated with the efficacy of ramipril, especially in the CC+TT and AA+GG genotypes. Genetic variation in the ACE gene plays a role in determining the response to ACEI therapy. Pharmacogenetic approaches have the potential to improve the efficacy and safety of antihypertensive treatment.
ANALISIS EKSPRESI MMP1 PADA KARSINOMA PAYUDARA INVASIF DENGAN BIOINFORMATIKA MELALUI UALCAN: BIOMARKER PROGNOSTIK POTENSIAL: Analysis of MMP1 Expression in Invasive Breast Carcinoma with Bioinformatics via UALCAN : A Potential Prognostic Biomarker Danang Prasetyaning Amukti; Ria Indah Pratami
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 7 No. 1 (2025): Agustus
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v7i1.1778

Abstract

Pendahuluan: Kanker payudara invasif (BRCA) merupakan penyebab utama kematian kanker pada wanita global. Matrix Metalloproteinase-1 (MMP1), enzim pemecah matriks ekstraseluler, diduga berperan dalam invasi dan metastasis BRCA. Penelitian ini bertujuan menganalisis potensi MMP1 sebagai biomarker prognostik BRCA menggunakan pendekatan bioinformatika. Metode: Studi berbasis data TCGA ini menggunakan platform UALCAN untuk menganalisis ekspresi MMP1, metilasi promotor, dan hubungannya dengan parameter klinis. Analisis statistik meliputi uji-t, ANOVA, dan kurva Kaplan-Meier dengan uji log-rank (signifikansi p<0,05). Hasil: Ekspresi MMP1 pada jaringan tumor 5 kali lebih tinggi daripada normal (p<0,001), didukung hipometilasi promotor. Pasien dengan ekspresi tinggi MMP1 menunjukkan survival lebih buruk (p=0,0042). Variasi signifikan terlihat berdasarkan ras (terburuk pada African-American), status menopause (terburuk post-menopause), dan subtipe molekuler (HER2+ dan triple-negatif). Kesimpulan: MMP1 terbukti sebagai biomarker prognostik potensial untuk BRCA dengan implikasi klinis dalam stratifikasi risiko dan terapi target. Temuan ini mendorong penelitian lanjutan untuk validasi klinis dan pengembangan terapi spesifik.
Analisis Bioinformatika Ekspresi MIER3 sebagai Biomarker Potensial dan Target Terapeutik pada Kanker Esofagus Amukti, Danang; Ria Indah Pratami
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.389

Abstract

Esophageal cancer (ESCA) is one of the cancers with high mortality rates worldwide. Determination of prognostic biomarkers that can predict patient survival is very important to support more effective therapy management. The MIER3 gene has been reported to play a role in the regulation of gene expression and cell proliferation pathways, but its role in ESCA is still not fully understood. MIER3 gene expression data and patient clinical information were obtained from the UALCAN database based on TCGA. Survival analysis was performed using the Kaplan-Meier method to evaluate the effect of MIER3 expression levels on ESCA patient survival. Further analysis was performed by combining MIER3 expression with clinical variables such as tumor grade, race, gender, and weight status. MIER3 expression was significantly higher in tumor tissue than in normal tissue. Kaplan-Meier showed that patients with high MIER3 expression had significantly lower survival than the low expression group (p = 0.00013). The combination of MIER3 expression and clinical factors such as gender (p = 0.00046), race (p = 0.0095), and body weight (p = 0.008) also showed a prognostic relationship to survival. MIER3 has the potential as a prognostic biomarker in esophageal cancer. High MIER3 expression correlates with poor prognosis, especially when combined with certain clinical factors. These findings suggest that MIER3 may play a role in tumor progression through molecular mechanisms involving activation of proliferative pathways and inhibition of apoptotic pathways, and support the development of gene expression-based targeted therapy.
Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025 Danang Amukti; Daru Estiningsih; Tetie Herlina; Nurul Kusumawardani; Ade Puspitasari; Latifa Amalia; Ifa Aris Suminingtyas; Eva Nurinda; Sundari Desi Nuryanti; Ari Susiana Wulandari; Ria Indah Pratami
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 9 No. 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5989

Abstract

Toll-like receptor 4 (TLR4) memiliki peran penting dalam patogenesis penyakit kardiovaskular (PKV) melalui mediasi respons inflamasi. Meskipun peran molekul ini semakin dikenal, belum ada kajian bibliometrik komprehensif yang mengulas tren global publikasi terkait TLR4 dalam konteks PKV secara sistematis. Tujuan penelitian ini bertujuan untuk menganalisis dinamika publikasi ilmiah global tentang TLR4 pada PKV dalam kurun waktu 2017–2025 menggunakan pendekatan bibliometrik. Data dikumpulkan dari database Scopus dengan kata kunci “Toll-like receptor 4” dan “cardiovascular”, difilter berdasarkan judul, abstrak, dan kata kunci, serta dibatasi pada dokumen berbahasa Inggris. Sebanyak 1.939 dokumen dianalisis menggunakan perangkat lunak Bibliometrix (R) dan VOSviewer untuk mengevaluasi tren publikasi, produktivitas penulis, kontribusi negara dan institusi, pemetaan kata kunci, dan artikel yang paling berpengaruh. Tiongkok mendominasi jumlah publikasi (592 dokumen), sementara Amerika Serikat mencatat pengaruh ilmiah tertinggi melalui kolaborasi internasional dan jumlah sitasi. Penulis paling produktif adalah Li Y dan Wang Y, sedangkan institusi teratas adalah Mashhad University dan Capital Medical University. Peta kata kunci menunjukkan empat klaster utama: inflamasi-imunitas, stres oksidatif-apoptosis, metabolisme, dan model hewan. Artikel paling disitasi berasal dari jurnal bereputasi tinggi seperti Signal Transduction and Targeted Therapy dan Nature Reviews Rheumatology. TLR4 merupakan target utama dalam penelitian multidisipliner dan translasi pada penyakit kardiovaskular. Hasil studi ini dapat menjadi acuan penting untuk perumusan strategi riset lanjutan dan kolaborasi global yang lebih terarah.
Uji Efektivitas Antibakteri Ekstrak Etanol Daun Jeruk Nipis (Citrus aurantifolia) Terhadap Bakteri Shigella dysentriae Ria Indah Pratami; Silmi Kaffah; Danang Prasetyaning Amukti; Nina Salamah; Sitti Masyithah Awaluddin; Achmad Wahyudi; Asih Fatriansari
Journal of Pharmacy and Halal Studies Vol. 2 No. 1 (2024): Journal of Pharmacy and Halal Studies (JPHS)
Publisher : Edu Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70608/x3v86k38

Abstract

Penyakit Infeksi merupakan masalah kesehatan masyarakat yang sangat penting untuk diperhatikan khususnya di negara berkembang, dengan banyaknya kasus yang terjadi di Indonesia adalah diare. Daun jeruk nipis (Citrus aurantifolia) merupakan tanaman populer yang dikenal karena sifat antibakteri, antimikroba, antijamur, dan antiparasitnya. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol daun jeruk nipis terhadap bakteri Shigella dysentriae menggunakan metode difusi cakram. Hasil penelitian menunjukkan bahwa ekstrak etanol daun jeruk nipis dapat menghambat pertumbuhan bakteri Shigella dysentriae pada konsentrasi 10% dengan diameter 20,53 mm. Penelitian ini menemukan perbedaan yang signifikan pada konsentrasi ekstrak etanol yang menunjukkan bahwa ekstrak daun jeruk nipis efektif dalam menghambat bakteri Shigella dysentriae.
Tinjauan Literatur tentang Hubungan Mutasi Genetik dengan Resistensi Obat pada Mycobacterium Tuberculosis Danang Prasetyaning Amukti; Ria Indah Pratami; Gugun Gumelar
Journal of Pharmacy and Halal Studies Vol. 2 No. 1 (2024): Journal of Pharmacy and Halal Studies (JPHS)
Publisher : Edu Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70608/j8dmhg15

Abstract

Tuberkulosis (TB) adalah salah satu penyakit menular yang paling mematikan di dunia, yang disebabkan oleh bakteri Mycobacterium tuberkulosis. Menurut laporan terbaru dari Organisasi Kesehatan Dunia (WHO), sekitar 10 juta orang menderita TBC setiap tahun, dan hampir 1,5 juta di antaranya meninggal akibat penyakit ini. Resistensi obat pada M. tuberkulosis terjadi ketika bakteri mengembangkan mekanisme untuk bertahan terhadap obat-obatan yang dirancang untuk membunuh mereka. Salah satu mekanisme utama yang menyebabkan resistensi ini adalah mutasi genetik pada genom M. tuberkulosis. Penelitian ini menggunakan metode tinjauan literatur sistematis. Sumber data diperoleh dari berbagai basis data ilmiah seperti PubMed, Google Scholar, dan ScienceDirect. Hasil penelitian menunjukkan bahwa dari 100 artikel yang ditinjau, 25 artikel berhubungan langsung dengan mutasi genetik yang menyebabkan resistensi obat pada Mycobacterium tuberculosis. Analisis dari 25 artikel ini mengidentifikasi sejumlah gen dan varian spesifik yang berperan dalam mekanisme resistensi obat. Gen-gen tersebut berhubungan dengan resistensi terhadap obat-obatan seperti isoniazid, rifampicin, Pirazinamid,streptomisin dan etambutol. Pentingnya memahami mekanisme pengobatan ini untuk mengembangkan strategi pengobatan TBC yang lebih efektif dan mencegah resistensi obat yang semakin meluas, sekaligus memperkuat upaya global dalam mengatasi dan mengobati TBC.
Pemetaan Lanskap Ilmiah Penelitian Obat Herbal Indonesia (1983–2026): Analisis Bibliometrik: Mapping the Scientific Landscape of Indonesian Herbal Medicines Research (1983–2026): A Bibliometric Analysis Danang Prasetyaning Amukti; Ria Indah Pratami
Jurnal Farmasi dan Farmakoinformatika Vol. 4 No. 1 (2026)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2026.v4i1.193

Abstract

Herbal medicine research in Indonesia has experienced rapid development along with the increasing interest in natural-based treatments and the utilization of biodiversity. This study aims to map the scientific landscape of herbal medicine research in Indonesia during the period 1983–2026 using a bibliometric approach. Data were obtained from the Scopus database with keywords related to herbal medicine, traditional medicine, phytotherapy, and ethnopharmacology combined with the Indonesian context. Analysis was conducted using VOSviewer and Biblioshiny software to evaluate publication trends, journal sources, author productivity, institutional affiliations, citations, and keyword mapping. The results show 659 publications from 333 sources, with an annual growth rate of 6.5%. The publication trend has increased significantly since 2016 and peaked in 2025 with 92 articles. Keyword analysis shows the dominance of topics such as herbal medicine, plant extract, phytochemistry, and antioxidant activity, indicating that the research focus is still at the pre-clinical stage. Publication sources are dominated by proceedings such as the IOP Conference Series (35 articles) and journals such as Biodiversitas (32 articles). The most productive institutions were Airlangga University (95 publications) and Gadjah Mada University (82 publications), with an average of 4.9 authors per article and 17.91% international collaboration. The highest-impact articles received 313 citations, demonstrating the importance of publication in reputable journals. In conclusion, herbal medicine research in Indonesia has shown significant growth but is still dominated by exploratory research. Improvements in publication quality, international collaboration, and strengthening translational research are needed to support the development of evidence-based herbal medicines and enhance Indonesia's contribution globally.
Co-Authors Achmad Wahyudi Ade Puspitasari Amukti, Danang Ari Susiana Wulandari Danang Amukti Danang Prasetyaning Amukti Danang Prasetyaning Amukti Daru Estiningsih Eva Nurinda Fatriansari, Asih Gugun Gumelar Herlina, Tetie Ifa Aris Suminingtyas Ismyama, Dian Farida Kusumawardani, Nurul Latifa Amalia Nina Salamah Nuryanti, Sundari Desi Oman Fathurohman sw Puspitasari, Ade Silmi Kaffah Sitti Masyithah Awaluddin Tetie Herlina