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Cartika, Harpolia
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology

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Irritation Test of Cream Preparations Made from Purple Cabbage Extract Against Healthy Skin Using The Path Test Method Deswani, Deswani; Djuwitaningsih, Sri; Cartika, Harpolia; Malau, Paul
JURNAL INFO KESEHATAN Vol 23 No 1 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss1.1458

Abstract

Testing for skin irritation caused by new substances is a critical component of safety evaluation procedures. Pharmaceutical formulations and active ingredients intended for topical application have the potential to cause skin irritation, necessitating thorough safety assessments prior to public distribution. This study aimed to evaluate the primary irritation potential of a purple cabbage extract cream using the patch test method on healthy older adults. The experimental research involved 18 volunteers, who were administered 0.625% purple cabbage extract cream and a placebo preparation without the test substance. The test materials were applied twice daily over a period of 72 hours. Observations were conducted at baseline (0 hours) and at 24, 48, and 72 hours post-application. The degree of skin irritation was then calculated based on the recorded data. The results indicated a primary irritation index of 0.1, suggesting that the purple cabbage extract cream did not cause skin irritation. It can be concluded that the purple cabbage extract cream is safe for skin application in the tested population. Future research should explore the effects of purple cabbage cream on different skin locations, as skin sensitivity can vary across different areas of the body.
Co-Authors Deswani, Deswani Malau, Paul Sri Djuwitaningsih