Endang Mutiawati Rahayuningsih*
Department Of Neurology, School Of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department Of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia

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Clinical Characteristic Myasthenia Gravis among Indonesians Syahrul Syahrul; Endang Mutiawati; Nur Astini; Nurul Fajri; Suherman Suherman
Budapest International Research in Exact Sciences (BirEx) Journal Vol 2, No 2 (2020): Budapest International Research in Exact Sciences, April
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v2i2.1015

Abstract

Myasthenia gravis (MG) is a relatively rare autoimmune disorder on peripheral nerves where an antibody of nicotinic acetylcholine postsynaptic receptor is formed on neuromuscular junction (NMJ). MG is clinically characterized with a fluctuating muscle weakness. The incidence rate is 0.25 to 2.0 per 1,000,000 among population. 10% of the population is children and adolescents.  Over the past forty years, a mortality rate has improved in the myasthenic crisis from 75% to less than 5%. Moreover, in Indonesia, this is still considered a rare disease. This study applied a retrospective cross-sectional study design. Data were gathered from patients diagnosed and treated for myasthenia gravis admitted in the neurological emergencies in the hospital during January to November 2019. Afterwards, the follow-up clinical information was also being analyzed. 12 cases of myasthenia gravis were collected with females predominated (75%), and one male (25%) with the average age of 30-40 years. The majority (75%) had the onset of < 35 years. The patients were from various districts, with 75% referral from the district and 58% housewives. Clinically, 8% patients had the ocular myasthenia and 92% was the generalized one. The ocular myasthenia had a relatively earlier onset. As MG symptomatology bears a wide range of variability and severity, it was graded based on Osserman’s and Myasthenia Gravis Foundation of America’s (MGFA) classification. Out of all patients, 13.7% belonged to Osserman’s class 1-3 (33%) and class 4-5 (67%). Myasthenia Gravis Foundation of America (MGFA) grading calibrated the severity of each crisis. The findings were 17% crisis of milder degree and 83% of moderate to severe nature. The thyroid disorder was evident in one of the patients (8.3%). Laboratory findings were 75% patients with the increase in leukocyte count. The treatment was only 25% anticholinesterase, 50% anticholinesterase and steroid, in addition to 25% anticholinesterase and therapeutic plasma exchange (TPE). The hospital stay was (the average in days) 83% with >7 days. The myasthenia gravis reported was 12 cases. Patients’ outcome depended on the clinical condition when they first arrived in the hospital. These findings will be useful for the resource allocation and planning in health services. Many regions worldwide have few or no epidemiological data on the myasthenia gravis, and more studies are required to yield more estimates that are accurate.
Global prevalence of persistent neuromuscular symptoms and the possible pathomechanisms in COVID-19 recovered individuals: A systematic review and meta-analysis Jhonny K. Fajar; Muhammad Ilmawan; Sukamto Mamada; Endang Mutiawati; Milda Husnah; Hanifah Yusuf; Firzan Nainu; Salin Sirinam; Synat Keam; Youdiil Ophinni; Francesco Rosiello; Marhami Fahriani; Sandro GV. Rosa
Narra J Vol. 1 No. 3 (2021): December 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v1i3.48

Abstract

This study was conducted to determine the prevalence of prolonged neuromuscular symptoms, including fatigue, anosmia, headache, myalgia, and joint pain in COVID-19 survivors hospitalized with mild, moderate, or severe infections worldwide. The search was conducted up to January 30th, 2021 using three databases (PubMed, Scopus, and Web of Science) to identify potentially eligible studies. Data on study characteristics, follow-up characteristics, and severity of COVID-19 during hospitalization were collected in accordance with PRISMA guidelines. The Newcastle-Ottawa scale was used to assess the quality of relevant articles. The estimated prevalence of specific prolonged neuromuscular symptoms and the association between COVID-19 severity and occurrence of prolonged neuromuscular symptoms was analyzed wherever appropriate. Database search yielded 4,050 articles and 22 articles were included for meta-analysis. The estimated prevalence of prolonged fatigue was recorded in 21.2% (95%CI: 11.9%–34.8%) of 3,730 COVID-19 survivors. Persistent anosmia was recorded in 239 of 2,600 COVID-19 survivors (9.7%, 95%CI: 6.1%–15.2%). In 84 out of 2,412 COVID-19 survivors (8.9%, 95%CI: 3.2%–22.6%), prolonged headache was observed. A total of 53 out of 1,125 COVID-19 patients (5.6%, 95%CI: 2.1%–14.2%) complained of persistent myalgia even after being discharged from the hospital. The prevalence of prolonged joint pain was in 15.4% (95%CI: 8.2%–27.2%) of subjects. Due to data scarcity on COVID-19 severity and prolonged neuromuscular symptoms, association analysis could not be conducted. Widespread concern regarding long-term impacts of COVID-19 was raised after several studies reported prolonged symptoms in COVID-19 survivors. Numerous theories have been proposed to address this concern; however, as the research on this pandemic is still ongoing, no explanation is definitive yet. Therefore, follow-up studies in COVID-19 survivors after recovery from COVID-19 are warranted to determine the pathogenesis of prolonged symptoms. PROSPERO registration: CRD42021242332.
PENGARUH EDUKASI TERHADAP TINGKAT SELFCARE PEREMPUAN PENDERITA DIABETES MELLITUS TIPE 2 DI PUSKESMAS ACEH BESAR Rizka Amalia; Hajjul Kamil; Endang Mutiawati
Jurnal Ilmu Keperawatan Vol 10, No 1 (2022): Jurnal Ilmu Keperawatan (JIK) Volume X No.1 Januari-Juni 2022
Publisher : Jurnal Ilmu Keperawatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak Aktifitas selfcare diabetes merupakan hal penting dalam pengelolaan Diabetes Mellitus tipe 2, Namun dalam pelaksanaannya penderita diabetes seringkali tidak mengetahui tatacara perawatan mandiri diabetes yang mengakibatkan komplikasi dari penyakit semakin meningkat. Salah satu pilar penatalaksanaan diabetes adalah edukasi, dalam hal ini pemberian edukasi Aktifitas self-care diabetes diharapkan mampu memberikan informasi terkait pearawatan mandiri diabetes sehingga terbentuk perilaku perawatan mandiri diabetes yang sehat dan dinamis. Tujuan penelitian ini adalah adalah untuk mengidentifikasi pengaruh pemberian edukasi Aktifitas self-care diabetes terhadap tingkat selfcare penderita diabetes mellitus tipe 2 di puskesmas kecamatan Kuta Baro Aceh Besar. Penelitian pra experiment dengan one grup pre-test and post-test design melibatkan 52 responden perempuan anngota prolanis, Instrument penelitian yaitu Summary Diabetes Selfcare Actvitie (SDSCA). Data dianalisis menggunakan uji wilcoxon. Hasil penelitian menunjukkan terdapat terdapat perbedaan sebelum dan sesudah diberikan edukasi Aktifitas selfcare diabetes, Edukasi selfcare Aktifitas diet (P=0,00). Selfcare Aktifitas fisik (P=0,03) selfcare Aktifitas kontrol gula (P=0,00) self care Aktifitas pengobatan  (P=0,00) selfcare Aktifitas perawatan kaki (P=0,00) Artinya pemberian edukasi mempengaruhi aktifitas perawatan diri penderita diabetes sehingga Perlu dikembangkan edukasi diabetes yang terprogram terkait dengan self care diabetes.Kata Kunci : Selfcare Diabetes, Edukasi, DM tipe 2 AbstractDiabetes selfcare activity is the important things that can manage diabetes mellitus type 2. whereas in practice diabetics often do not know diabetes self-care procedures that cause complications of this disease be increasing. one of the pillars of diabetes management is education, in this case the education of diabetes selfcare activities is expected to be able to provide information related to independent diabetes selfcare so that healthy and dynamic diabetes self-care behavior is formed. the purpose of this study was to identify the effect of diabetes selfcare activity education on the level of self-care diabetes mellitus  type 2 at puskesmas kuta baro aceh besar.  the design of this research was praexperimental studies with pre experimental designs one group pretest and postest design involving 52 woman with diabetic tipe 2. The instrument used Summary Diabetes Selfcare Actvitie (SDSCA).  Data was analyzed using Wilcoxon test. Wilcoxon test resulth of this research between pre-post intervention of diabetes selfcare education was different (p-value 0,05). that significant difference of pre-post intervention of diet P-value =0,00 (P-value 0,05) , exercise P-value =0,03 (P-value 0,05), medication P-value =0,00 (P-value 0,05)  and blood-glucose control P-value =0,00 (P-value 0,05) foot care P-value =0,00 (P-value 0,05). This means that the provision of education influences the self-care activities of diabetics so that diabetes education is programmed to be developed related to diabetes self careKeywords : selfcare diabetes, education, diabetes meliitus tipe2
Peningkatan Pengetahuan, Sikap dan Perilaku Perawat Melalui Pelatihan Kredensial Profesi Keperawatan Asnawi Asnawi; Hajjul Kamil; Marthoenis Marthoenis; Marlina Marlina; Endang Mutiawati Rahayunignsih
Journal of Telenursing (JOTING) Vol 3 No 2 (2021): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v3i2.2756

Abstract

This study aims to determine the effect of nursing profession credential training on increasing nurses' knowledge, attitudes, and behavior in the surgical ward of the Aceh Government General Hospital. The method used is a quasi-experimental design with a non-control group pretest-posttest. The number of samples was 46 respondents who were selected through the total sampling method. The results showed that there was an effect of nursing profession credential training on increasing knowledge (p-value 0.0001), attitude (p-value 0.0001) and behavior (p-value 0.0001) of nurses in the operating room of the Aceh Hospital. In conclusion, nursing profession credential training can improve nurses' knowledge, attitudes, and behavior in the surgical ward of the Aceh Government General Hospital. Keywords: Credentials, Training, Nurses, Knowledge, Behavior, Attitude
A comparison study of headache characteristics and headache-associated quality-of-life of COVID-19 and non-COVID-19 patients Endang Mutiawati; Hendrix Indra Kusuma; Raisha Fathima; Syahrul Syahrul; Nasrul Musadir
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.93

Abstract

Headache is prevalent in coronavirus disease 2019 (COVID-19) patients. The main objective of this study was to compare the characteristics of COVID-19-associated headache to non-COVID-19 headache. The quality-of-life (QoL) and its associated determinants between COVID-19 and non-COVID-19 patients were also compared. A cross-sectional study was conducted in Banda Aceh, Indonesia. Headache and QoL were assessed using the International Classification of Headache Disorders, version 3 (ICHD-3), and the 36-item Short Form Health Survey (SF-36), respectively. Factors associated with poor QoL in COVID-19 and non-COVID-19 patients were examined using logistic regression. A total of 356 headache patients were included: 215 COVID-19 and 141 non-COVID-19 patients. Our data suggested that the headache in COVID-19 patients was bilateral; pain centered on one specific area with a pulsating or pressing sensation; pain intensity ranging from moderate to severe; and the frequency ranging from more than twice per week to every day. Non-COVID-19 headache was bilateral; pain centered on one side of the head resembling a migraine with pulsating or pressing sensation; mild to moderate pain intensity; and the frequency of one or two times per month. In COVID-19, low QoL was associated with unemployment status, having non-health-related jobs, having used painkillers to reduce the pain, having long duration of headache, having more frequency of attacks, and having headaches that were worsened by activities or light, and having additional symptom during a headache attach. In non-COVID-19 patients, poor QoL was associated with the use of painkillers, long duration of headache, and having conditions that aggravate the headache. To prevent long-term effects of headache associated with COVID-19, studies exploring the photobiology of headache are  needed, along with the necessity of having standardised guideline on headache prevention.