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Vivi Asfianti
Institut Kesehatan Medistra Lubuk Pakam-Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing

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Aktivitas Antiinflamasi Ekstrak Metanol Herba Puguntano (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi λ-Karagenan Vivi Asfianti; Vanny Yosepha Sagala; Andy Febriady; Suprianto; Shofian Syarifuddin
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.02

Abstract

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical exposure, or microbial agents. When excessive, this response may worsen tissue damage and require treatment. Interest in medicinal plants as alternative anti-inflammatory agents remains high because conventional nonsteroidal anti-inflammatory drugs, although effective, may cause adverse effects. Puguntano herb (Picria fel-terrae Lour.) contains flavonoids, saponins, tannins, glycosides, and steroids or triterpenoids that may contribute to anti-inflammatory activity. Objective: This study aimed to evaluate the anti-inflammatory effect of the methanolic extract of puguntano herb in male white rats with λ-carrageenan-induced paw edema and to identify the most effective tested dose. Methods: An experimental design was used in twenty-five healthy male rats divided into five groups. The negative control received 0.5% Na-CMC, the positive control received sodium diclofenac 2.25 mg/kg body weight, and the treatment groups received extract doses of 50, 100, and 200 mg/kg body weight. Acute inflammation was induced by intraplantar injection of 1% λ-carrageenan. Paw volume was measured with a digital plethysmometer for 360 minutes. Percentage of inflammation and percentage of inhibition were analyzed using one-way ANOVA followed by Tukey’s test. Results: The methanolic extract showed anti-inflammatory activity at all tested doses. A dose-dependent pattern was observed, with greater edema suppression at higher doses. The 200 mg/kg body weight dose produced the strongest effect and showed activity comparable to sodium diclofenac. Conclusion: The methanolic extract of puguntano herb demonstrated anti-inflammatory potential in this model, with the 200 mg/kg body weight dose as the most effective treatment for further preclinical study
Potensi Antipiretik Ekstrak Metanol Herba Pugun Tanoh (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi 2,4-Dinitrofenol Romansa Sianipar; Vivi Asfianti; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.04

Abstract

Background: Pugun tanoh herb (Picria fel-terrae Lour.) is a medicinal plant belonging to the family Scrophulariaceae and has traditionally been used to treat malaria, promote diuresis, relieve colic, reduce fever, and manage skin diseases. Objective: This study aimed to evaluate the antipyretic activity of the methanol extract of Pugun tanoh herb in male white rats (Rattus norvegicus) induced with 2,4-dinitrophenol and to determine the most effective dose. Methods: This experimental study used a digital thermometer to measure changes in the body temperature of rats. The extract was administered at doses of 50, 100, and 200 mg/kg body weight, with Na-CMC as the negative control and paracetamol at 20 mg/kg body weight as the positive control. Results: The results showed that the methanol extract of Pugun tanoh herb exhibited antipyretic activity. Doses of 50, 100, and 200 mg/kg body weight reduced the body temperature of rats, with mean temperatures of 37.416 °C, 36.776 °C, and 36.388 °C, respectively. Conclusion: The dose of 200 mg/kg body weight demonstrated the strongest antipyretic effect. This activity is presumed to be associated with the flavonoid content of Pugun tanoh herb.
Uji Aktivitas Antioksidan Ekstrak n-Heksan, Etil Asetat dan Metanol Herba Puguntano (Picria fel-terrae Lour.) dengan Metode DPPH Ushbah Safira; Vivi Asfianti; Samran
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.05

Abstract

Background: Antioxidants are compounds that play a role in inhibiting or reducing oxidative damage caused by free radicals. Objective: This study aimed to evaluate the characteristics of simplicia, phytochemical constituents, reflux extraction process, and antioxidant activity of puguntano herb extract using the DPPH method with UV-Vis spectrophotometry. Methods: Simplicia characterization included macroscopic examination, moisture content, water-soluble extractive value, ethanol-soluble extractive value, and total ash content. Phytochemical screening was performed using thin-layer chromatography to detect alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. Puguntano herb was extracted by reflux using n-hexane, ethyl acetate, and methanol as solvents, followed by concentration with a rotary evaporator to obtain thick extracts. Antioxidant activity was assessed using the DPPH method after 60 minutes of incubation at a wavelength of 516 nm. Results: The simplicia characterization showed a moisture content of 7.23%, water-soluble extractive value of 38.6%, ethanol-soluble extractive value of 5%, and total ash content of 10.71%. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. Conclusion: The IC50 values of the n-hexane, ethyl acetate, methanol extracts, and quercetin were 216.8478, 30.6781, 21.3478, and 4.973 µg/mL, respectively
Co-Authors Andy Febriady Debi Meilani Romansa Sianipar Samran Shofian Syarifuddin Suprianto Ushbah Safira Vanny Yosepha Sagala