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Suprianto
Institut Kesehatan Medistra Lubuk Pakam-Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing

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Validasi Metode Penetapan Kadar Monosodium Glutamat pada Mie Ayam dengan Spektrofotometri UV–Vis Setelah Derivatisasi Ninhidrin Suprianto; Effendy De Lux Putra; Samran; Siti Nurbaya; Cyndi Veronica; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.05

Abstract

Pendahuluan: Mie Ayam merupakan aneka olahan mie yang dijajakan, disajikan dan dinikmati dengan cita rasa yang sangat lezat; dijajakan dari mulai gerobak jalan, di pinggir jalan maupun tempat lesehan. Mie Ayam diolah dengan penambahan berbagai bahan tambahan pangan agar diperoleh makanan yang dapat membangkitkan selera konsumen. Mie Ayam yang disajikan harus diproses dengan benar sehingga konsumen aman setelah konsumsi makanan tersebut. Monosodium glutamate (MSG) merupakan bahan tambahan pangan yang biasa ditambahkan pada makanan untuk meningkatkan cita rasa makanan, terutama rasa lezat makanan. MSG ditambahkan pada produk pangan tidak lebih dari 10g/kg Bahan Pangan agar konsumen terjamin kesehatannya. MSG dapat diderivatisasi dengan ninhidrin sehingga penetapan kadar dapat dilakukan dengan spektrofotometri visibel. Tujuan: Menentukan kadar MSG pada Mie Ayam secara spektrofotometri UV. Metode: Penetapan kadar MSG dilakukan secara spektrofotometri UV setelah dilakukan derivatisasi dengan Ninhidrin. Hasil: Kadar MSG pada Mie diperoleh pada rentang 1,9441- 2,4726 g/kg bahan pangan dan di bawah batas maksimum 10 g /kg bahan pangan menurut EPSA. Kesimpulan: Kadar MSG pada Mie Ayam pada rentang tertentu dan masih di bawah batas maksimum.
Aktivitas Antiinflamasi Ekstrak Metanol Herba Puguntano (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi λ-Karagenan Vivi Asfianti; Vanny Yosepha Sagala; Andy Febriady; Suprianto; Shofian Syarifuddin
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.02

Abstract

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical exposure, or microbial agents. When excessive, this response may worsen tissue damage and require treatment. Interest in medicinal plants as alternative anti-inflammatory agents remains high because conventional nonsteroidal anti-inflammatory drugs, although effective, may cause adverse effects. Puguntano herb (Picria fel-terrae Lour.) contains flavonoids, saponins, tannins, glycosides, and steroids or triterpenoids that may contribute to anti-inflammatory activity. Objective: This study aimed to evaluate the anti-inflammatory effect of the methanolic extract of puguntano herb in male white rats with λ-carrageenan-induced paw edema and to identify the most effective tested dose. Methods: An experimental design was used in twenty-five healthy male rats divided into five groups. The negative control received 0.5% Na-CMC, the positive control received sodium diclofenac 2.25 mg/kg body weight, and the treatment groups received extract doses of 50, 100, and 200 mg/kg body weight. Acute inflammation was induced by intraplantar injection of 1% λ-carrageenan. Paw volume was measured with a digital plethysmometer for 360 minutes. Percentage of inflammation and percentage of inhibition were analyzed using one-way ANOVA followed by Tukey’s test. Results: The methanolic extract showed anti-inflammatory activity at all tested doses. A dose-dependent pattern was observed, with greater edema suppression at higher doses. The 200 mg/kg body weight dose produced the strongest effect and showed activity comparable to sodium diclofenac. Conclusion: The methanolic extract of puguntano herb demonstrated anti-inflammatory potential in this model, with the 200 mg/kg body weight dose as the most effective treatment for further preclinical study
Aktivitas Kombinasi Ekstrak Daun Sirsak (Annona muricata Linn) dan Kulit Buah Naga (Hylocereus polyrhizus) pada Staphylococcus aureus dan Escherichia coli Suprianto; Sri Zuwinda Zusya Pane; Sumardi
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.03

Abstract

Background: Bacterial infections caused by Staphylococcus aureus and Escherichia coli remain clinically relevant due to their ability to cause skin and gastrointestinal infections. The growing concern over antimicrobial resistance has increased interest in plant-derived antibacterial agents. Soursop leaves (Annona muricata L.) and red dragon fruit peel (Hylocereus polyrhizus) contain secondary metabolites that may contribute to bacterial growth inhibition. Objective: This study aimed to evaluate the antibacterial activity of combined ethanolic extracts of A. muricata leaves and H. polyrhizus peel against S. aureus and E. coli, and to determine the most effective extract ratio based on inhibition zone diameter. Methods: This laboratory experimental study used the disc diffusion method on Nutrient Agar medium. The plant materials were extracted by maceration using 70% ethanol. Five extract ratios were tested, namely 0.05:2.95, 0.10:2.90, 0.15:2.85, 0.20:2.80, and 0.25:2.75. Amoxicillin was used as the positive control, while distilled water served as the negative control. Inhibition zones were measured after 24 hours of incubation at 37°C. Results: The extract combinations showed weak antibacterial activity against S. aureus, with mean inhibition zones ranging from 1.08 to 3.18 mm. Against E. coli, four ratios showed weak activity, while the 0.25:2.75 ratio produced moderate inhibition with the highest mean zone of 5.18 mm. The positive control produced a strong inhibition zone of 13.13 mm, whereas the negative control showed no inhibition. Conclusion: The combination of A. muricata leaf and H. polyrhizus peel extracts demonstrated limited antibacterial activity and did not indicate a strong synergistic effect. The 0.25:2.75 ratio showed the best activity against E. coli and may be considered for further optimization using higher concentrations and more specific antibacterial assays.
Co-Authors Andy Febriady Cyndi Veronica Debi Meilani Effendy De Lux Putra, Effendy De Lux Samran Shofian Syarifuddin Siti Nurbaya Sri Zuwinda Zusya Pane Sumardi Vanny Yosepha Sagala Vivi Asfianti