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All Journal Sriwijaya Journal of Internal Medicine Crown: Journal of Dentistry and Health Research
Pham Uyen
Department of Pharmacology and Therapy, Qi-Yuen Traditional Medicine, Hanoi, Vietnam
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Impact of Uncontrolled Type 2 Diabetes Mellitus on Chronic Rhinosinusitis Severity and Treatment Outcomes: A Prospective Cohort Study in Bandung, Indonesia Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Alexander Mulya; Pham Uyen; Maria Rodriguez
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.176

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition, and type 2 diabetes mellitus (T2DM) is a known comorbidity that can exacerbate inflammatory processes. This study aimed to investigate the impact of uncontrolled T2DM on CRS severity and treatment outcomes in a cohort of patients in Bandung, Indonesia. Methods: A prospective cohort study was conducted at a private hospital in Bandung, Indonesia, from January 2020 to December 2022. Adult patients diagnosed with CRS (with or without nasal polyps) were enrolled and categorized into two groups: controlled T2DM (HbA1c ≤ 7%) and uncontrolled T2DM (HbA1c > 7%). CRS severity was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Mackay CT scoring. Treatment outcomes were evaluated at 3, 6, and 12 months post-initial treatment (medical and/or surgical) based on SNOT-22 scores, endoscopic findings, and the need for revision surgery. Results: A total of 240 patients were included (120 with controlled T2DM, 120 with uncontrolled T2DM). At baseline, the uncontrolled T2DM group had significantly higher mean SNOT-22 scores (58.5 ± 12.3 vs. 45.2 ± 10.1, p < 0.001) and Lund-Mackay CT scores (11.8 ± 3.5 vs. 8.2 ± 2.8, p < 0.001) compared to the controlled T2DM group. At 12 months, the uncontrolled T2DM group showed significantly less improvement in SNOT-22 scores (mean change: -15.4 ± 8.7 vs. -28.3 ± 9.2, p < 0.001) and a higher rate of revision surgery (18.3% vs. 5.8%, p = 0.002). Multivariate analysis revealed that uncontrolled T2DM (HbA1c > 7%) was an independent predictor of poorer treatment outcomes (OR: 3.45, 95% CI: 1.98-6.01, p < 0.001). Conclusion: Uncontrolled T2DM is associated with increased CRS severity and significantly poorer treatment outcomes in patients in Bandung, Indonesia. Effective glycemic control should be a crucial component of CRS management in patients with T2DM.
Natural Bioactive Compounds against Periodontal Matrix Metalloproteinases: A ChEMBL-LOTUS Chemoinformatics Study Alexander Mulya; Pham Uyen; Sarah Armalia; Isadora Selestine
Crown: Journal of Dentistry and Health Research Vol. 3 No. 2 (2025): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v3i2.330

Abstract

Background: Matrix metalloproteinases (MMPs), particularly MMP-8, MMP-9, and MMP-13, contribute to extracellular matrix degradation in periodontitis, but natural-product bioactivity evidence is dispersed across heterogeneous assays. Objective: This study aimed to map IC50 and Ki evidence for natural-product-associated compounds against human MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-13 and to identify structurally traceable candidates for orthogonal experimental validation. Methods: Records were extracted from ChEMBL 37 on 5 August 2026 and filtered for positive values with pChEMBL, exact relations, nM units, acceptable validity metadata, no potential-duplicate flag, and direct single-protein assay assignment (confidence score 9). Measurements were summarized by compound-target-endpoint using median pChEMBL. ChEMBL natural-product-flagged candidates were exact-matched by full InChIKey in LOTUS; a study-defined high-support occurrence tier required at least 10 taxa and two reference records. Results: Of 28,002 raw records, 7,451 met the strict criteria. The 153 flagged candidates yielded 42 LOTUS matches and 35 high-support compounds, forming 81 compound-target-endpoint pairs. Isoliquiritigenin showed IC50 values of 10.0 nM for MMP-9 and 14.13 nM for MMP-13, each from one measurement. Caffeic acid showed a median MMP-9 IC50 of 14.62 nM from two assays in one document. No high-support MMP-8 IC50 record was identified; available Ki values were 4.47 micromolar for pyrogallol and 8.71 micromolar for piceatannol. Conclusion: These signals prioritize compounds for orthogonal validation but do not establish periodontal selectivity, safety, or efficacy.
Co-Authors Aisyah Andina Rasyid Alexander Mulya Alexander Mulya Hasrita Soleiman Isadora Selestine Maria Rodriguez Sarah Armalia Zainal Abidin Hasan