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Sizka Irdianti Literature Review: Standardization of the Quality of Medicinal Plants and Leaf Extracts Based on Specific and Non-Specific Parameters Sizka Irdianti; Alifah Salsabila; Vina Vina; Syifa Aulia Putri; Yonathan Tri Atmodjo Reubun
Jurnal Ayurveda Medistra Vol 8 No 1 (2026): Jurnal Ayurveda Medistra: Jurnal Ilmiah Kesehatan
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v8i1.142

Abstract

Medicinal plants have long been used by the Indonesian people, passed down through generations, in various forms of traditional preparations. Leaves are one of the most commonly used parts of plants as raw materials for herbal medicines because they are rich in secondary metabolites such as flavonoids, alkaloids, tannins, and saponins. To ensure the quality, safety, and efficacy of traditional medicinal raw materials, a standardization process is required that adheres to the Indonesian Herbal Pharmacopoeia (FHI) and the Indonesian Materia Medica (MMI) through testing of specific and non-specific parameters. This literature review aims to compare and analyze the results of specific and non-specific parameter tests of ten types of crude drug materials and leaf extracts from medicinal plants, namely Kersen leaves (Muntingia calabura L.), Kawau leaves (Millettia sericea), Avocado leaves (Persea americana Mill.), Moringa leaves (Moringa oleifera), Lotus Leaf (Nelumbium nelumbo D.), Senggani Leaf (Melastoma malabathricum L.), Matoa Leaf (Pometia pinnata JR & G.Forst), Bidara Leaf (Ziziphus nummularia), Gatal Leaf (Laportea decumana (Roxb.) Wedd), and Dandang Gendis Leaf (Clinacanthus nutans). A literature search was conducted via the Google Scholar database using the keywords “Leaf Extract,” “Specific,” and “Non-Specific,” with the criterion that journals were published between 2018 and 2025. The review results indicate that most specific parameters—including organoleptic properties, phytochemical screening, and water-soluble and ethanol-soluble extract content—met the established standards. Meanwhile, for non-specific parameters—including moisture content, drying loss, total ash content, acid-insoluble ash content, heavy metal contamination, and microbial contamination—most results met the requirements, although some parameters in certain plants still exceeded the specified limits. This review provides a comprehensive overview of the standard quality ranges for medicinal plants and serves as a reference for the development of standardized herbal medicines in Indonesia.
Formulasi dan Karakterisasi Larutan Irigasi Berbasis Ekstrak Buah Lerak (Sapindus rarak DC.) Maria Indriati ose; Sizka Irdianti; Perdiansyah Perdiansyah; Neng Nely Widiyanti Rahma; Syifa Aulia Putri; Cesarianti Dwi Puteri Hatmoko; Feronika Evma Rahayu
Jurnal Ayurveda Medistra Vol 8 No 1 (2026): Jurnal Ayurveda Medistra: Jurnal Ilmiah Kesehatan
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v8i1.146

Abstract

The lerak fruit (Sapindus rarak DC.) is a plant that contains high levels of saponins (20–28% of dry weight) and can be developed as a natural active ingredient in solution form for wound care due to its surfactant properties and ability to inhibit microbial growth. This study aims to formulate and characterize irrigation solutions using a 25% lerak fruit extract in three different formulations: F1, consisting of the extract, sodium chloride, activated carbon, and a solvent; F2, consisting of the extract, activated carbon, and a solvent; and F3, consisting only of the extract and a solvent. Physical quality evaluation included organoleptic testing, clarity, pH, displaced volume, leakage, foam height, and specific gravity, in accordance with the provisions of the Indonesian Pharmacopoeia, 6th Edition. The results showed that all three formulations had the same sensory characteristics (reddish-brown color, distinctive aroma, liquid form), a displacement volume of 100%, and no signs of leakage. Clarity tests showed that all three formulations appeared clear but still contained submicron colloidal particles due to the presence of saponin micelles and tannin-protein aggregates. The pH values of the three formulations (F1=3.75; F2=3.84; F3=3.77) were below the normal pH range of healthy skin (4.5–5.5), so pH adjustment is necessary. Foam content tests showed good foaming ability in all formulations (F1 = 78.33%; F2 = 76.33%; F3 = 75.00%), which is related to the saponin content that acts as a natural surfactant. The specific gravity test showed that F1 had a density of 1.0084 g/mL and F2 had a density of 1.0088 g/mL, which are nearly identical to the density of water. However, F3 had a density of 0.7658 g/mL, which is significantly different and poses a risk of being hypotonic. This pattern is related to the presence of activated carbon in the formula. Overall, F1 exhibits the most balanced physical properties compared to the other three formulations. However, all formulations still require pH adjustment and further purification before they can be developed into candidate burn irrigation solutions derived from natural ingredients that possess good quality, stability, and safety.