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Formulasi Sediaan Gel Sari Buah Belimbing Wuluh (Averrhoa bilimbi L.) menggunakan Iota Karaginan sebagai Gelling Agent dan Uji Aktivitas terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis Silvyana, Annysa Ellycornia; Octaviani, Adinda Tri; Reubun, Yonathan Tri Atmodjo
Jurnal Dunia Farmasi Vol 8, No 3 (2024): Edisi Agustus
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i3.6127

Pendahuluan: Buah belimbing wuluh mengandung zat nutrisi yang banyak seperti fenol dan flavonoid yang mempunyai aktivitas sebagai antijerawat. Tujuan : Penelitian ini bertujuan untuk mengetahui stabilitas sediaan gel sari buah belimbing wuluh dan aktivitasnya terhadap bakteri penyebab jerawat. Pada penelitian ini terdapat 3 formula gel dengan konsentrasi sari buah belimbing wuluh yang berbeda yaitu 50%, 25%, dan 10%. Metode: Pada penelitian ini sari buah belimbing wuluh diformulasikan dalam bentuk sediaan gel dengan iota karaginan sebagai gelling agent. Tiap formula gel di evaluasi meliputi pengamatan organoleptik, pH, homogenitas, viskositas, dan uji stabilitas fisik dengan metode shelf-life dan sentrifugasi, serta uji aktivitas antibakteri. Hasil: Berdasarkan hasil, semakin besar konsentrasi sari buah belimbing wuluh warna gel semakin tua, pH semakin asam dan viskositas semakin besar. Dan pada hasil uji statistik LSD aktivitas antibakteri didapatkan hasil KHM terbaik yaitu pada formula 1 (50%) dengan luas diameter zona hambat rata-rata 8,68 mm terhadap bakteri Propionibacterium acne dan 9,34 mm terhadap bakteri Staphylococcus epidermidis yang mendekati kontrol positif. Kesimpulan: Disimpulkan bahwa semakin besar konsentrasi sari buah belimbing wuluh semakin besar dimeter zona hambat yang terbentuk. Ketiga formula dapat menghambat pertumbuhan bakteri Propionibacterium acne dan Staphylococcus epidermidis

Perbandingan Aktivitas Penerapan Prolanis Diabetes Melitus Pada Dua Puskesmas Kota Bekasi Silvyana, Annysa Ellycornia; Warti, Lia; Rahayu, Feronika Evma; Reubun, Yonathan Tri Atmodjo; Muhaereni, Desweri
Jurnal Farmasi Higea Vol 15, No 2 (2023)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v15i2.545

Program Pengelolaan Penyakit Kronis (Prolanis) adalah program pemerintah yang bertujuan untuk mendorong peserta penyakit kronis mencapai kualitas hidup yang optimal. Pelaksanaan Prolanis pada suatu Fasilitas Kesehatan kemungkinan berbeda dengan Fasilitas Kesehatan lainnya, untuk mengetahui perbedaannya perlu dilakukan perbandingan deskriptif antar Fasilitas Kesehatan. Penelitian ini bertujuan untuk membandingkan aktivitas penerapan Prolanis Diabetes Melitus di Puskesmas A dan Puskesmas B Kota Bekasi yang dapat digunakan sebagai dasar pertimbangan kebijakan selanjutnya. Metode pada penelitian ini adalah analitik observasional secara deskriptif dan penelitian dilaksanakan di Puskesmas A dan Puskesmas B Kota Bekasi dalam kurun waktu selama 3 (tiga) bulan. Aktivitas penerapan Prolanis yang dibandingkan meliputi karakteristik sumber daya manusia (SDM) tenaga Prolanis, frekuensi sms gateway, kualitas sms gateway, kualitas materi edukasi dan ketersediaan jenis obat DM. Hasil penelitian menunjukkan bahwa aktivitas penerapan Prolanis di Puskesmas A lebih besar dibandingkan Puskesmas B, dimana karakteristik SDM tenaga Prolanis, frekuensi sms gateway dan ketersediaan obat DM di kedua Puskesmas tidak berbeda. Kualitas sms gateway dan kualitas materi edukasi Puskesmas A lebih besar dibandingkan Puskesmas B sehingga penerapan Prolanis di Puskesmas A lebih baik dibandingkan Puskesmas B. Hasil penelitian ini diharapkan dapat digunakan untuk meningkatkan pelaksanaan program Prolanis BPJS di setiap Puskesmas.

SOURSLEPINE SEBAGAI UPAYA PENURUNAN KADAR ASAM URAT PADA MASYARAKAT RT004/RW003 KELURAHAN SEPANJANG JAYA Bunga, Dinda Nur Fajri Hidayati; Reubun, Yonathan Tri Atmodjo; Nisa, Hainun; Siregar, Renince; I Ratnah; Octaviani, Lidia
PROFICIO Vol. 6 No. 1 (2025): PROFICIO : Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v6i1.4032

Masalah kesehatan terkait metabolisme dan penyakit kronis seperti asam urat, kolesterol tinggi, hipertensi, dan diabetes melitus dapat diatasi dengan meningkatkan prevalensi gaya hidup tidak sehat dan pola makan yang buruk. metode non farmakologis atau dengan cara praktik pengobatan tradisional telah mengidentifikasi sejumlah bahan alami yang memiliki potensi terapeutik untuk mengatasi AKHD. Di antara bahan-bahan tersebut, buah nanas (Ananas comosus (L.) Merr.) dan daun sirsak (Annona muricata L.) muncul sebagai bahan yang alami serta menjanjikan dalam mengelola dan mengurangi risiko kondisi kesehatan AKHD. Penelitian ini bertujuan untuk memberikan wawasan tentang bagaimana kombinasi bahan alami ini dapat dimanfaatkan dalam menurunkan asam urat, kolesterol, hipertensi, serta diabetes dan sebagai bagian dari strategi kesehatan holistik. Metode yang digunakan adalah pengabdian kepada masyarakat. Penyakit Tidak Menular (PTM) seperti asam urat, kolesterol tinggi, hipertensi, dan diabetes melitus merupakan masalah kesehatan serius yang dapat dikelola melalui kombinasi gaya hidup sehat dan penggunaan bahan alami seperti nanas dan daun sirsak. Kombinasi ini terbukti efektif dalam mengurangi risiko dan mengelola gejala penyakit-penyakit tersebut.

EVALUASI SEDIAAN SABUN MANDI CAIR EKSTRAK ETANOL DAUN JAMBU BOL (Syizigium malaccense L.) Reubun, Yonathan Tri Atmodjo; Batubara, Kevin Septiyanto
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p55-60

Bath soap is a skin care cosmetic product that can moisturize and protect the skin from sunlight and dirt that comes from outside. Of the various forms of soap preparations on the market, one type of soap that is currently being produced is in liquid dosage form because its use is more practical and the form is more attractive than other forms of soap. The use of natural ingredients as bath soap has been widely used in several soap products, one of the plants that can be used as an active ingredient in liquid soap is guava leaves. The purpose of this study was to determine the antioxidant activity of the ethanol extract of guava leaves (Syizigium malaccense L.) in liquid body soap preparations. The method used in this study was extraction using 96% ethanol solvent and the formulation of liquid bath soap was carried out, after which tests were carried out which included organoleptic tests, foam height tests, specific gravity tests, stability tests, and antioxidant activity tests. The results showed that the ethanol extract liquid bath soap of guava leaves is brown in color, liquid in shape, has a characteristic odor, and has a smooth texture. The foam height test result was 2 cm, the specific gravity test result was 1.020 g/mL and the antioxidant activity test result for the guava bol ethanol extract liquid bath soap was 9.6898. The conclusion of this study is that guava leaf extract can be used as a liquid bath soap preparation and has a good inhibitory concentration based on the results.

Pengujian Toksisitas Akut Pada Obat Bahan Alam Reubun, Yonathan Tri Atmodjo
Jurnal Ayurveda Medistra Vol 2 No 2 (2020): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v2i2.29

Toxicity tests need to be carried out on a drug product to be marketed. This initial test (screening test) is very important pharmacologically and toxicologically because it will be used for consideration of determining the dosage, the time span of administration and its application. Herbal medicine is a preparation of traditional medicine which until now its use is still needed by people in Indonesia. The toxicity testing method was chosen based on the Organization for Economic Co-operation and Development (OECD) guidelines. This method is a standard method that is recognized by many countries. Europe which is a member of the OECD. The main strengths of this method are the small amount of rodents used and the relatively fast testing time based on 3R principles. in a journal review, LD50 results were obtained in various plants, namely 0.2g / kg BW, 2g / kg BW, 3.91 g / kgBW, 3.91 g / kgBB, 4.9g / kgBW, 5g / kg BW, 16g / kg BW, and 22.41 g / kg BW. The conclusion from this test is the value of the toxic dose of herbal medicine is> 50-300 mg / kg bw as stated in Annex 2c: OECD / OCE.

UJI PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK BENALU TEH (Scurrula oortiana Dans.) Reubun, Yonathan Tri Atmodjo
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.5977

The tea mistletoe plant (Scurrula oortiana Dans.) has been widely used by the community in treating diseases both modernly and traditionally. Mistletoe tea is also known to have pharmacological effects so it can be used in various diseases such as hypertension, gout, and prevention of Alzheimer's disease. The aim of this research was to determine the specific and non-specific parameter tests of mistletoe tea extract which were extracted using 96% ethanol, then carried out phytochemical screening tests, macroscopic and microscopic tests as well as testing specific and non-specific parameters. Based on the research results, it was found that the yield of mistletoe tea extract was 37.237%, specific and non-specific parameter testing showed that the drying loss value was 4,32%, the water content was 4,94%, the ethanol soluble extract content was 59,20%. Based on the test results, the ethanol extract of mistletoe tea meets the specific and non-specific parameter tests

POTENSI EKSTRAK BENALU TEH (Scurrula oortiana Dans.) TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis DAN Staphylococcus aureus Reubun, Yonathan Tri Atmodjo; Silvyana, Annysa Ellycornia; Warti, Lia; Octaviani, Adinda Tri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12, No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.919

Acne is a disease in which there is a buildup of skin oil glands which results in clogged skin pores, causing excess fat deposits. Bacteria such as Staphylococcus epidermidis and Staphylococcus aureus are the main factors in the emergence of this acne disease. The use of natural medicine can be used to test the inhibitory activity of both bacteria, one of which is tea mistletoe. The purpose of this study was to obtain the inhibitory activity of bacteria such as Staphylococcus epidermidis and Staphylococcus aureus from tea mistletoe extract using the liquid dilution method, namely MIC and MBC. The concentrations used consisted of 100000ppm, 50000 ppm, 25000ppm, 12500 ppm, 6250ppm, and 3125ppm. The MIC method is based on the turbidity or clarity of the test solution, while the MBC is based on the concentration of the extract in the media used. The results of the study showed that tea mistletoe extract has the potential to inhibit at 50,000ppm and above on both bacteria with the MIC method and kill at a concentration of 50,000ppm on S.aureus bacteria and 25,000ppm on S.epidermidis. The conclusion of this study is that tea mistletoe extract has the potential to inhibit and kill S.epidermidis and S.aureus bacteria at a concentration of 50,000ppm on the MIC and 25,000ppm on the MBC method.

POTENSI EKSTRAK BENALU TEH (Scurrula oortiana Dans.) TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis DAN Staphylococcus aureus Reubun, Yonathan Tri Atmodjo; Silvyana, Annysa Ellycornia; Warti, Lia; Octaviani, Adinda Tri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12 No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.919

Acne is a disease in which there is a buildup of skin oil glands which results in clogged skin pores, causing excess fat deposits. Bacteria such as Staphylococcus epidermidis and Staphylococcus aureus are the main factors in the emergence of this acne disease. The use of natural medicine can be used to test the inhibitory activity of both bacteria, one of which is tea mistletoe. The purpose of this study was to obtain the inhibitory activity of bacteria such as Staphylococcus epidermidis and Staphylococcus aureus from tea mistletoe extract using the liquid dilution method, namely MIC and MBC. The concentrations used consisted of 100000ppm, 50000 ppm, 25000ppm, 12500 ppm, 6250ppm, and 3125ppm. The MIC method is based on the turbidity or clarity of the test solution, while the MBC is based on the concentration of the extract in the media used. The results of the study showed that tea mistletoe extract has the potential to inhibit at 50,000ppm and above on both bacteria with the MIC method and kill at a concentration of 50,000ppm on S.aureus bacteria and 25,000ppm on S.epidermidis. The conclusion of this study is that tea mistletoe extract has the potential to inhibit and kill S.epidermidis and S.aureus bacteria at a concentration of 50,000ppm on the MIC and 25,000ppm on the MBC method.

A review: Utilization of Herbal Medicines in Alzheimer's Disease from Three Plants in Indonesia Reubun, Yonathan Tri Atmodjo
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.4197

Alzheimer's disease is a disease in which brain damage is characterized by a decrease in attention, memory, and personality. Personality changes often occur when sufferers become less spontaneous, more apathetic, and withdrawn from their environment. The use of chemical drugs derived from the synthesis of natural drugs is approved for clinical use for Alzheimer's patients. Synthesis from natural materials is carried out because of the many chemical compounds contained in plants which have various biological and pharmacological effects. As for the use of natural medicines that are efficacious as antioxidants, anticoagulants, and anti-inflammatories, they are targets in the prevention of Alzheimer's disease where from these effects they can inhibit the acetylcholinesterase enzyme that plays a role in neurotransmitter damage. This journal review aims to maximize the use of natural medicines that have antioxidant effects from plants such as turmeric (Curcuma longa L.), gotu kola (Centella asiatica L.) and Kelor leaves (Moringa oleifera Lam.) so that these three plants are expected to have an effect. potential in the prevention of Alzheimer's disease which will be discussed extensively.

Analisis kuersetin pada ekstrak benalu teh (Scurrula oortiana Dans.) secara kuantitatif Silvyana, Annysa Ellycornia; Reubun, Yonathan Tri Atmodjo; Warti, Lia; Simangunsong, Lidia Octaviani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.575

Indonesia has a variety of plants that are useful as medicine. One is the Tea Mistletoe plant (Scurrula oortiana Dans.). This plant contains flavonoid compounds that are effective as antioxidants, especially in the form of quercetin. Quercetin in the tea mistletoe plant can prevent cell damage caused by free radicals, where cells need this antioxidant to avoid the harmful effects of excessive reactive oxygen species (ROS) production and prevent damage to immune cells. This study aims to analyze the levels of quercetin in Tea Mistletoe extract using quantitative analysis methods such as thin-layer chromatography and UV-Vis spectrophotometry. Tea Mistletoe powder was extracted by maceration with 96% ethanol solvent and then concentrated using a rotary evaporator and water bath. The thick extract obtained was then tested for phytochemical screening and specific and non-specific parameters. Analysis of flavonoid quercetin compounds was carried out using a thin layer chromatography method using a mobile phase of a mixture of chloroform, ethyl acetate, and n-butanol with a ratio of 5:4:1 and a stationary phase of Silica Gel GF₂₅₄. Determination of flavonoid levels was carried out using UV-Vis spectrophotometry at a wavelength of 428 nm. The results of this study indicate that the Mistletoe Tea plant contains flavonoids, alkaloids, steroids, tannins, saponins, phenolics, and glycosides. All test parameters meet the specified requirements. The thin layer chromatography test showed the Rf value of the Mistletoe Tea extract of 0.78. The linearity test showed a correlation value (r) = 0.9988 with a total flavonoid compound content of 372.250 mg QE/g extract, or a percentage of 37.225%.

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