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Saryono Saryono
Universitas Riau, Pekanbaru
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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EFFECT OF INULIN EXTRACT FROM DAHLIA TUBER (dahlia variabilis) ON CORONARY ARTERY HISTOPATHOLOGY IN RATS WITH TYPE 2 DIABETES MELLITUS (DM) Zikrilla mayuli Hopi; Ismawati Ismawati; Saryono Saryono; Ilhami Romus; Veni Dayu Putri; Sri Yanti; Fitri Dyna
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.3734

Abstract

Atherosclerosis in diabetes mellitus (DM) patients is prevented by using inulin to increase glucose metabolism and reduce cholesterol synthesis. Therefore, this research aimed to analyze dahlia tuber inulin extract to determine the effect on coronary artery histopathology in type 2 DM rats. A total of 20 male Wistar rats were divided into five groups, namely negative control without treatment, DM, DM + 0.5 mg/gBW/day inulin extract, DM + 1 mg/gBW/day inulin extract, and DM + 1.5 mg/gBW/day inulin extract. Furthermore, DM induction was carried out by administering 60 mg/kgBB streptozotocin and 120 mg/kgBB nicotinamide. The results of coronary artery histopathology readings showed that the highest and lowest scores of atherosclerosis were in Groups II (0,91±0,17) and V (0,08±0,1), respectively. Data analysis using Kruskal Wallis test reported significant results (p<0.05), while Mann-Whitney test showed differences between control and DM, DM, and inulin groups (III, IV, V). In this context, the administration of dahlia tuber inulin extract to rats induced by Type 2 DM prevented atherosclerosis in histopathological image of coronary artery.
EFFECT OF DAHLIA TUBER INULIN EXTRACT ON THE THICKNESS OF THE THORACIC AORTIC TUNICA INTIMA-MEDIA IN TYPE 2 DIABETIC RATS MODEL Cantika Natswa Deanra; Ismawati Ismawati; Saryono Saryono; Desby Juananda; Suci Anggraini; Timotius Agung S; Veni Dayu Putri; Sri Yanti; Fitri Dyna
Biomedika Vol 18, No 1 (2026): Biomedika February 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v18i1.4218

Abstract

Inulin is a natural polysaccharide that improves glucose metabolism and reduces cholesterol levels through the formation of short-chain fatty acids, which may contribute to preventing atherosclerosis in type 2 diabetes mellitus (T2DM). Therefore, this study aimed to evaluate the effect of dahlia tuber inulin extract on the thickness of the thoracic aortic tunica intima-media (TIM) in T2DM-induced rats. A total of 20 male Wistar rats were divided into five groups: control, T2DM, T2DM + 0.5 mg/gBW/day inulin extract, T2DM + 1.0 mg/gBW/day inulin extract, and T2DM + 1.5 mg/gBW/day inulin extract. T2DM induction was performed using 60 mg/kgBW streptozotocin and 120 mg/kgBW nicotinamide. Measurement of TIM thickness was conducted using a Leica light microscope with hematoxylin-eosin staining. The results showed no statistically significant differences among the groups (p = 0.051), although a decreasing trend in TIM thickness was observed at the 1.5 mg/gBW/day dose. In this context, dahlia tuber inulin extract demonstrated a tendency to reduce TIM thickness in T2DM-induced rats.
Co-Authors Cantika Natswa Deanra Desby Juananda Fitri Dyna Fitri Dyna Ilhami Romus Ismawati ismawati Sri Yanti Sri Yanti Suci Anggraini Timotius Agung S Veni Dayu Putri Veni Dayu Putri Zikrilla mayuli Hopi