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All Journal KOLONI
Jauharotul Firdausiyah
Universitas Muhammadiyah Kudus
Civil Engineering, Building, Construction & Architecture Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Tinjauan Naratif: Bawang Hitam (Allium sativum L.) sebagai Agen Nefroprotektif dan Perubahan Berat Badan pada Model Nefrotoksisitas Gentamisin Jauharotul Firdausiyah; Riana Putri Rahmawati; Intan Adevia Rosnarita
KOLONI Vol. 5 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i2.886

Abstract

Black garlic is the product of fermenting fresh garlic (Allium sativum L.), which is rich in bioactive compounds such as S-allyl cysteine, polyphenols, and flavonoids with antioxidant and anti-inflammatory activities. These compounds have potential as nephroprotectors against gentamicin-induced kidney damage. This narrative review seeks to consolidate evidence regarding black garlic's nephroprotective mechanisms, dose-response patterns in gentamicin-induced nephrotoxicity, and its impact on body weight variations. Literature was sourced from PubMed, ScienceDirect, Google Scholar, and Sinta, covering the publication period 2020–2025, using the keywords black garlic; nephroprotective; nephrotoxicity; and Allium sativum. The results of the review indicate that S-allyl cysteine and flavonoids act by inhibiting ROS and increasing SOD, GPx, and CAT; suppressing NF-kB accompanied by a decrease in TNF-alpha and IL-6; regulation of the Bcl-2/Bax ratio along with caspase-3 suppression, plus enhanced renal hemodynamics through nitric oxide.
Co-Authors Intan Adevia Rosnarita Riana Putri Rahmawati