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All Journal Majalah Farmaseutik PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Abdi Insani Jurnal Kesehatan Tambusai Nusantara Hasana Journal International Journal of Health and Pharmaceutical (IJHP) IJF (Indonesia Jurnal Farmasi) Indonesian Journal of Pharmacology and Therapy Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Jurnal Abdimas Indonesia
Intan Adevia Rosnarita
Universitas Muhammadiyah Kudus
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Evaluasi Penggunaan Heparin dan Enoxaparin Sebagai Antikoagulan Profilaksis pada Pasien COVID-19 Rosnarita, Intan Adevia; Zaimatuddunia, Irma; Yasin, Nanang Munif; Ikawati, Zullies
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.89846

Abstract

Koagulopati merupakan kondisi yang kerap dialami oleh pasien positif COVID-19. Kondisi ini berhubungan dengan resiko terjadinya trombosis serta kematian pada pasien COVID-19. Data penggunaan kedua antikoagulan profilaksis yakni heparin dan enoxaparin didapatkan di RSUD dr. Loemnono Hadi Kudus, dengan melihat nilai laboratorium yakni kadar D-dimer pasien sebagai evaluasi terkait efektivitas penggunaan obat, dan episode kejadian perdarahan sebagai evaluasi terkait profil keamanan kedua obat tersebut. Penelusuran data dilakukan secara retrospektif yakni pasien COVID-19 yang mendapatkan perawatan di rumah sakit mulai tahun 2020 hingga 2022. Metode penelitian ini adalah kohort observasional menggunakan 127 sampel yang memenuhi kriteria eksklusi dan inklusi, dengan 55 data pada kelompok heparin dan 72 pada enoxaparin. Analisis efektivitas menggunakan uji Mann-Whitney menunjukkan terdapat penurunan kadar D-dimer yang signifikan pada pasien yang menggunakan antikoagulan enoxaparin  (p-value < 0.05) sedangkan pada pasien yang mendapatkan heparin tidak menunjukkan penurunan yang signifikan (p-value > 0.05). Berdasarkan evaluasi keamanan penggunaan kedua antikoagulan, enoxaparin juga memiliki insidensi kejadian perdarahan yang lebih kecil (33.3%) dibandingkan heparin (40.0%). Kondisi perdarahan yang paling sering dialami pasien COVID-19 yang menerima antikoagulan profilaksis adalah batuk darah atau hemoptisis (6.3%). Namun secara statistik tidak terdapat perbedaan yang signifikan pada kejadian perdarahan antar kedua kelompok obat (p-value > 0.05).
Safety evaluation of Oral NSAID Treatment on Blood Pressure in Osteoarthritis Patients: Preventive study to Cardiovascular Events Rosnarita, Intan Adevia; Khudzaifi, Muhammad; Priswa, Nindya
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.103508

Abstract

Osteoarthritis (OA) is a degenerative joint disorder primarily affecting weight-bearing joints, causing pain, stiffness, and reduced mobility. Although there is no cure, symptom management focuses on pain relief and inflammation reduction, often through the use of nonsteroidal anti-inflammatory drugs (NSAIDs). However, NSAIDs are known to increase blood pressure, which poses concerns for long-term use, especially in patients with pre-existing cardiovascular risk factors. Given the chronic nature of OA and the common prescription of long-term NSAID therapy, it is important to assess their impact on blood pressure and cardiovascular health. This study aimed to evaluate the safety of oral NSAID therapy in terms of its effects on blood pressure in osteoarthritis patients at Dr. Moewardi Surakarta Regional General Hospital. An observational descriptive design was used with purposive sampling, analyzing data retrospectively from 35 OA patients receiving outpatient treatment for three months. The Wilcoxon signed-rank test was applied to assess changes in blood pressure, with statistical significance set at p<0.05. Results showed a significant increase in both systolic (11.3 ± 7.9 mmHg, p<0.05) and diastolic blood pressure (8.9 ± 7.0 mmHg, p<0.05) following NSAID use over the 3-month period. These findings highlight the need for careful monitoring of blood pressure in OA patients on long-term NSAID therapy, particularly those at higher cardiovascular risk. Long-term safety assessments are essential when considering NSAID treatment, and alternative therapeutic options should be considered for high-risk patients.
PENINGKATAN KESEHATAN HOLISTIK MELALUI EDUKASI PEMBUATAN SIROP HERBAL “SiHebat” KEPADA MASYARAKAT Fadel, Muhammad Nurul; Besan, Emma Jayanti; Rosnarita, Intan Adevia; Yuliasari, Aulia Wahyu; Besan, Ulfa Nabila
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2093

Abstract

The diversity of herbal plants around us is a potential that has not been optimally utilized. The Nasyiatul Aisyiyah Branch Leadership for the 2024 period requires socialization and education related to health as part of filling the routine monthly religious study activities. This community service program aims to provide education to the Nasyiatul Aisyiyah group in Getas Pejaten, Kudus Regency, regarding the production process and utilization of "SiHebat" herbal syrup based on local plants such as ginger, turmeric, temulawak, and lemongrass, which have various health benefits. Educational activities are carried out through the delivery of material using power point presentation media, with a participatory method that includes a pre-test, material presentation, presentation of herbal syrup making material, and a post-test. The results of the activity showed a significant increase in participants' understanding of the use of herbal plants for health, as indicated by an increase in the average post-test score compared to the pre-test. In addition to providing education, this program also aims to encourage community independence in utilizing local natural resources and opening up business opportunities based on herbal products, in addition it can be used by the community as a reference for developing a product that can increase independence, especially in entrepreneurship. The success of the program is measured through the enthusiasm of the participants, increased knowledge, and the ability to instill the making of herbal syrup, from the results of the Pre-test and Post-test, an increase in community knowledge was obtained in understanding starting from raw materials, efficacy and how to make and rules for using efficacious herbal syrup. From the results of community service in making efficacious herbal syrup, it can provide information and benefits to the community in developing innovations in making herbal preparations, especially in making herbal syrup and in the future this program can be further developed through product diversification and joint research to optimize the benefits of herbal plants for public health.
EFEKTIVITAS EDUKASI BEYOND USE DATE SALEP KULIT DAN MATA TERHADAP TINGKAT PENGETAHUAN MASYARAKAT DESA PECANGAAN KULON Apriliasari, Fiona; Eko Retnowati; Intan Adevia Rosnarita
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1528

Abstract

Beyond Use Date (BUD) is the time limit for using a medication after the packaging is opened or after compounding is completed. Public understanding of BUD, especially for topical skin and eye ointments, remains low. This condition may decrease the effectiveness of treatment and increase the risk of side effects. The aim of this study was to compare the effectiveness of educational media leaflets and videos in improving public knowledge about BUD. This study used a quasi-experimental design with a pretest-posttest approach, involving three groups: leaflet, video, and control. A total of 366 respondents were selected using purposive sampling. The educational intervention was conducted over seven days, and knowledge was measured using a questionnaire that had been tested for validity and reliability. Data were analyzed using the Wilcoxon Signed Rank Test to assess changes in knowledge before and after the intervention, and the Mann-Whitney U Test to compare the effectiveness between media. The results show a significant increase in knowledge after the intervention, particularly in the leaflet group (61.50) and video group (60.50), while the control group shows a decrease (57.85). The Mann-Whitney U Test indicates that leaflets are more effective than videos (p = 0.000), with the highest mean rank found in the leaflet group (138.41). It can be concluded that education using leaflet media is more effective in increasing public knowledge about BUD, as it is easier to understand, can be read repeatedly, and allows direct interaction during health education sessions.
Analysis of The Demographic Characteristics of The Community And Patterns of Use Of Antibiotic Processing Methods In Kebonagung Village, Demak Alfarizi, Nauval; Suriyadi Muslim, Ahmad; Adevia Rosnarita, Intan
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 3 (2025): August 2025 (Indonesia - Malaysia)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i3.420

Abstract

Irrational antibiotic use remains a serious challenge in efforts to control bacterial resistance globally. One form of this irrational use is the purchase of antibiotics without a prescription, which is still widespread in various regions, including rural areas such as Kebonagung Village, Demak Regency. Lack of supervision and community demographic characteristics also influence antibiotic acquisition methods. This study aims to determine the relationship between demographic characteristics and antibiotic use patterns on antibiotic acquisition methods in the community of Kebonagung Village. The research method used was an observational analytic study with a cross-sectional design. A total of 118 respondents were selected using a purposive sampling technique. Data were collected through questionnaires and analyzed using the Chi-square test with a significance level of 0.05. The analysis results showed a significant relationship between age (p = 0.011), education level (p = 0.015), and type of employment (p = 0.006) with antibiotic acquisition methods. Gender did not show a significant relationship (p = 0.138). The use pattern in this study was defined limitedly based on the type of antibiotic used according to the WHO AWaRe classification, as well as the reasons for antibiotic use based on perceived symptoms. The type of antibiotic based on the WHO AWaRe classification showed a significant relationship with the method of antibiotic acquisition (p = 0.001), with the finding that Access category antibiotics were more often obtained without a prescription, while the Reserve category was entirely obtained with a prescription. The analysis showed that there was no significant relationship between the reason for antibiotic use based on perceived symptoms and the method of antibiotic acquisition (p = 0.616). The results showed that age, education level, occupation, and type of antibiotic showed a significant relationship with the method of antibiotic acquisition, while gender and the reason for antibiotic use based on perceived symptoms did not show a significant relationship. These findings can be the basis for developing educational interventions to increase public awareness of how to obtain appropriate antibiotics, in order to prevent inappropriate access and support resistance prevention efforts at the community level.
ANALISIS KUALITAS HIDUP DAN HUBUNGANNYA DENGAN TINGKAT KEKAMBUHAN PADA PASIEN GANGGUAN JIWA DI RSUD SUNAN KALIJAGA DEMAK Rengganis, Mutiara; Etikasari, Ria; Rosnarita, Intan Adevia
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.48341

Abstract

Penyakit gangguan jiwa menjadi masalah kesehatan karena dapat mempengaruhi kualitas hidup pasien. Beberapa jenis gangguan jiwa adalah depresi, bipolar dan schizofrenia. Faktor yang dapat menyebabkan kekambuhan pada pasien gangguan jiwa diantaranya adalah dukungan keluarga, kepatuhan minum obat, kualitas hidup dan pengalaman hidup. Tujuan penelitian ini adalah untuk menganalisis hubungan kualitas hidup dengan tingkat kekambuhan pada pasien gangguan jiwa. Jenis penelitian ini adalah observasional analitik dengan pendekatan kohort retrospektif untuk pencarian data klinis di rekam medis dan cross sectional untuk mendapatkan data kualitas hidup menggunakan kuesioner EQ-5D-5L. Penelitian ini dilakukan di Poli Jiwa RSUD Sunan Kalijaga Demak pada bulan Maret-April 2025. Teknik sampling yang digunakan adalah purposive sampling dengan kriteria inklusi yaitu pasien terdiagnosis gangguan jiwa, berusia >15 tahun, dan pasien atau keluarga pasien yang bersedia menjadi responden serta bersedia mengisi kuesioner. Analisis data dilakukan secara univariat dan bivariat dengan menggunakan uji statistik Chi-Square. Diperoleh subyek penelitian sejumlah 100 pasien dengan diagnosis skizofrenia (91%), depresi (8%) dan bipolar (1%). Kualitas hidup pasien menunjukkan hasil yang tinggi pada dimensi kemampuan berjalan, perawatan diri, dan kegiatan yang biasa dilakukan serta hasil yang rendah pada dimensi rasa nyeri dan rasa cemas. Mayoritas pasien (55%) memiliki kualitas hidup yang rendah dengan tingkat kekambuhan yang tinggi (54%). Status pernikahan menjadi faktor yang berpengaruh pada kualitas hidup pasien. Hubungan kualitas hidup dan tingkat kekambuhan diperoleh nilai p value = 0,000. Terdapat hubungan yang signifikan antara kualitas hidup dan tingkat kekambuhan pasien gangguan jiwa.
ANALISIS BIAYA COST-EFFECTIVINESS ANTARA OBAT OMEPRAZOL DAN RANITIDIN PADA PASIEN GASTRITIS RAWAT INAP DI RS AISYIYAH KUDUS TAHUN 2024 Fairus, Mustika; Muslim, Ahmad Suriyadi; Rosnarita, Intan Adevia
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49313

Abstract

Gastritis adalah peradangan pada mukosa lambung yang bersifat akut, kronis, difus, atau lokal, ditandai dengan anoreksia, kembung, mual, muntah, dan rasa tidak nyaman pada ulu hati atau perut bagian atas. Peradangan pada dinding lambung merupakan penyebab terjadinya gastritis. Pemilihan terapi yang tepat dan efektivitas biayanya sangat penting untuk meningkatkan mutu pelayanan kesehatan. Penelitian ini bertujuan untuk menganalisis biaya berdasarkan efektivitas biaya omeprazol dan ranitidin pada pasien gastritis yang dirawat inap di Rumah Sakit Aisyiyah Kudus tahun 2024. Penelitian ini menggunakan metode analisis efektivitas biaya untuk membandingkan biaya dan efektivitas kedua obat tersebut. Hasil penelitian diperoleh data karakteristik pasien gastritis sebagian besar merupakan lansia akhir dengan rentang usia 56-65 tahun yaitu berjumlah 15 pasien dengan persentase 36,6%. Berdasarkan jenis kelamin, perempuan lebih banyak menderita gastritis yaitu sebanyak 22 pasien (53,7%), sedangkan pasien laki-laki menderita gastritis sebanyak 19 pasien (46,3%). Berdasarkan penelitian, hasil penelitian menunjukkan bahwa terapi pengobatan yang paling umum digunakan adalah omeprazol sebanyak 23 pasien (56,1%), sedangkan ranitidin sebanyak 18 pasien (43,9%). Rata-rata lama pengobatan pasien yang menggunakan omeprazol adalah 3,3 hari, sedangkan pasien yang menggunakan ranitidin selama 3,1 hari. Nilai ACER (Average Cost Effectiveness Ratio) untuk terapi omeprazol adalah Rp. 1.045.399, sedangkan nilai ACER untuk terapi ranitidin adalah Rp. 1.016.255. Berdasarkan analisis efektivitas biaya (CEA) antara omeprazol dan ranitidin, dapat disimpulkan bahwa ranitidin lebih efektif biaya dibandingkan terapi omeprazol.
FORMULASI MASKER GEL LIDAH BUAYA (Aloe Vera) UNTUK PENGENDALIAN BAKTERI Propionibacterium acnes Irvan Shahrul Hidayat; Muhammad Nurul Fadel; Intan Adevia Rosnarita
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1662

Abstract

Acne (Acne vulgaris) is a common skin problem, especially among adolescents, with a prevalence reaching 80-85% in Indonesia. One of the main causes of acne is the bacteria Propionibacterium acnes. Acne treatment usually uses synthetic antibiotics, but long-term use can cause side effects and bacterial resistance. Alternative natural treatments are needed to address this problem. Aloe vera is known to have antibacterial, anti-inflammatory, and cell regeneration-accelerating properties, making it potentially useful in skin care products. The active ingredients of aloe vera, such as anthraquinones, saponins, and flavonoids, are effective in inhibiting the growth of Propionibacterium acnes. Peel-off gel masks were chosen as topical preparations because they are practical, have a cooling effect, and can increase the penetration of active ingredients. This study aims to develop a gel mask formulation with aloe vera extract and test its effectiveness in inhibiting the growth of Propionibacterium acnes bacteria. This study used a laboratory experimental method with a post-test only control group design. The formulas used included various concentrations of aloe vera extract (5%, 10%, and 15%) and a positive control using 1% clindamycin. Evaluation of the preparations included organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and antibacterial activity testing using the disc diffusion method. Antibacterial effectiveness testing was divided into 5 treatment groups. The inhibition zone test against Propionibacterium acnes was conducted to assess the effectiveness of each formulation. The test data were analyzed using the One Way ANOVA statistical method with SPSS 25 software to determine significant differences between groups. Antibacterial testing was conducted by disc diffusion. The results of the study on the aloe vera extract peel-off gel mask formulation showed good organoleptic physical quality, homogeneity, adhesiveness, and drying time of the preparation, while the viscosity and spreadability tests did not meet the requirements, and the pH test on formula F3 did not meet the pH requirements for mouthwash preparations. In the antibacterial activity test of the peel-off gel mask preparation, the inhibition zone values ​​were obtained at F0 2.23 mm; F1 4.8 mm; F2 6 mm; F3 7.2 mm; and the positive control 33.5 mm.
Efektivitas Penggunaan Ringer Laktat Vs Ringer Asetat terhadap Durasi Rawat Inap Pasien Demam Berdarah Dengue Erwin Ari Pratiwi; Eko Retnowati; Intan Adevia Rosnarita
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7462

Abstract

Dengue hemorrhagic fever (DHF) is an endemic disease with high prevalence in Indonesia, particularly during the rainy season, when incidence rates significantly increase. One of the main treatments is supportive therapy through intravenous fluid administration to prevent shock and aid recovery. Ringer’s lactate and Ringer’s acetate are commonly used crystalloid fluids that differ in electrolyte composition and metabolic pathways in the body. This study aimed to compare the effectiveness of Ringer’s lactate and Ringer’s acetate in relation to the length of hospital stay among DHF patients. This research employed a retrospective analytic observational design, using data from medical records of 154 inpatients at RSUD dr. R. Soetrasno Rembang in 2024. Data analysis included normality testing and independent t-tests. The average length of hospitalization in the Ringer’s lactate group was 4.35 ± 1.121 days, while in the Ringer’s acetate group it was 4.06 ± 1.185 days. Although there was a difference in mean values, statistical analysis showed no significant difference between the two groups (p = 0.131). No significant differences were also found in laboratory parameters (platelets, leukocytes, hemoglobin, hematocrit) or body temperature. Based on these findings, it can be concluded that both types of fluids are equally effective as supportive therapy for DHF patients. Fluid selection may be adjusted according to the patient’s clinical condition, availability, and cost considerations.
PERBANDINGAN EFEKTIVITAS CEFOTAXIME DAN CEFTRIAXONE PADA PASIEN RAWAT INAP PEDIATRI DENGAN PNEUMONIA Rosnarita, Intan Adevia; Akhyasin, Akhtyasin; Dewi, Sintia Kusuma
IJF (Indonesia Jurnal Farmasi) Vol 9, No 1 (2024): IJF (Indonesia Jurnal Farmasi)
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v9i1.2425

Abstract

The prevalence of pneumonia for pediatrics in Indonesia is quite high. This condition is a concern for clinicians, especially pharmacists in handling the treatment of pneumonia in pediatrics. Treatment of pneumonia for pediatrics needs antibiotic therapy such as cefotaxime and ceftriaxone. This study aims to compare the effectiveness of the use of antibiotics cefotaxime and ceftriaxone in pediatric pneumonia patients at the inpatient installation of RSI Sunan Kudus Period February-April 2021. This study is a non-experimental research study with an observational analytic character, with purposive sampling, statistical analysis was carried out To compare the effectiveness of using cefotaxime and ceftriaxone based on duration of use and clinical symptoms, SPSS was performed using Paired T-Test. Based on the average duration of use for antibiotics cefotaxime 5 days and ceftriaxone 4.41 days. There was no difference in the average use of cefotaxime and ceftriaxone based on clinical symptoms such as cough, retractions, fever, shortness of breath and sore throat. The results of statistical analysis showed that ceftriaxone was more effective than cefotaxime in pediatric pneumonia, while there was no significant difference between ceftriaxone and cefotaxime (α) 0.05. The use of ceftriaxone is more effective in treating pediatric pneumonia than cefotaxime.
Co-Authors Ahmad Suriyadi Muslim Akhyasin, Akhtyasin Alfarizi, Nauval AMALIA, SHOFIA Apriliasari, Fiona Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Dewi, Sintia Kusuma Eko Retnowati Emma Jayanti Besan Erwin Ari Pratiwi Etikasari, Ria Fairus, Mustika Farni Yuliana Pratiwi Farni Yuliana Pratiwi Galih Kurniawan Hadiatussalamah Hadiatussalamah Hasriyani Irvan Shahrul Hidayat Muhamad Khudzaifi Muhammad Nurul Fadel Nanang Munif Yasin Novia Ariani Dewi Novia Ariani Dewi Priswa, Nindya Rengganis, Mutiara Riana Putri Rahmawati Yuda Anzas Mara Yuda Anzas Mara Yuliasari, Aulia Wahyu Zaimatuddunia, Irma