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All Journal Jurnal Biologi Tropis
Nensy Dwi Astika
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Type 2 Diabetes Mellitus and Early-Onset Colorectal Cancer: Mechanisms and Herbal Prevention Potential Wibisono Hasanul Muhtaram; Mira Nupila Rahma; Ashila Sallama Nur Fadlila; Indri Tiffani; Lalu Abdul Mubarak; Retno Dwi Utami; Baiq Mayada Isqie; Florentcia Davina Gunawan; Made Prajnana Adhi Parasikan Susana; Nensy Dwi Astika; Pande Komang Inten Widya Iswara Oka; Kurniati Kurniati
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.11899

Abstract

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related mortality worldwide. The incidence of early-onset colorectal cancer has continued to increase, and type 2 diabetes mellitus (T2DM), particularly chronic hyperglycemia, has been proposed as one of its contributing risk factors. This study aimed to evaluate the potential of herbal compounds as complementary approaches targeting molecular pathways linking T2DM and colorectal cancer. A systematic literature review was conducted following the PRISMA guidelines using PubMed and ScienceDirect. Original articles published between 2021 and 2026, written in English, available in full text, and investigating single herbal compounds or plant extracts in colorectal cancer models were included. The reviewed studies demonstrated that several herbal compounds, including glycyrrhizin, freeze-dried jaboticaba peel, Osmanthus fragrans extract, Ganoderma lucidum polysaccharide, Corallocarpus glomeruliflorus extract, galangin, dictamnine, silymarin, Portulaca oleracea extract, and curcumin, modulated key molecular pathways involved in colorectal carcinogenesis, particularly NF-κB, MAPK, Wnt/β-catenin, and YAP/TAZ signaling. Although these preclinical findings suggest potential complementary roles for herbal bioactive compounds in colorectal cancer prevention, further translational studies and well-designed clinical trials are required to confirm their efficacy and safety in individuals with T2DM.
The Relationship Between Insomnia and Suicidal Behavior in Adolescents at SMAN 11 Mataram Nensy Dwi Astika; I Putu Diatmika; Lale Justin Amelinda Elizar; Arfi Syamsun
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12264

Abstract

Adolescence is a vulnerable period for mental health problems, including suicidal behavior. Insomnia is frequently experienced by adolescents and may be associated with emotional dysregulation and psychological distress. This intention of this study was to analyze relationship between insomnia and suicidal behavior among adolescents at SMAN 11 Mataram. This analytical observational study used a cross-sectional design involving 89 students of SMAN 11 Mataram. The sample size was determined using the Slovin from a population of 113 students with a 5% margin of error. Sampling was conducted using stratified random sampling based on grade level: grade 10(29 students), grade 11(36 students), and grade 12(48 students), with proportional random selection resulting in 23, 28, and 37 students, respectively. Data were collected using the validated Indonesian version of the Insomnia Severity Index (ISI) and Suicide Behaviors Questionnaire-Revised (SBQ-R). Insomnia was categorized based on ISI score ≥10, while suicidal behavior risk was identified using SBQ-R score ≥7. Reliability analysis showed Cronbach’s alpha values of 0.750 for ISI and 0.896 for SBQ-R.Spearman’s rank correlation test showed a significant association between insomnia and suicidal behavior (r = 0.229; p = 0.031). It was concluded there is a positive association between insomnia and suicidal with a weak correlation.    
Necrotizing Erythema Nodosum Leprosum (ENL) Post-MDT in Multibacillary Hansen’s Disease: A Case Report Mira Nupila Rahma; Made Prajnana Adhi Parasikan Susana; Wibisono Hasanul Muhtaram; Ashila Sallama Nur Fadlila; Indri Tiffani; Lalu Abdul Mubarak; Retno Dwi Utami; Baiq Mayada Isqie; Florentcia Davina Gunawan; Nensy Dwi Astika; Pande Komang Inten Widya Iswara Oka; Kurniati Kurniati; Yunita Hapsari
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12326

Abstract

Necrotic erythema nodosum leprosum (ENL) is a rare and severe type 2 leprosy reaction that mainly affects patients with multibacillary Hansen's disease and may progress to tissue necrosis. We report the case of a 26-year-old woman with released-from-treatment (RFT) multibacillary Hansen's disease who presented with recurrent painful erythematous nodules, cutaneous necrosis, paresthesia, numbness, and peripheral neuropathy. Clinical examination revealed enlarged and tender peripheral nerves with sensory and motor impairment, while slit-skin smear demonstrated a bacteriological index of +3. Laboratory findings showed leukocytosis, neutrophilia, and mild microcytic anemia, indicating an active inflammatory process. The patient was diagnosed with recurrent necrotic ENL after completion of multidrug therapy and was treated with systemic corticosteroids, analgesics, wound care, emollients, neurotropic supplementation, and iron therapy. Clinical improvement and a reduction in the bacteriological index were observed during follow-up, although recurrent skin lesions and residual sensory neuropathy persisted. This case emphasizes that necrotic ENL may occur after RFT and highlights the importance of early recognition, appropriate treatment, and close follow-up to reduce recurrence, prevent irreversible nerve damage, and improve long-term outcomes.
Co-Authors Arfi Syamsun Ashila Sallama Nur Fadlila Baiq Mayada Isqie Florentcia Davina Gunawan I Putu Diatmika Indri Tiffani Kurniati Kurniati Lale Justin Amelinda Elizar Lalu Abdul Mubarak Made Prajnana Adhi Parasikan Susana Mira Nupila Rahma Pande Komang Inten Widya Iswara Oka Retno Dwi Utami Wibisono Hasanul Muhtaram Yunita Hapsari