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All Journal Jurnal Abdi Masyarakat Multidisiplin Journal of Pharmaceutical and Sciences.
Muzakkir Muzakkir
Universitas Tjut Nyak Dhien
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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 1 
Efek Dosis–Respons Ekstrak Etanol Daun Cayratia trifolia Linn. pada Edema Kaki Tikus Terinduksi Karagenan Muzakkir Muzakkir; Bunga Rimta Barus; Meutia Indriana; Salman Salman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1798

Abstract

Introduction: Leaves of Cayratia trifolia Linn. contain several secondary metabolites with potential anti-inflammatory activity. However, evidence regarding the dose–response relationship of their ethanolic extract in acute inflammation remains limited. Objective: To evaluate the anti-inflammatory activity and dose–response trend of Cayratia trifolia leaf ethanolic extract (CTLEE) in a carrageenan-induced rat paw edema model. Methods: Twenty-five male rats (Rattus norvegicus) were divided into five groups (n=5): a 0.5% Na-CMC negative control, a 0.2% diclofenac sodium positive control, and CTLEE treatment groups receiving 100, 200, or 300 mg/kg body weight. Treatments were administered orally, followed 30 min later by an intraplantar injection of 0.1 mL of 1% carrageenan. Paw volume was measured every 60 min for 360 min using a digital plethysmometer. Data were expressed as mean ± SD and analyzed using one-way ANOVA followed by Tukey's post hoc test (p<0.05p<0.05p<0.05). Results: CTLEE reduced paw oedema relative to the negative control and showed a trend toward greater activity as the dose increased. At 360 min, edema percentages were 38.25 ± 11.88%, 29.21 ± 5.36%, and 24.43 ± 6.60% for CTLEE at 100, 200, and 300 mg/kg, respectively, compared with 74.83 ± 13.77% in the negative-control group. The corresponding inhibition values were 48.74 ± 12.10%, 60.24 ± 8.57%, and 65.43 ± 13.96%. Significant differences in paw edema were observed among groups at all assessment times (p<0.001p<0.001p<0.001). Conclusion: CTLEE demonstrated anti-inflammatory activity with a dose-related trend. The 300 mg/kg dose produced the greatest edema reduction and inhibition among the tested extract doses; however, therapeutic equivalence with diclofenac sodium was not established.
Formulasi dan Evaluasi Gel Pengharum Serai Wangi dengan Kombinasi Basis Karagenan, Xanthan Gum, dan HPMC Windi Anggraini; Salman Salman; Yessi Febriani; Meutia Indriana; Muzakkir Muzakkir
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1459

Abstract

Background: Unpleasant odors in bathroom areas are a common hygiene problem that requires practical and environmentally friendly solutions. Citronella oil (Cymbopogon nardus L. Randle) is known to contain active compounds with a distinctive aroma that has potential as a natural fragrance agent. However, an appropriate gel base is needed to maintain the stability and aroma retention of the preparation. Objective: This study aims to formulate and evaluate a bathroom fragrance gel from citronella oil with a combination of carrageenan, xanthan gum, and hydroxypropyl methylcellulose (HPMC) bases and to determine the concentration of citronella oil that produces the preparation with the best physical stability and aroma retention. Methods: This research was an experimental laboratory study. Citronella oil was formulated into gel preparations with four concentration variations (2.5%; 5%; 7.5%; and 10%) using a combination of carrageenan, xanthan gum, and HPMC bases. Evaluation of the preparations included organoleptic test, syneresis, liquid evaporation, preference test (hedonic), and aroma retention test for 15 days of storage. Data were analyzed statistically with a 95% confidence level. Results: The results showed that all formulas produced gels with good organoleptic characteristics (cloudy white color, characteristic citronella aroma, and semi-solid texture). The formula with 10% citronella oil concentration (F4) showed the best results with the lowest syneresis value (0.62%), the lowest liquid evaporation percentage (21.69%), and the highest remaining gel weight (92.03%). The preference test showed that F4 had the highest average value (4.25) in the like category, and the best aroma retention with a score range of 4.19-4.70 until day 15. Conclusion: The combination of carrageenan, xanthan gum, and HPMC bases can produce physically stable bathroom fragrance gel preparations. The formula with 10% citronella oil concentration (F4) is the best formulation and has the most potential to be developed as a natural bathroom fragrance product.
Edukasi Penggunaan Obat Aman dan Rasional Berbasis Kimia Farmasi pada Siswa SMA Negeri 2 Binjai Rahma Yulia; Dea Anggraini; Muzakkir Muzakkir; Salman salman; Meutia Indriana; Desy Natalia Siahaan; Bunga Rimtam Barus
 Jurnal Abdi Masyarakat Multidisiplin Vol. 5 No. 01 (2026): April: JURNAL ABDI MASYARAKAT MULTIDISIPLIN
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jammu.v5i01.2977

Abstract

Kemudahan akses informasi obat melalui media sosial, iklan, keluarga, dan sumber digital perlu diimbangi dengan literasi obat yang memadai agar remaja mampu menggunakan obat secara aman dan rasional. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan edukasi awal mengenai penggunaan obat yang aman dan rasional, membiasakan siswa memperhatikan informasi dan aturan penggunaan obat, mengenalkan risiko penggunaan obat yang tidak tepat, serta mendorong sikap selektif terhadap sumber informasi obat. Kegiatan dilaksanakan pada 14 Oktober 2025 di SMA Negeri 2 Binjai dengan melibatkan 35 siswa. Metode yang digunakan berupa edukasi dengan pendekatan deskriptif-kualitatif melalui penyampaian materi, diskusi, tanya jawab, observasi keterlibatan peserta, dan dokumentasi. Materi meliputi pengenalan obat dan zat aktif, dosis dan aturan pakai, label dan tanggal kedaluwarsa, penyimpanan, efek samping, penggunaan obat rasional, serta swamedikasi bertanggung jawab. Pendekatan kimia farmasi diterapkan menggunakan contoh obat yang familiar, seperti parasetamol, aspirin, CTM, dan antasida, untuk memperkenalkan hubungan sederhana antara zat aktif, struktur kimia, manfaat, risiko, dan aturan penggunaan. Hasil kegiatan menunjukkan keterlibatan peserta melalui perhatian, partisipasi dalam diskusi, serta pertanyaan mengenai aturan pakai, keamanan, efek samping, dan karakteristik zat aktif. Kegiatan ini menunjukkan bahwa pendekatan kimia farmasi dapat digunakan sebagai konteks edukatif yang komunikatif untuk menyampaikan literasi penggunaan obat kepada siswa SMA. Namun, karena evaluasi masih bersifat deskriptif dan tidak menggunakan pre-test dan post-test, hasil kegiatan belum dapat menunjukkan perubahan pengetahuan peserta secara kuantitatif. Kegiatan selanjutnya disarankan menggunakan instrumen evaluasi terstruktur untuk mengukur perubahan pemahaman dan literasi obat secara objektif.
Co-Authors Bunga Rimta Barus Bunga Rimtam Barus Dea Anggraini Desy Natalia Siahaan Meutia Indriana Meutia Indriana Rahma Yulia Salman Salman Salman Salman Windi Anggraini Yessi Febriani