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All Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Jurnal Mahasiswa Ilmu Kesehatan
Haura Rasyikha Alhanin
Universitas Duta Bangsa Surakarta
Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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Potensi Antioksidan Ekstrak Buah Naga Merah (Hylocereus polyrhizus) sebagai Agen Preventif Inflamasi Gingiva: Kajian Literatur Anindya Rizqita Salsabila; Haura Rasyikha Alhanin; Fatika Puteri Rosyi Prabowo; Arin Oktaviani Suningdyastiningrum; Rahastuti
Jurnal Mahasiswa Ilmu Kesehatan Vol. 4 No. 2 (2026): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v4i2.3889

Abstract

Inflamasi gingiva merupakan kondisi periodontal yang dipengaruhi oleh akumulasi biofilm plak dan peningkatan stres oksidatif akibat produksi Reactive Oxygen Species (ROS) yang berlebihan. Antioksidan berpotensi menghambat kerusakan jaringan periodontal dengan menetralisasi radikal bebas. Buah naga merah (Hylocereus polyrhizus) mengandung flavonoid, polifenol, vitamin C, dan betasianin yang memiliki aktivitas antioksidan dan antiinflamasi, sehingga berpotensi sebagai agen preventif inflamasi gingiva. Tujuan: Mengkaji potensi ekstrak buah naga merah sebagai agen preventif inflamasi gingiva berdasarkan aktivitas antioksidan dan bukti ilmiah yang tersedia. Metode: Penelitian ini merupakan studi literatur dengan pencarian sistematis pada basis data PubMed, ScienceDirect, Scopus, dan Google Scholar menggunakan kata kunci terkait Hylocereus polyrhizus, antioksidan, aktivitas antiinflamasi, gingivitis, dan stres oksidatif. Artikel yang relevan dianalisis secara naratif berdasarkan kandungan senyawa bioaktif, aktivitas antioksidan, dan efek antiinflamasi. Hasil: Ekstrak buah naga merah mengandung senyawa bioaktif dengan aktivitas antioksidan. Beberapa penelitian menunjukkan bahwa ekstrak mampu menghambat denaturasi protein, menurunkan jumlah leukosit selama proses inflamasi, meningkatkan kapasitas antioksidan, serta berpotensi menekan mediator proinflamasi melalui penurunan stres oksidatif. Simpulan: Ekstrak buah naga merah berpotensi sebagai agen preventif inflamasi gingiva melalui mekanisme antioksidan dan antiinflamasi. Namun, uji klinis pada manusia masih diperlukan untuk memastikan efektivitas, keamanan, dosis optimal, dan formulasi yang tepat.
ORAL MICROBIOME RECOVERY FOLLOWING ANTIMICROBIAL EXPOSURE: A SCOPING REVIEW OF MICROBIAL RESILIENCE AND RESTORATION OF HOMEOSTASIS Kayza Cindy Aulia; Haura Rasyikha Alhanin; Keisya Daniyah Rahma; Fatika Puteri Rosyi Prabowo; Arin Oktaviani Suningdyastiningrum
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2026: Proceeding of the 7th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/7xw4sc83

Abstract

The oral microbiome is a dynamic microbial ecosystemthat can be disrupted by antimicrobial exposure, resultingin changes in microbial composition, diversity, andcommunity structure. The capacity of the oral microbiometo withstand environmental disturbances andsubsequently regain ecological stability represents animportant characteristic of microbial resilience and isclosely related to the maintenance of oral microbialhomeostasis. This scoping review aimed to map theavailable evidence regarding oral microbiome responsesfollowing antimicrobial exposure, with particularemphasis on microbial resilience, recovery, andrestoration of homeostasis. Literature was searchedthrough PubMed, ScienceDirect, and Google Scholar usingterms related to oral microbiome, antimicrobial exposure,microbial resilience, and microbial homeostasis. Relevantliterature published within the predefined period wasscreened according to predetermined inclusion andexclusion criteria, followed by data extraction anddescriptive evidence mapping. The findings indicate thatantimicrobial exposure may substantially modify oralmicrobial composition, diversity, community structure,and ecological interactions. Evidence from the includedstudies suggests that oral microbial communities possessvarying degrees of resilience following microbialdisturbance, with recovery influenced by the type andintensity of antimicrobial exposure, characteristics of themicrobial community, and host-related ecological factors.However, the extent and completeness of recovery towardthe pre-exposure state vary across microbialcommunities and exposure conditions. These findingshighlight the importance of understanding oralmicrobiome resilience and recovery as key processes in the restoration and maintenance of oral microbialhomeostasis and provide a basis for further longitudinalresearch on strategies to preserve microbial stabilityfollowing antimicrobial disturbance.
Co-Authors Anindya Rizqita Salsabila Arin Oktaviani Suningdyastiningrum Fatika Puteri Rosyi Prabowo Fatika Puteri Rosyi Prabowo Kayza Cindy Aulia Keisya Daniyah Rahma Rahastuti