<![CDATA[Highlights: Visceral adipose tissue demonstrated a positive and significant correlation with the LDL-C to HDL-C ratio, with the majority of participants exhibiting elevated VAT levels also showing high LDL-C to HDL-C ratios. An increase in BMI tended to correspond with a rise in the lipid ratio. Abstract Introduction: Cardiovascular diseases (CVDs) continue to be a leading cause of death worldwide. In Indonesia, factors contributing to CVDs, including obesity and abnormal lipid profiles, have been increasingly prevalent among adults. The low-density lipoprotein cholesterol (LDL-C)-to-high-density lipoprotein cholesterol (HDL-C) ratio is a well-established indicator used to assess the risk of CVD. This study examined how nutritional factors, particularly body mass index (BMI) and visceral adipose tissue (VAT), influence the LDL-C-to-HDL-C ratio in adults. Methods: This was a cross-sectional study comprising laboratory medical check-up results from employees of Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia. The bivariate analysis was conducted using logistic regression (significant at p<0.05). The data were analyzed statistically using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 27.0. Results: Among 56 participants (n=56), BMI was categorized as obese (48.2%), overweight (5.4%), and normal weight (46.4%), while VAT was categorized as high (69.6%), increased (21.4%), and normal level (8.9%). The analysis showed a positive but not significant association between BMI and the LDL-C-to-HDL-C ratio (Odds Ratio/OR=1.230; 95% Confidence Interval/CI=1.706-2.143; p=0.464). In contrast, there was a positive and significant relationship between VAT and the LDL-C-to-HDL-C ratio (OR=3.918; 95% CI=1.143-13.430; p=0.030). Conclusion: This study revealed a significant relationship between VAT and the LDL-C-to-HDL-C ratio, whereas no notable link was observed between BMI and the LDL-C-to-HDL-C ratio among the employees.]]>
