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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Biomedika dan Kesehatan Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga eJournal Kedokteran Indonesia
Tuty Rizkianti
Department Of Clinical Pathology, Faculty Of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia.
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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HUBUNGAN JUMLAH LEUKOSIT DENGAN MOTILITAS SPERMATOZOA PADA ANALISIS SEMEN PRIA DI SAMMARIE FAMILY HEALTHCARE 2019 Ayutama, Wanodia; Rizkianti, Tuty; Fauziah, Cut
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 4, No 2 (2020): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v4i2.7788

Abstract

Infertility is one of the most common male reproductive health problems. Male infertility is the inability of a male to result pregnancy in a fertile female in one year of non-contracepting sexual intercourse. Male with poor sperm quality are more susceptible to infertility. One of the cause of infertility in men is disruption of spermatozoa motility. Imperfect motility will reduce the quality of spermatozoa and the probability of conception. One cause of decreased motility is inflammation of the male reproductive tract. Inflammation that occurs will increase the recruitment of leukocytes in the reproductive tract and increase the production of reactive oxygen species (ROS) so it can interfere the process of sperm formation and maturation. The purpose of this study was to determine the relationship between leukocyte counts and spermatozoa motility. The number of leukocytes and the percentage of spermatozoa motility were obtained from semen analysis as secondary data. The research design used was cross-sectional. The number of samples in this study were 66 respondents who met the inclusion criteria.The results of the study showed a significant inverse relationship (negative correlation) (p = 0.007, r = -0.328) between the number of leukocytes and spermatozoa motility, which means  if the number of semen leukocytes increases, the percentage of spermatozoa motility will decrease. Keywords: inflammation; leukocyte counts; spermatozoa motility ABSTRAKInfertilitas merupakan salah satu masalah kesehatan reproduksi pria yang sering dijumpai. Infertilitas pada pria adalah ketidakmampuan seorang pria untuk menyebabkan kehamilan pada seorang wanita fertil setelah satu tahun hubungan seksual tanpa alat kontrasepsi. Pria dengan kualitas sperma yang kurang baik lebih rentan mengalami infertilitas. Salah satu penyebab infertilitas pada pria adalah gangguan pada motilitas spermatozoa. Motilitas yang kurang sempurna akan menyebabkan penurunan kualitas spermatozoa dan penurunan probabilitas terjadinya pembuahan. Salah satu penyebab penurunan motilitas adalah inflamasi pada saluran reproduksi pria. Inflamasi yang terjadi akan meningkatkan rekruitmen leukosit pada saluran  reproduksi pria dan meningkatkan produksi reactive oxygen species (ROS) yang bersifat toksik bagi spermatozoa sehingga dapat mengganggu proses pembentukan dan pematangan spermatozoa. Tujuan penelitian ini adalah untuk mengetahui hubungan antara jumlah leukosit dengan motilitas spermatozoa. Jumlah leukosit dan persentase motilitas spermatozoa didapatkan dari data sekunder, yaitu data hasil analisis semen. Desain penelitian yang digunakan adalah potong lintang (cross-sectional). Jumlah sampel dalam penelitian ini sebanyak 81 pasien yang memenuhi kriteria inklusi. Hasil dari penelitian menunjukkan terdapat hubungan terbalik (korelasi negatif) yang bermakna dengan kekuatan korelasi sangat lemah (p = 0.007, r = -0.328) antara jumlah leukosit dengan motilitas spermatozoa, yang berarti jika jumlah leukosit semen semakin meningkat, maka persentase motilitas spermatozoa akan semakin rendah.
PERBANDINGAN PROFIL GLUKOSA DARAH PASIEN STROKE ISKEMIK DAN STROKE HEMORAGIK DI RSUP FATMAWATI TAHUN 2018 Husna, Intan Rahma; Astari, Riezky Valentina; Rizkianti, Tuty
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 5, No 1 (2021): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v5i1.8217

Abstract

Stroke is the death of brain cells due to lack of blood flow and oxygen to the brain by blockage or rupture of an artery. Stress hyperglycemia in acute stroke may worsen the clinical outcome and the prognosis of stroke. The purpose of this study is to find out and compare blood glucose profile between ischemic stroke and hemorrhagic stroke. This is an observational analytic cross-sectional research using consecutive sampling. Data was obtained through medical record from January to December 2018 in RSUP Fatmawati with each group of stroke consisting of 74 samples. Data was processed using SPSS 2017. Mann-Whitney test shows a significant difference in random blood glucose levels between ischemic stroke and hemorrhagic stroke (p = 0.024), with the median value of random blood glucose level during ischemic stroke is 115.50 mg / dL and hemorrhagic stroke is 136.50 mg / dL. The results also shows a significant difference in fasting blood glucose levels between ischemic stroke and hemorrhagic stroke (p = 0.042), with the median value of fasting blood glucose level for ischemic stroke is 116.50 mg / dL and hemorrhagic stroke is 125.50 mg / dL. A significant difference is also seen in 2 hours post-prandial glucose level between ischemic stroke and hemorrhagic stroke (p = 0.028), with the median value of 2 hours post-prandial glucose level of  ischemic stroke is 130 mg / dL and hemorrhagic stroke is 147.50 mg / dL. Keywords: Ischemic Stroke; Hemorrhagic Stroke; Random Blood Glucose; Fasting Blood Glucose; 2 Hour Post-Prandial Blood Glucose AbstrakStroke adalah kematian sel-sel otak akibat hilangnya pasokan darah dan oksigen ke otak karena adanya  hambatan atau ruptur arteri yang menuju otak. Pada stroke fase akut dapat terjadi hiperglikemia reaktif yang dapat memperburuk  keluaran klinis dan prognosis stroke. Penelitian ini dilakukan untuk mengetahui dan membandingkan profil glukosa darah antara stroke iskemik dan stroke hemoragik. Penelitian ini bersifat analitik observasional dengan desain potong lintang dan pemilihan sampel consecutive sampling. Data didapat dari rekam medis periode Januari-Desember 2018 di RSUP Fatmawati dengan masing-masing kelompok stroke sebanyak 74 sampel. Pengolahan data dilakukan dengan program SPSS tahun 2017. Uji Mann-Whitney menunjukkan adanya perbedaan bermakna kadar Glukosa Darah Sewaktu antara stroke iskemik dengan stroke hemoragik (p = 0,024), dengan nilai median Glukosa Darah Sewaktu stroke iskemik adalah 115,50 mg/dL dan stroke hemoragik adalah 136,50 mg/dL. Hasil juga menunjukkan adanya perbedaan bermakna kadar Glukosa Darah Puasa antara stroke iskemik dan stroke hemoragik (p = 0,042), dengan nilai median Glukosa Darah Puasa stroke iskemik adalah 116,50 mg/dL dan stroke hemoragik adalah 125,50 mg/dL, serta adanya perbedaan bermakna kadar Glukosa Darah 2 Jam Post-Prandial antara stroke iskemik dan stroke hemoragik (p = 0,028), dengan nilai median Glukosa Darah 2 Jam Post-Prandial stroke iskemik adalah 130 mg/dL dan stroke hemoragik adalah 147,50 mg/dL.
Pengaruh Pemberian Ekstrak Plumeria Rubra terhadap Fungsi Ginjal Tikus Model Hiperurisemia Nahdah Aidah; Muttia Amalia; Tuty Rizkianti
eJournal Kedokteran Indonesia Vol 9, No. 2 - Agustus 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.439 KB) | DOI: 10.23886/ejki.9.27.105

Abstract

Kadar asam urat tinggi dapat meningkatkan stres oksidatif di ginjal yang menyebabkan kerusakan glomerulus dan iskemia tubular. Ekstrak bunga kamboja (Plumeria rubra) mengandung kadar flavonoid tinggi yang dapat mencegah stres oksidatif dan menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak P. rubra terhadap fungsi ginjal pada tikus model hiperurisemia. Penelitian dilakukan pada bulan Februari – Maret 2020 di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjajaran Bandung. Desain penelitian adalah eksperimental menggunakan tikus Rattus novergicus sebanyak 30 ekor yang dibagi dalam 5 kelompok dengan 6 tikus pada masing-masing kelompok. Kelompok kontrol terdiri atas kelompok 1 (kontrol negatif) dan kelompok 2 (kontrol positif dengan alopurinol ), kelompok 3, 4 dan 5 yang masing-masing mendapatkan dosis ekstrak P. rubra 200, 400 dan 600 mg/KgBB/hari. Penelitian dilakukan selama 14 hari dengan intervensi pada minggu pertama berupa induksi dan seminggu selanjutnya perlakuan. Sampel darah diambil melalui ekor tikus untuk menilai kadar asam urat dan kreatinin. Data dianalisis dengan uji Kruskall-Wallis. Hasil yang berbeda bermakna terdapat pada dosis 200, 400 dan 600 mg terhadap kadar asam urat (nilai p=0,004, 0,008 dan 0,004) sedangkan pada kreatinin perbedaan bermakna terdapat pada dosis 200 dan 400 mg (nilai p=0,004 dan 0,042). Terdapat penurunan signifikan pada kadar kreatinin setelah pemberian ekstrak P. rubra 400 mg/KgBB/hari yang berarti dapat memperbaiki fungsi ginjal tikus hiperurisemia. Kata kunci: fungsi ginjal, P. rubra, hiperurisemia, potasium oksonat dan antioksidan.   The Effect of Plumeria rubra Extract on Kidney Function in Hyperuricemic Rat Model Abstract Hyperuricemia can increase oxidative stress in kidney which will cause glomerular damage and tubular ischemia. Frangipani flower extract (Plumeria rubra) contains high amounts of phenols and flavonoids which can prevent the formation of oxidative stress and can reduce uric acid levels. This study aims to determine the effect of frangipani flower extract on kidney function in white rats induced by potassium oxonate. This research was conducted in February – March 2020 at the laboratory of pharmacology and therapy, faculty of medicine, Universitas Padjajaran, Bandung. The design of this study was experimental using 30 Rattus novergicus rats divided into 5 groups with 6 mice in each group. The control group consisted of group 1 (negative control) and group 2 (positive control with alopurinol ). The treatment group consisted of groups 3, 4, and 5, which were variations in doses of P. rubra extract 200, 400, and 600 mg/KgBB /day. The study was conducted for 14 days with the first week of induction and a week later of treatment. Blood samples are taken through the tail to assess uric acid and creatinine levels. The study was analyzed using Kruskall-Wallis. The results of significant differences were found at doses of 200, 400 and 600 mg of uric acid levels (p-value 0.004, 0.008 and 0.004) while the mean creatinine differences were found at doses of 200 and 400 mg (p-values 0.004 and 0.042). In this study, a significant decrease in creatinine levels after treatment showed that there was an effect of P. rubra extract on kidney function with an effective dose of 400 mg/kg/day. Keywords: kidney function, P. rubra, hyperuricemia, potassium oxonate and antioxidants.
Perubahan Antropometri dan Hemoglobin setelah Edukasi Gizi dan PMT pada Balita Malnutrisi Nugrahayu Widyawardani; Nurfitri Bustamam; Taufiq Fredrik Pasiak; Tuty Rizkianti; Citra Ayu Aprilia; Panji Octo Prasetio; Nevanya Rosaria Angelita; Fasya Fadhilah Agustin Mulyadi
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.141-150

Abstract

Background Malnutrition among children under five remains a major public health concern, including in semi-urban areas such as Klapanunggal, Bogor. Inadequate dietary intake may contribute to underweight, wasting, low hemoglobin concentration, and anemia. This study evaluated changes in maternal nutrition knowledge, child anthropometric indicators, and hemoglobin concentration following nutrition education and local food-based supplementary feeding. Methods A one-group pre–post intervention study involved 37 children aged 6–59 months with underweight or wasting. Mothers received nutrition education, while children received local food-based supplementary feeding for 28 days in the underweight group and 56 days in the wasting group. Data were collected using structured questionnaires, two non-consecutive 24-hour dietary recalls, anthropometric measurements, and capillary hemoglobin testing. Normality of paired differences was assessed using the Shapiro–Wilk test. Paired-samples t-tests were used for normally distributed data, while Wilcoxon signed-rank tests were used for non-normally distributed data. Results Maternal nutrition knowledge, weight-for-height z-scores, weight-for-age z-scores, and hemoglobin concentration increased significantly after the intervention. However, information on concurrent iron supplementation, infection treatment, and other clinical interventions was not systematically recorded. Conclusions Nutrition education and local food-based supplementary feeding were associated with improved maternal nutrition knowledge and child anthropometric indicators. The increase in hemoglobin concentration should be interpreted cautiously because potential concurrent supplementation and clinical treatment were not documented or controlled.
Glycemic Status And Its Associated Risk Factors Among Hospitalized Indonesian Hajj Pilgrims With Type 2 Diabetes Mellitus In Saudi Arabia Muniroh; Syifa Laila Nazmi; Dwi Tyastuti; Tuty Rizkianti; Adib Achmad
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 20 No 1 (2026): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v20i1.12511

Abstract

Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease among Indonesian Hajj pilgrims, particularly in older adults. The strenuous physical activities and environmental stress during the pilgrimage may exacerbate glycemic instability and increase metabolic complications. This study aimed to analyze random blood glucose (RBG) levels and their association with age, gender, and number of comorbidities among hospitalized Indonesian Hajj pilgrims with T2DM in Saudi Arabia in 2023. A descriptive-analytic cross-sectional design was applied using secondary data from the Integrated Hajj Health Information System (Siskohatkes). A total of 292 hospitalized Indonesian Hajj pilgrims diagnosed with T2DM (ICD-10 E11) and available RBG results were included. Chi-square analysis with a significance level of p≤0.05 was used. Most participants were aged ≥60 years (75.3%), male (54.8%), and had fewer than two comorbidities (57.2%). Uncontrolled RBG levels (≥200 mg/dL) were found in 58.9% of participants. While gender and comorbidities were not significantly associated with glycemic control, age showed a near-significant relationship (p=0.050). These findings highlight the need for targeted pre-departure screening and enhanced diabetes management for elderly Hajj pilgrims to prevent complications during the pilgrimage.
Body Mass Index and Visceral Adipose Tissue in Relation to Low-Density Lipoprotein to High-Density Lipoprotein Ratio among Adults Bungahati Kita; Marlina Dewiastuti; Melly Kristanti; Mila Citrawati; Tuty Rizkianti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 2 (2026): IN-PROGRESS ISSUE (AUGUST 2026)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I22026.126-131

Abstract

Highlights: Visceral adipose tissue demonstrated a positive and significant correlation with the LDL-C to HDL-C ratio, with the majority of participants exhibiting elevated VAT levels also showing high LDL-C to HDL-C ratios. An increase in BMI tended to correspond with a rise in the lipid ratio.   Abstract Introduction: Cardiovascular diseases (CVDs) continue to be a leading cause of death worldwide. In Indonesia, factors contributing to CVDs, including obesity and abnormal lipid profiles, have been increasingly prevalent among adults. The low-density lipoprotein cholesterol (LDL-C)-to-high-density lipoprotein cholesterol (HDL-C) ratio is a well-established indicator used to assess the risk of CVD. This study examined how nutritional factors, particularly body mass index (BMI) and visceral adipose tissue (VAT), influence the LDL-C-to-HDL-C ratio in adults. Methods: This was a cross-sectional study comprising laboratory medical check-up results from employees of Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia. The bivariate analysis was conducted using logistic regression (significant at p<0.05). The data were analyzed statistically using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 27.0. Results: Among 56 participants (n=56), BMI was categorized as obese (48.2%), overweight (5.4%), and normal weight (46.4%), while VAT was categorized as high (69.6%), increased (21.4%), and normal level (8.9%). The analysis showed a positive but not significant association between BMI and the LDL-C-to-HDL-C ratio (Odds Ratio/OR=1.230; 95% Confidence Interval/CI=1.706-2.143; p=0.464). In contrast, there was a positive and significant relationship between VAT and the LDL-C-to-HDL-C ratio (OR=3.918; 95% CI=1.143-13.430; p=0.030). Conclusion: This study revealed a significant relationship between VAT and the LDL-C-to-HDL-C ratio, whereas no notable link was observed between BMI and the LDL-C-to-HDL-C ratio among the employees.
Co-Authors Adib Achmad Astari, Riezky Valentina Ayutama, Wanodia Bungahati Kita Citra Ayu Aprilia Cut Fauziah Dwi Tyastuti Fasya Fadhilah Agustin Mulyadi Husna, Intan Rahma Marlina Dewiastuti Melly Kristanti Mila Citrawati Muniroh Muttia Amalia Nahdah Aidah Nevanya Rosaria Angelita Nugrahayu Widyawardani Nurfitri Bustamam Panji Octo Prasetio Syifa Laila Nazmi Taufiq Fredrik Pasiak