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All Journal VALENSI Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Chemistry Indonesian Journal of Chemical Research Jurnal Onoma: Pendidikan, Bahasa, dan Sastra e-Journal of ELTS (English Language Teaching Society)
Firdayani, Firdayani
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Biochemistry, Genetics & Molecular Biology Chemistry Education Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology

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Synthesis and Cytotoxic Evaluation of 3-Dimethyl Carbamoyl Emodin Firdayani, Firdayani; Listiana, Shelvi; Witanto, Billy
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 2, November 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i2.34654

Abstract

Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a natural anthraquinone derivative with potential pharmacological such as cytotoxic effects. The structure modification could be performed to determine the functional groups that have the role of substance activities. In this study, we modified one hydroxy group in the emodin structure to become dimethyl carbamoyl moiety. Emodin was reacted with dimethyl carbamoyl chloride and potassium carbonate to create 3-dimethyl carbamoyl emodin. The structure of the product was elucidated using mass spectrophotometer (MS), Fourier transform infrared (FTIR), proton and carbon nuclear magnetic resonance (H-NMR and C-NMR). These substances were tested for cytotoxicity against HepG2 cell lines using the MTT assay. According to the evaluation, 3-dimethyl carbamoyl emodin is less cytotoxic than emodin. As a result, the hydroxy group at the C3 position of emodin has been identified as a functional component that contributes to its cytotoxic effect.
Screening Emodin Derivatives as DPP-4 Inhibitor Candidates: In Silico and In Vitro Assessment Azkiyah, Dina; Syahbirin, Gustini; Firdayani, Firdayani; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-din

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease distinguished by disrupted glucose metabolism, causing elevated blood sugar levels. One of the latest therapeutic strategies involves inhibiting dipeptidyl peptidase-4 (DPP-4) to regulate glucose metabolism. Emodin, a bioactive compound, has shown potential as a DPP-4 inhibitor, but its efficacy requires further research. This study aims to identify and assess emodin and its derivatives as potential DPP-4 inhibitors through a comprehensive in silico and in vitro analysis. Molecular docking analysis revealed that 3-ρ-toluoyl emodin (ρTE) had the lowest binding energy (-111.4 kcal/mol) among the tested compounds. Furthermore, in vitro testing showed consistent results in silico, indicating that ρTE had significant inhibitory activity with an IC50 value of 1.37 μM. Pharmacokinetic and physicochemical evaluations confirmed ρTE’s potential as a safe antidiabetic drug candidate. The research findings indicate that ρTE holds potential as a promising drug candidate for further development.
THE USE OF DEMONSTRATION TECHNIQUE TO IMPROVE WRITING SKILL OF THE ELEVENTH GRADE STUDENTS Firdayani, Firdayani; Nadrun, Nadrun; Rofiqoh, Rofiqoh; Maf'ulah, Maf’ulah
e-Journal of ELTS (English Language Teaching Society) Vol. 13 No. 2 (2025)
Publisher : Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/elts.v13i2.4631

Abstract

The objective of this research is to prove whether the application of demonstration technique can improve writing skills of the eleventh-grade students of SMA Negeri 1 Witaponda or not. The population of this research is the eleventh-grade students of SMA Negeri1 Witaponda, the sample was XI IPS2 as experimental class and XI IPS3 as control class. The number of each sample was 21 students. The research applied quantitative method. The instruments of the data collection were pre-test and post-test. The finding showed that the experimental group's mean score on the post-test was 72 and the pretest was 56.6. Whereas the control group's mean score on the post-test is 45.7 and the pretest is 53.5. The results of data analysis revealed that the value of the t-counted (3.804) was higher than the value of the t-table (1.684) by applying a significant level of 0.05 with a degree of freedom (df). It means that the hypothesis is accepted. It indicates that there is a significant improvement. In addition, the implications of these findings can be concluded that the use of demonstration techniques was effective for teaching writing procedure texts because it can help practice their ideas and help teachers transfer material related to the lesson.
Mapping rheumatoid arthritis susceptibility through integrative bioinformatics and genomics Medi Sushanti, Nining; Adikusuma, Wirawan; Afief, Arief Rahman; La’ah, Anita Silas; Firdayani, Firdayani; Chong, Rockie; Zakaria, Zainul Amiruddin; Purwanto, Barkah Djaka; Satria, Rahmat Dani; Khair, Riat; Septama, Abdi Wira; Irham, Lalu Muhammad
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.24912

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that influences several organs and tissues, especially the synovial joints, and is associated with multiple genetic and environmental factors. Numerous databases provide information on the relationship between a specific gene and the disease pathogenesis. However, it is important to further prioritize biological risk genes for downstream development and validation.  This study aims to map RA-association genetic variation using genome-wide association study (GWAS) databases and prioritize influential genes in RA pathogenesis based on functional annotations. These functional annotations include missense/nonsense mutations, cis-expression quantitative trait locus (cis-eQTL), overlap knockout mouse phenotype (KMP), protein-protein interaction (PPI), molecular pathway analysis (MPA), and primary immunodeficiency (PID). 119 genetic variants mapped had a potential high risk for RA based on functional scoring. The top eight risk genes of RA are TYK2 and IFNGR2, followed by TNFRSF1A, IL12RB1 and CD40, C5, NCF2, and IL6R. These candidate genes are potential biomarkers for RA that can aid drug discovery and disease diagnosis.
Interpretasi Imajif dan Emosif melalui Metafora dalam Antologi Puisi Melipat Jarak Karya Sapardi Djoko Damono dan Relevansinya terhadap Pembelajaran Sastra di SMP Firdayani, Firdayani; Anshari, Anshari; Sulastriningsih Djumingin
Jurnal Onoma: Pendidikan, Bahasa, dan Sastra Vol. 11 No. 2 (2025)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/onoma.v11i2.5508

Abstract

Penelitian ini bertujuan untuk mendeskripsikan penggunaan metafora dalam membangun imaji dan emosi dalam antologi puisi “Melipat Jarak” karya Sapardi Djoko Damono dan relevansinya terhadap pembelajaran sastra di SMP. Melalui pendekatan kualitatif, penelitian ini mengamati dan menganalisis penggunaan nmetafora dalam membangun imaji dan emosi yang terkandung dalam antologi puisi “Melipat Jarak” sesuai dengan teori linguistik kognitif Lakoff. Data penelitian berupa puisi-puisi “Melipat Jarak” karya Sapardi Djoko Damono. Sumber data dalam penelitian ini yaitu buku antologi puisi karya Sapardi Djoko Damono yang berjudul “Melipat Jarak” yang berjumlah 75 judul puisi. Data dianalisis dengan menggunakan teknik dokumentasi, teknik baca, dan teknik catat. Hasil penelitian ditemukan metafora berupa metafora struktural, metafora orientasional, dan metafora ontologis yang sesuai dengan pengklasifikasian metafora menurut Lakoff. Imaji berupa imaji visual (penglihatan), imaji taktis (rabaan), imaji auditorik (pendengaran), imaji olfaktori (penciuman), imaji gustatori (pengecapan), dan imaji kinestetik (gerak). Emosi berupa emosi positif, emosi negatif dan emosi netral. Pembelajaran sastra di SMP, khususnya puisi memerlukan pendekatan yang tepat untuk membantu siswa memahami makna dan pesan yang terkandung dalam puisi. Interpretasi imajif dan emosif melalui metafora merupakan salah satu pendekatan yang relevan dengan pembelajaran sastra di SMP.
Co-Authors Abdi Wira Septama Afief, Arief Rahman Anshari Anshari, Anshari Azkiyah, Dina Chong, Rockie Gustini Syahbirin Khair, Riat Lalu Muhammad Irham La’ah, Anita Silas Listiana, Shelvi Maf'ulah, Maf’ulah Medi Sushanti, Nining Nadrun, Nadrun Purwantiningsih Sugita Purwanto, Barkah Djaka rofiqoh rofiqoh Rusdial Marta Satria, Rahmat Dani Sulastriningsih Djumingin Wirawan Adikusuma Witanto, Billy Zakaria, Zainul Amiruddin Zulhendri Zulhendri