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All Journal JURNAL KIMIA SAINS DAN APLIKASI KOVALEN: Jurnal Riset Kimia Indonesian Journal of Chemistry Makara Journal of Science
Luthfan Irfana
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Jl. Tanjung Kampus IPB Dramaga, Bogor 16680, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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Blended Film from PVA and Sansevieria trifasciata Dichloromethane Fraction for Reducing Heat Radiation from Smartphones Ilmiawati, Auliya; Pujiyati,; Hidayat, Asep; Sugita, Purwantiningsih; Irfana, Luthfan; Arifin, Budi
Makara Journal of Science Vol. 23, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

It has been reported that the lidah mertua plant (Sansevieria trifasciata) can absorb electromagnetic radiation from vari-ous electronic equipment. The current study aimed to make a film layer from polyvinyl alcohol (PVA) and a dichloro-methane (DCM) fraction of S. trifasciatato reduce heat radiation from smartphones. S. trifasciataleaves were macer-ated using ethanol and partitioned with ethyl acetate, DCM, and n-butanol. The DCM fraction was chosen to create the film, for which PVA was also used. The blended film made from PVA and 0.02% DCM reduced heat radiation from smartphones by up to 4.4 °C starting from the first minute of use; its heat reduction remained stable until the 20th mi-nute. Based on these results, it was determined that the active compounds in the DCM fraction are closely related to saponin-type steroids.
Identifikasi Senyawa Fraksi Larut n-Heksana Rimpang Temu Mangga (Curcuma mangga Val) Menggunakan LC-MS/MS dan Review Potensinya sebagai Antibakteri: Identification of Compounds Soluble n-Hexane Fraction of Rhizome of Temu Mangga (Curcuma mango Val) Using LC-MS/MS and Review of its Potential as Antibacterial Purwantinigsih Sugita; Risda Fardilya Nihayah; Moch Ikkbal Aditya Kasmaran; Gustini Syahbirin; Auliya Ilmiawati; Budi Arifin; Luthfan Irfana
KOVALEN: Jurnal Riset Kimia Vol. 8 No. 2 (2022): August Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2022.v8.i2.15897

Abstract

Plants are like the pharmaceutical industry that provides products that have the potential as active medicinal ingredients. In order to search for compounds useful for health, the purpose of this study was to identify secondary metabolites of Curcuma mango (temu mango) growing in the experimental garden of Biopharmaca LPPM IPB and review its activity as antibacterial. Identification begins with phytochemical screening, then separation and purification by chromatographic techniques. Intersection mango simplicia was extracted with methanol, and the crude extract of methanol was partitioned with n-hexane, ethyl acetate, and methanol, respectively. The n-hexane soluble fraction was carried out by phytochemical tests, fractionation by vacuum liquid chromatography (KCV) and radial (KR), and the selected fractions was analyzed by LC-MS/MS. The results of the phytochemical test of the soluble n-hexane fraction showed a positive presence of alkaloids and terpenoids through successive tests with Mayer, Wagner, Dragendorff (alkaloid), and Lieberman-Burchard reagents. Fractionation of the n-hexane soluble fraction with KCV resulted in 9 fractions (H1-H9) and the H5 fraction showed good separation between spots in the n-hexane: ethyl acetate eluent mixture (97:3). Purification of H5 with KR obtained 7 fractions (H5.1-H5.7). Based on LC-MS/MS, the H5.2 fraction was dominated by the terpenoid group, and the results of the literature review showed the contribution of terpenoids as antibacterial compounds
Films from PVA and Sansevieria trifasciata Leaves Extracts as a Smartphone Protector with Radiation Reducing Property and Its LC-MS Analysis Auliya Ilmiawati; Melinia Falestin; Akhiruddin Maddu; Luthfan Irfana; Purwantiningsih Sugita; Budi Arifin
Indonesian Journal of Chemistry Vol 23, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76809

Abstract

Sansevieria trifasciata (mother-in-law's tongue), an ornamental plant widely found in Indonesia, can absorb electromagnetic radiation in various electronic devices. This study aims to find the best S. trifasciata extract as an electromagnetic and thermal radiation reducer emitted from a smartphone. S. trifasciata leaves were macerated using ethanol, acetone, and dichloromethane. The extract was mixed with PVA as a film and tested for electromagnetic radiation using a radiation measuring device type GM-3120. Thermal radiation was tested using a temperature sensor (PASCO CI-6505B) connected to a PASCO 550 Universal Interface. All smartphone protective films decreased radiation from the smartphone, and the acetone extract caused the most significant radiation decrease, with the best results at a concentration of 5%. An S. trifasciata extract contained alkaloids, saponins, steroids, phenolics, and tannins based on the phytochemical tests. Based on LC-MS data, the dominant compounds identified from the three extracts of S. trifasciata is a group of alkaloids, fatty acid, and steroid. The functional groups that are thought to play a role in reducing radiation are the C-O, C=O, and C-OH functional groups. A compound that is thought to contribute to the reduction in radiation is neuroscogenin, a steroid group.
In Silico Screening Anticancer of Six Triterpenoids toward miR-494 and TNF-α Targets Vikra Ardiansyah Zaini; Purwantiningsih Sugita; Luthfan Irfana; Suminar Setiati Achmadi
Jurnal Kimia Sains dan Aplikasi Vol 23, No 4 (2020): Volume 23 Issue 4 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3049.44 KB) | DOI: 10.14710/jksa.23.4.117-123

Abstract

Hepatocellular carcinoma (HCC) accounts for up to 90% of all primary liver cancers worldwide. Cinobufagin is recognized to inhibit miR-494 as the HCC target. Increased expression of TNF-α results in an inadequate response to liver anticancer drugs. The models in this study were cinobufagin, cycloartenol, and ethyl acetate fractions of Ganoderma lucidum, 2–5. Seven docking targets in this study were Akt, ERK1, ERK2, PI3K, TNF-α, TNFR1, and TNFR2. Cycloartenol and compound 4 comply with Veber’s rules, Lipinski’s rule of 5, and demonstrate moderate toxicity. The action implies a potential docking target since it produces bond affinities with the compound 2–5 that agree with the IC50 in the literature, which is based on in vitro experiments. Akt as a receptor target is AZD5363. Cycloartenol shows a low ability to inhibit Akt. Conversely, compound 4 inhibits the Akt better than that of cycloartenol, although it is not as good as cinobufagin and AZD5363. Therefore, compound 4, a triterpenoid with a basic framework of lanostane has the potential to be an anticancer candidate for the liver.
Co-Authors Akhiruddin Maddu Asep Hidayat Asep Hidayat Auliya Ilmiawati Budi Arifin Gustini Syahbirin Melinia Falestin Moch Ikkbal Aditya Kasmaran Pujiyati Pujiyati Pujiyati, Purwantinigsih Sugita Purwantiningsih Sugita Purwantiningsih Sugita Purwantiningsih Sugita Risda Fardilya Nihayah SUMINAR SETIATI ACHMADI Vikra Ardiansyah Zaini