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All Journal HAYATI Journal of Biosciences VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Riset Kimia Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat EduChemia: Jurnal Kimia dan Pendidikan KOVALEN: Jurnal Riset Kimia JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Indonesian Journal of Chemistry Jurnal Jamu Indonesia Jurnal Pusat Inovasi Masyarakat Makara Journal of Science Indonesian Journal of Jamu
Auliya Ilmiawati
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Bogor 16680, Indonesia. Tropical Biopharmaca Research Center-Institute Of Research And Community Services, IPB University, Bogor 16128, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Antioxidant Capacity, Phytochemical Profile, and Clustering of Pomegranate (Punica granatum L.) Peel Extracts Using Different Solvent Extraction Rafi, Mohamad; Wulansari, Laela; Septaningsih, Dewi Anggraini; Purnomo, Tsania Firqin; Auliatifani, Reza; Khaydanur, Khaydanur; Ilmiawati, Auliya; Yulianti, Wina; Nengsih, Nunuk Kurniati; Suparto, Irma Herawati; Kusuma, Wisnu Ananta
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pomegranate has valuable nutritional content and contains various bioactive compounds, one found in the fruit's peel. The utilization of these bioactive compounds could be used as herbal medicines and supplements, such as antioxidants. This study aimed to determine the antioxidant capacity, phytochemical profile, and pomegranate peel extract grouping using different extracting solvents. The three extracting solvents used were water, 70% ethanol, and ethanol p.a. Antioxidant capacity of the three extracts was measured using the DPPH and CUPRAC methods. We also determined the total phenolic and flavonoid levels and the TLC fingerprint analysis and FTIR spectrum of the pomegranate peel extracts. The 70% ethanol extract owned the largest antioxidant capacity than the other two extracts with a value of 358.67 and 2981.59 µmol trolox/g dried sample using the DPPH and CUPRAC methods, respectively. The three pomegranate peel extracts' total phenolic and flavonoid levels ranged from 287.26–1068.81 mg GAE/g dried sample and 0.24-0.75 mg QE/g dried sample. TLC fingerprint analysis of pomegranate peel extract yielded 2, 6, and 6 bands for water extract, 70% ethanol, and p.a ethanol, respectively. The three extracts can be grouped based on FTIR spectrum data using principal component analysis using three principal components with a total variance of 93%. The results obtained show that using different extracting solvents provides different antioxidant capacities and phytochemical profiles.
Potensi Beberapa Ekstrak Tumbuhan Asteraceae sebagai Antioksidan dan Antiglikasi Eka Budiarti; Irmanida Batubara; Auliya Ilmiawati
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1282.474 KB) | DOI: 10.29244/jji.v4i3.161

Abstract

Tumbuhan Asteraceae dilaporkan mengandung metabolit sekunder tinggi yang aktif sebagai antioksidan. Senyawa antioksidan juga digunakan untuk mencegah penuaan/reaksi glikasi. Penelitian ini bertujuan menentukan aktivitas antioksidan dan antiglikasi 7 tumbuhan Asteraceae. Daun Adenostema lavenia, Ageratum conyzoides, Dichrocephala integrifolia, Galinsoga parvifolia, Synedrella nodiflora, Mikania micrantha, dan Sphagneticola trilobata masing-masing diekstraksi menggunakan air. Ekstrak kemudian ditentukan kandungan total fenol, flavonoid, dan aktivitas antioksidan menggunakan metode 1,1-difenil-2-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid (ABTS), serta aktivitas antiglikasi. Ekstrak dengan kadar total fenolik dan flavonoid tertinggi adalah ekstrak M. micrantha. Ekstrak A. lavenia memiliki aktivitas antioksidan terhadap DPPH tertinggi dengan nilai IC50 sebesar 121,82 μg/mL dan A. conyzoides tertinggi terhadap ABTS dengan kapasitas sebesar 4,51 mg trolox ekivalen (TE)/g ekstrak. Aktivitas antiglikasi tertinggi pada ekstrak G. parvifolia sebesar 90,67% yang tidak berbeda nyata dengan ekstrak A. lavenia (87,87%) dan S. trilobata (87,38%). Secara keseluruhan ekstrak A. lavenia dan S. trilobata baik dikembangkan sebagai antioksidan dan antiglikasi.
Blended Film from PVA and Sansevieria trifasciata Dichloromethane Fraction for Reducing Heat Radiation from Smartphones Ilmiawati, Auliya; Pujiyati,; Hidayat, Asep; Sugita, Purwantiningsih; Irfana, Luthfan; Arifin, Budi
Makara Journal of Science Vol. 23, No. 2
Publisher : UI Scholars Hub

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Abstract

It has been reported that the lidah mertua plant (Sansevieria trifasciata) can absorb electromagnetic radiation from vari-ous electronic equipment. The current study aimed to make a film layer from polyvinyl alcohol (PVA) and a dichloro-methane (DCM) fraction of S. trifasciatato reduce heat radiation from smartphones. S. trifasciataleaves were macer-ated using ethanol and partitioned with ethyl acetate, DCM, and n-butanol. The DCM fraction was chosen to create the film, for which PVA was also used. The blended film made from PVA and 0.02% DCM reduced heat radiation from smartphones by up to 4.4 °C starting from the first minute of use; its heat reduction remained stable until the 20th mi-nute. Based on these results, it was determined that the active compounds in the DCM fraction are closely related to saponin-type steroids.
Phenolic Compound in Garlic (Allium sativum) and Black Garlic Potency as Antigout Using Molecular Docking Approach Ayu Rahmania Lestari; Irmanida Batubara; Setyanto Tri Wahyudi; Auliya Ilmiawati
Jurnal Kimia Sains dan Aplikasi Vol 25, No 7 (2022): Volume 25 Issue 7 Year 2022
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.25.7.253-263

Abstract

Phenolics, including flavonoids, are bioactive components in garlic in relatively abundant amounts and are present 2–4 times more in black garlic. Both of these compounds are reported to have biological activity, with one of them acting as an antioxidant. However, its ability as an antigout is still not widely reported. Xanthine oxidase, adenine deaminase, guanine deaminase, purine nucleoside phosphorylase, and 5-Nucleotidase II are involved during the production of uric acid and causes gout. This study predicted the potential of the phenolic and flavonoid compounds in garlic and black garlic as antigout in inhibiting five target receptors through a molecular docking approach. Utilizing AutoDock Tools v.1.5.7 for receptor and ligand preparation, AutoDock Vina and AutoDock4 for molecular docking, and LigPlot+ and PyMOL for visualization. About 21 compounds from the phenolic and flavonoid groups were used as test ligands and 16 reference ligands (substrate and commercial). SwissADME predicted the pharmacokinetic parameters. The results showed that apigenin, morin, resveratrol, kaempferol, (+)-catechin, isorhamnetin, and (-)-epicatechin were predicted to have good interactions at each target receptor and had the potential to be developed as candidates for multi-target antigout. Based on the pharmacokinetic parameters, all these compounds had good scores in each, making them feasible to continue in vitro or in vivo trials.
Identifikasi Senyawa Fraksi Larut n-Heksana Rimpang Temu Mangga (Curcuma mangga Val) Menggunakan LC-MS/MS dan Review Potensinya sebagai Antibakteri: Identification of Compounds Soluble n-Hexane Fraction of Rhizome of Temu Mangga (Curcuma mango Val) Using LC-MS/MS and Review of its Potential as Antibacterial Purwantinigsih Sugita; Risda Fardilya Nihayah; Moch Ikkbal Aditya Kasmaran; Gustini Syahbirin; Auliya Ilmiawati; Budi Arifin; Luthfan Irfana
KOVALEN: Jurnal Riset Kimia Vol. 8 No. 2 (2022): August Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2022.v8.i2.15897

Abstract

Plants are like the pharmaceutical industry that provides products that have the potential as active medicinal ingredients. In order to search for compounds useful for health, the purpose of this study was to identify secondary metabolites of Curcuma mango (temu mango) growing in the experimental garden of Biopharmaca LPPM IPB and review its activity as antibacterial. Identification begins with phytochemical screening, then separation and purification by chromatographic techniques. Intersection mango simplicia was extracted with methanol, and the crude extract of methanol was partitioned with n-hexane, ethyl acetate, and methanol, respectively. The n-hexane soluble fraction was carried out by phytochemical tests, fractionation by vacuum liquid chromatography (KCV) and radial (KR), and the selected fractions was analyzed by LC-MS/MS. The results of the phytochemical test of the soluble n-hexane fraction showed a positive presence of alkaloids and terpenoids through successive tests with Mayer, Wagner, Dragendorff (alkaloid), and Lieberman-Burchard reagents. Fractionation of the n-hexane soluble fraction with KCV resulted in 9 fractions (H1-H9) and the H5 fraction showed good separation between spots in the n-hexane: ethyl acetate eluent mixture (97:3). Purification of H5 with KR obtained 7 fractions (H5.1-H5.7). Based on LC-MS/MS, the H5.2 fraction was dominated by the terpenoid group, and the results of the literature review showed the contribution of terpenoids as antibacterial compounds
Antioxidant Capacity, Phytochemical Profile, and Clustering of Pomegranate (Punica granatum L.) Peel Extracts Using Different Solvent Extraction Mohamad Rafi; Laela Wulansari; Dewi Anggraini Septaningsih; Tsania Firqin Purnomo; Reza Auliatifani; Khaydanur Khaydanur; Auliya Ilmiawati; Wina Yulianti; Nunuk Kurniati Nengsih; Irma Herawati Suparto; Wisnu Ananta Kusuma
Journal of Tropical Life Science Vol. 11 No. 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.14

Abstract

Pomegranate has valuable nutritional content and contains various bioactive compounds, one found in the fruit's peel. The utilization of these bioactive compounds could be used as herbal medicines and supplements, such as antioxidants. This study aimed to determine the antioxidant capacity, phytochemical profile, and pomegranate peel extract grouping using different extracting solvents. The three extracting solvents used were water, 70% ethanol, and ethanol p.a. Antioxidant capacity of the three extracts was measured using the DPPH and CUPRAC methods. We also determined the total phenolic and flavonoid levels and the TLC fingerprint analysis and FTIR spectrum of the pomegranate peel extracts. The 70% ethanol extract owned the largest antioxidant capacity than the other two extracts with a value of 358.67 and 2981.59 µmol trolox/g dried sample using the DPPH and CUPRAC methods, respectively. The three pomegranate peel extracts' total phenolic and flavonoid levels ranged from 287.26–1068.81 mg GAE/g dried sample and 0.24-0.75 mg QE/g dried sample. TLC fingerprint analysis of pomegranate peel extract yielded 2, 6, and 6 bands for water extract, 70% ethanol, and p.a ethanol, respectively. The three extracts can be grouped based on FTIR spectrum data using principal component analysis using three principal components with a total variance of 93%. The results obtained show that using different extracting solvents provides different antioxidant capacities and phytochemical profiles.
UHPLC-Q-Orbitrap HRMS-based Untargeted Metabolomics of Sida rhombifolia Leaves and Stem Extracts Alfi Hudatul Karomah; Mohamad Rafi; Dewi Anggraini Septaningsih; Auliya Ilmiawati; Utami Dyah Syafitri; Nanik Siti Aminah; Muhamad Insanu; Abdul Rohman
HAYATI Journal of Biosciences Vol. 30 No. 4 (2023): July 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.4.770-778

Abstract

Sida rhombifolia, also known as sidaguri in Indonesia, is a medicinal plant commonly used as a herbal medicine because of its metabolite and biological activities. One of the several factors that affect plant metabolite composition and concentration is the use of plant parts. In this study, the experiment aimed to identify the metabolite profile in the leaves and stem extracts of S. rhombifolia using UHPLC-Q-Orbitrap HRMS-based untargeted metabolomics. The samples were distinguished by principal component analysis (PCA). Extraction of metabolites was conducted by sonication for approximately 30 min with 70% ethanol as the extraction solvent; 28 metabolites were identified. Seven metabolites were identified only in the leaves, three were identified only in the stems, and 18 other metabolites were identified in both the leaves and stems. These metabolites were categorized as flavonoids, triterpenoids, alkaloids, coumarins, phenolic aldehydes, phenolic acids, ecdysteroids, fatty acids, and monoterpene lactones. Based on the classification results, PCA grouped the leaves and stem extracts of S. rhombifolia using the peak area variables of the identified metabolites.
Peningkatan Nilai Tambah Tanaman Obat pada Pekarangan Rumah Ibu-ibu PKK (Pemberdayaan Kesejahteraan Keluarga) Kecamatan Pasirwangi, Kabupaten Garut Siti Sadiah; Sandra Arifin Aziz; Auliya Ilmiawati; Taopik Ridwan
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 2 (2023): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.9.2.199-205

Abstract

Polyscias scutellaria can be planted as hedge plants at home. This plant has many advantages, one of which is a hair tonic that already has a patent number. To be used on an industrial scale, it is necessary to provide raw materials on a large scale, which can be done by planting in certain regions. The objective is that the empowerment of the PKK in Pasirwangi District, Garut will make the Pasirwangi sub-district one of the centers for producing P. scutellaria leaf raw materials. The activities carried out include educating on the use of medicinal plants, especially P. scutellaria and ginger, practicing training on planting techniques, cultivating them, and giving P. scutellaria cuttings and post-harvest processing techniques. This activity is an activity of the IPB Lecturer Homecoming Program in 2022 which is carried out in several stages. Evaluation and monitoring of cultivation executed two months after training. The evaluation results showed that there was an increase in knowledge related to the cultivation of P. scutellaria and participants cultivated P. scutellaria in their garden after the training was more than 90%. All of the participant’s responses to the training carried out stated that it was very useful and hoped that the activities would be sustainable.
Fitokimia, Kadar Fenolik Total, dan Flavonoid Total serta Aktivitas Antioksidan Ekstrak n-Heksana Rimpang Temu Hitam (Curcuma aeruginosa Roxb) Auliya Ilmiawati; Ika Resmeiliana; Ishika Jauza Nasywa; Fadia Fahira; Nafisa Muthia Wafa; M. Raffi Rayandhika; Andi Thaariq Muhammad; Arini Septianti; Hafizah Fatunisa
Jurnal Riset Kimia Vol. 14 No. 2 (2023): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v14i2.599

Abstract

The rhizome of black turmeric (Curcuma aeruginosa) is a plant rich in benefits and has been used as a herbal medicine to treat various health problems. This study aims to obtain the n-hexane extract of black turmeric rhizome and perform phytochemical tests, determine total phenolic and total flavonoid levels, as well antioxidant tests using the DPPH method. Extraction of n-hexane from black turmeric rhizome obtained yield of 4.88%, total phenolic content of 3.01 mg QE/g extract and total flavonoids of 6.31 mg QE/g extract. The phytochemical test obtained positive results for the presence of alkaloids and flavonoids; negative tannins, steroids/triterpenoids and saponins. Antioxidant tests using the DPPH method obtained the percentage of DPPH capture ranging from 76-78%, with the largest percentage value obtained when the extract concentration was 125 ppm, which was 78.02%. This shows that black turmeric n-hexane extract has weak antioxidant activity.
Films from PVA and Sansevieria trifasciata Leaves Extracts as a Smartphone Protector with Radiation Reducing Property and Its LC-MS Analysis Auliya Ilmiawati; Melinia Falestin; Akhiruddin Maddu; Luthfan Irfana; Purwantiningsih Sugita; Budi Arifin
Indonesian Journal of Chemistry Vol 23, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76809

Abstract

Sansevieria trifasciata (mother-in-law's tongue), an ornamental plant widely found in Indonesia, can absorb electromagnetic radiation in various electronic devices. This study aims to find the best S. trifasciata extract as an electromagnetic and thermal radiation reducer emitted from a smartphone. S. trifasciata leaves were macerated using ethanol, acetone, and dichloromethane. The extract was mixed with PVA as a film and tested for electromagnetic radiation using a radiation measuring device type GM-3120. Thermal radiation was tested using a temperature sensor (PASCO CI-6505B) connected to a PASCO 550 Universal Interface. All smartphone protective films decreased radiation from the smartphone, and the acetone extract caused the most significant radiation decrease, with the best results at a concentration of 5%. An S. trifasciata extract contained alkaloids, saponins, steroids, phenolics, and tannins based on the phytochemical tests. Based on LC-MS data, the dominant compounds identified from the three extracts of S. trifasciata is a group of alkaloids, fatty acid, and steroid. The functional groups that are thought to play a role in reducing radiation are the C-O, C=O, and C-OH functional groups. A compound that is thought to contribute to the reduction in radiation is neuroscogenin, a steroid group.
Co-Authors Abdul Rohman Adiba, Asfiah Agusta, Dhea Demitri Akhiruddin Maddu Alfi Hudatul Karomah Andi Thaariq Muhammad Arinana Arinana Arini Septianti Asep Hidayat Asep Hidayat Asyari, R. Mugni Chairil Arbi Auliatifani, Reza Ayu Rahmania Lestari Bambang Pontjo Priosoeryanto Budi Arifin Budi Arifin Budi Arifin Budiarti, Eka Desi Wulandari, Desi Eka Budiarti Erlina, Iis Fadia Fahira Fadilah, Nisa Lelita Failasufa, Adzkia Febriany, Retno Putri Fiqri, Muhammad Gustini Syahbirin Gustini Syahbirin Hafizah Fatunisa Hanhan Dianhar Ika Resmeiliana Irma Herawati Suparto Irmanida Batubara Ishika Jauza Nasywa Kenang Sagraha, Ghiffari Khaydanur Khaydanur Khaydanur, Khaydanur Kurniawanti, Kurniawanti Laela Wulansari Larasati, Rizki Marsha Lutfia Mutmainnah Luthfan Irfana Luthfan Irfana Luthfan Irfana M. Raffi Rayandhika Melinia Falestin Moch Ikkbal Aditya Kasmaran Mohamad Rafi Mohamad Rafi Mohamad Rafi Muhamad Insanu Mujahidah, Ummahatul Nafisa Muthia Wafa Nanik Siti Aminah Nasution, Lise Meitner Aribah Nazhifah, Athiq Nengsih, Nunuk Kurniati Ningtias, Widya Sekar Ayu Nunuk Kurniati Nengsih Priandanda, Rafi Chandra Pujiyati Pujiyati Pujiyati, Purnomo, Tsania Firqin Purwantinigsih Sugita Purwantiningsih Sugita Purwantiningsih Sugita Rahayu, Dyah Utami Cahyaning Rahmah, Lutfita Anisa Rahmani, Nabiila Reza Auliatifani Risda Fardilya Nihayah Sagraha, Ghiffari Kenang Sandra Arifin Aziz Septaningsih, Dewi Anggraini Setyanto Tri Wahyudi Siti Sadiah Taopik Ridwan Tsania Firqin Purnomo Utami Dyah Syafitri Wina Yulianti Wisnu Ananta Kusuma Wulansari, Laela Yulianti, Dwi Indah