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All Journal Journal of Educational Innovation and Public Health
Ibnu Abqori
Universitas Tjut Nyak Dhien
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Penetapan Kadar Senyawa Obat Sulfadiazin Generik dan Paten dengan Metode Titrasi Bromometri Nilsya Zebua; Ristina Hasibuan; Syarifah Nadia; Khiru Nisa; Ibnu Abqori; Haya Meisha Nova; Habibatu Rohma; Fitri Khadrah Ardiany; Fina Cornelya Batubara; Ananda Wulan Sari Halwa
Journal of Educational Innovation and Public Health Vol. 4 No. 4 (2026): Oktober : Journal of Educational Innovation and Public Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i4.10371

Abstract

Background: Quantitative analysis of pharmaceutical preparations is essential to ensure active ingredient purity and content comply with quality standards. Sulfadiazine is a sulfonamide antibiotic whose content can be determined using bromometric redox titration. Objective: This study aimed to determine and compare the concentration of sulfadiazine in generic and patented dosage forms using the bromometric titration method. Methods: Assays were performed in triplicate (). Samples were dissolved in concentrated  and reacted with excess 0.1 N  and  to generate  gas in situ. The excess  was reacted with  and back-titrated using 0.1 N  with starch indicator until the blue color disappeared. Results: The mean concentration of generic sulfadiazine was  (, , and ), while the patented formulation was  (, , and ). Both preparations complied with the Indonesian Pharmacopoeia requirements (). Conclusion: There was no significant difference in active ingredient concentration between generic and patented preparations (0.36% difference), proving that generic sulfadiazine has equivalent quality and chemical efficacy to its patented counterpart.
Co-Authors Ananda Wulan Sari Halwa Fina Cornelya Batubara Fitri Khadrah Ardiany Habibatu Rohma Haya Meisha Nova Khiru Nisa Nilsya Febrika Zebua, Nilsya Febrika Ristina Hasibuan Syarifah Nadia