Penetapan Kadar Senyawa Obat Sulfadiazin Generik dan Paten dengan Metode Titrasi Bromometri

Nilsya Zebua (Universitas Tjut Nyak Dhien)
Ristina Hasibuan (Universitas Tjut Nyak Dhien)
Syarifah Nadia (Universitas Tjut Nyak Dhien)
Khiru Nisa (Universitas Tjut Nyak Dhien)
Ibnu Abqori (Universitas Tjut Nyak Dhien)
Haya Meisha Nova (Universitas Tjut Nyak Dhien)
Habibatu Rohma (Universitas Tjut Nyak Dhien)
Fitri Khadrah Ardiany (Universitas Tjut Nyak Dhien)
Fina Cornelya Batubara (Universitas Tjut Nyak Dhien)
Ananda Wulan Sari Halwa (Universitas Tjut Nyak Dhien)

Journal of Educational Innovation and Public Health
Vol. 4 No. 4 (2026): Oktober : Journal of Educational Innovation and Public Health

Background: Quantitative analysis of pharmaceutical preparations is essential to ensure active ingredient purity and content comply with quality standards. Sulfadiazine is a sulfonamide antibiotic whose content can be determined using bromometric redox titration. Objective: This study aimed to determine and compare the concentration of sulfadiazine in generic and patented dosage forms using the bromometric titration method. Methods: Assays were performed in triplicate (). Samples were dissolved in concentrated  and reacted with excess 0.1 N  and  to generate  gas in situ. The excess  was reacted with  and back-titrated using 0.1 N  with starch indicator until the blue color disappeared. Results: The mean concentration of generic sulfadiazine was  (, , and ), while the patented formulation was  (, , and ). Both preparations complied with the Indonesian Pharmacopoeia requirements (). Conclusion: There was no significant difference in active ingredient concentration between generic and patented preparations (0.36% difference), proving that generic sulfadiazine has equivalent quality and chemical efficacy to its patented counterpart.