Muhammad zaharul ichsan
Universitas Sumatera Utara

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Pengaruh Pemberian Ekstrak Buah Gandaria terhadap Profil Darah Tikus yang Diinduksi Karbon Tetraklorida Muhammad zaharul ichsan; syafruddin Ilyas; Masitta Tanjung
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 9 No. 4 (2026): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/pb7cvp76

Abstract

This study aims to analyze the antioxidant potential of gandaria fruit extract against carbon tetrachloride-induced free radicals based on complete blood profile analysis in experimental animals. The method used was a completely randomized design with 30 rats divided into six treatment groups, namely normal, negative, positive, and three gandaria fruit extract treatment groups at doses of 200, 400, and 600 mg/kg BW. The results showed that gandaria fruit extract had a significant effect in improving blood profile damage after CCl4 induction, contained alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins, had total phenolic content of 6133 mg/kg, antioxidant inhibition activity of 81%, and an IC50 value of 90 ppm. In conclusion, gandaria fruit extract at a dose of 600 mg/kg BW was the best dose and showed potential as a hematoprotective agent. Keywords: Blood Profile, Bouea Macrophylla, Carbon Tetrachloride, Plum Mango.