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All Journal JCPS (Journal of Current Pharmaceutical Sciences)
Siti Eka Amalia
Universitas Negeri Gorontalo
Medicine & Pharmacology

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In Vitro and In Silico Evaluation of Butterfly Pea Flower (Clitoria ternatea) Extract in Fast-Disintegrating Tablets Mohamad Aprianto Paneo; Siti Eka Amalia; Multiani S Latif; Aris Purwanto; Firman Gustaman; Djayadi Azis
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1813

Abstract

Clitoria ternatea flowers contain flavonoids of interest for pharmaceutical development. This study examined a single fast-disintegrating tablet prototype containing a sequential methanol extract and explored quercetin docking against cyclooxygenase-2 (COX-2). Dried flower powder (100 g) was successively macerated with n-hexane, ethyl acetate, and methanol. The methanol extract was selected based on extraction yield and qualitative flavonoid screening. Tablets containing 250 mg extract at a theoretical mass of 490 mg were evaluated for hardness, disintegration, friability, and dissolution. Extraction yields were 2.15%, 7.35%, and 12.80%, respectively. Reported hardness was 4.25 ± 0.09 kg on the instrument scale, disintegration time was 42.8 ± 1.4 s, and friability was 0.41%. The reported UV–Vis dissolution response reached 93.7 ± 1.6% at 30 min. However, analytical marker, wavelength, calibration details, and replicate structure were insufficiently documented, limiting quantitative interpretation. Quercetin was selected from the literature and was not specifically identified or quantified in the extract. Docking scores were −9.7 kcal/mol for quercetin and −6.8 kcal/mol for the diclofenac comparator. Native-ligand redocking and RMSD results were unavailable, and the hardness summary requires verification against individual measurements. These findings describe an initial tablet prototype and a separate computational hypothesis. They do not establish an optimized formulation, quercetin-specific release, COX-2 inhibition, or anti-inflammatory efficacy. Further analytical characterization, process documentation, docking validation, and biological testing are needed.
Co-Authors Aris Purwanto Djayadi Azis Firman Gustaman Mohamad Aprianto Paneo Multiani S Latif