Article Per Year (5 Year)
p-Index From 2021 - 2026
0.562
P-Index
This Author published in this journals
All Journal Herb-Medicine Journal Indonesian Journal of Innovation Science and Knowledge
Yusuf Adi Gunawan
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Effect of a Single Hemodialysis Session on Platelet Count, Lymphocyte Count, and Platelet-to-Lymphocyte Ratio in Hospitalized Patients with Chronic Kidney Disease Desinta Farah Putri Hartanto; Ratna Wulan Febriyanti; Yusuf Adi Gunawan; Mohammad Nurrizki Haitamy
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol. 9 No. 2 (2026): Herb-Medicine Journal October 2026
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v9i2.30967

Abstract

Chronic Kidney Disease (CKD) stage V is the final stage of kidney disease that requires kidney replacement therapy in the form of hemodialysis. Hemodialysis is known to trigger a systemic inflammatory response that potentially affects hematological parameters, including the Platelet-to-Lymphocyte Ratio (PLR). This study aims to determine the effect of hemodialysis on changes in platelet count, lymphocyte count, and PLR in hospitalized patients with stage V CKD at Purwokerto Islamic Hospital. This analytical study used a retrospective observational design with a paired pre–post design and involved 45 adult patients (≥18 years) with stage V CKD who underwent routine hemodialysis twice per week for 4-5 hours per session at RSI Purwokerto. Data on platelet count, lymphocyte count, and PLR values before and after one hemodialysis session were obtained from medical records. The normality of the data was tested using the Shapiro– Wilk test. A paired t-test was used for data that were normally distributed, while the signed-rank Wilcoxon test was used for data that were not normally distributed, with a significance level of p <0.05. A total of 45 patients met the study criteria. The average platelet count changed from 264.53±145.10 ×10³/μL before hemodialysis to 264.33±125.48 ×10³/μL after hemodialysis (p=0.133). The average lymphocyte count increased from 11.42±7.93 to 12.50±13.56 (p=0.488). The average PLR increased from 39.99±55.88 before hemodialysis to 44.90±53.24 after hemodialysis, but the difference was not statistically significant (p=0.692). In conclusion, one hemodialysis session did not have a significant effect on platelet count, lymphocyte count, or PLR values in stage V CKD patients. These findings suggest that PLR more reflected chronic inflammatory processes than acute hematological changes after one hemodialysis session.
Beyond the Anamnesis: Big Data Reveals Rash, Not Bleeding, as the Critical Predictor of Dengue Shock Syndrome Muhammad Almanfaluthi; Stefani Widodo; Arif Burhanuddin; Irma Putri Damayanti; Yusuf Adi Gunawan
Indonesian Journal of Innovation Science and Knowledge Vol. 3 No. 4 (2026): IJISK 2026
Publisher : Fakultas Pendidikan Ilmu Keguruan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/ijisk.v3i4.810

Abstract

Dengue shock syndrome (DSS) is a critical, life-threatening complication; however, early prediction remains highly challenging. Clinicians historically rely on classic warning signs obtained through subjective anamnesis, such as persistent fever and spontaneous bleeding, to triage patients despite the potential for observational bias. To address this clinical gap, this study aimed to evaluate the objective predictive value of isolated, patient-reported symptoms on the incidence of shock using a large-scale population dataset. A retrospective observational design utilized big data analytics on routine surveillance records from the Banyumas Regional Health Agency, spanning from 2024 to 2025. The analyzed dataset comprised 1,381 patients, and statistical models, including bivariate analyses and logistic regression, were constructed to quantify the association between individual clinical symptoms and shock outcomes. The findings reveal a striking clinical anomaly: classically feared symptoms, including bleeding and fever, lack significant predictive power for shock deterioration. Conversely, the presence of a rash emerges as a critical clinical indicator; patients presenting with a rash demonstrate a nearly twofold increased risk of progressing to shock (OR = 1.95). Relying exclusively on subjective anamnesis and universal symptom profiles proves unpredictable and insufficient for anticipating severe dengue. Therefore, a rash serves as a crucial early red flag for underlying plasma leakage, mandating healthcare providers to move beyond rigid textbook paradigms and adopt a holistic, adaptive diagnostic approach to optimize patient safety.
Defying Demographic Barriers: High Procedural Success of CTO-PCI in a Real-World Irma Putri Damayanti; Rahageng Wida Kusuma; Muhammad Almanfaluthi; Stefani Widodo; Yusuf Adi Gunawan
Indonesian Journal of Innovation Science and Knowledge Vol. 3 No. 4 (2026): IJISK 2026
Publisher : Fakultas Pendidikan Ilmu Keguruan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/ijisk.v3i4.811

Abstract

Chronic Total Occlusion (CTO) historically represented the "final frontier" in percutaneous coronary intervention, frequently resulting in surgical referral due to high failure rates. Procedural success was traditionally hypothesized to be limited by patient-specific demographic factors, such as advanced age and female gender, alongside the urgency of clinical presentation. To address this clinical gap, this study aimed to evaluate the real-world success rates of CTO interventions and determine whether these baseline demographic and clinical factors significantly predict procedural outcomes. A retrospective observational study was conducted using big data analytics on a catheterization logbook from a high-volume center, yielding a cohort of 187 patients who underwent CTO-PCI. Procedural outcomes, age, gender, and clinical status (emergency vs. elective) were evaluated using bivariate analysis and multivariable logistic regression. The findings reveal an exceptionally high overall procedural success rate of 93.0%. Statistical modeling demonstrates that advanced age, female gender, and emergency clinical status do not significantly predict procedural failure. Operator expertise and advanced crossing techniques effectively neutralize the anatomical complexities traditionally associated with adverse demographic profiles. In conclusion, CTO-PCI is highly safe and efficacious across diverse patient demographics; thus, patients must not be denied minimally invasive revascularization based on perceived, yet statistically unproven, demographic limitations.
Co-Authors Arif Burhanuddin Desinta Farah Putri Hartanto Irma Putri Damayanti Mohammad Nurrizki Haitamy Muhammad Almanfaluthi Rahageng Wida Kusuma Ratna Wulan Febriyanti Stefani Widodo