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All Journal Herb-Medicine Journal
Ratna Wulan Febriyanti
Universitas Muhammadiyah Purwokerto
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Lung Tuberculosis with Multi Drug Resistant Risk in Tertiary Hospital in Middle Java Ratna Wulan Febriyanti; Winarto Winarto; Mujahidah Mujahidah; Endang Sri Lestari; Purnomo Hadi; Vincentia Rizke Ciptaningtyas
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 2 (2021): Herb-Medicine Journal April 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i2.10352

Abstract

World TB report from World Health Organization (WHO) in 2017 informed that Indonesia was second country with TB case. Multi Drug Resistance pulmonary infection’s case in Indonesia were 12.000. Kariadi hospital is one of tertiary hospital for pulmonary MDR-TB treatment but, there is no study about risk factor of it yet, so it needed to find risk factors of MDR-TB pulmonary infection in Kariadi hospital. Cross Sectional design using secondary data from Medical Record  from January 1st -  December 31, 2017 with result of Mycobacterium tuberculosis on GeneXpert sputum examination. Bivariate analysis with Chi square test and multivariate analysis was done by multiple logistic regression. The p value was considered significant if <0.05, all analyzes were 2-tailed. Totally 110 patients were obtained during periode, 55 samples for case and 55 samples for control. There were correlation between smoking habit OR = 3,1 (CI 95% 1,1-8,7), malnutrition OR = 2,9 (CI 95% 1,3-6,3), contact with patient with MDR pulmonary TB infection OR = 12,0 (CI 95% 1,5-97,3), past treatment  OR = 81,7(CI 95% 23,4-285,2) and ≥6months past treatment OR = 94,5 (CI 95% 12,1-736,2. Risk factor that could influence together were contact with patient with MDR pulmonary TB infection OR = 34,5 (CI 95% 2,6-464,5), past treatment OR = 39,4 (CI 95% 8,3-186,3) and ≥ 6months past treatment OR = 12,4 (CI 95% 1,3-117,7). Risk factors for the incidence of pulmonary MDR TB infection are past contact with patient with MDR pulmonary TB infection, past treatment  and  ≥ 6months past treatment.
The Correlation Between Hemoglobin Levels and Length of Hospital Stay in Patients with Pulmonary Tuberculosis at Rumah Sakit Islam Purwokerto Puti Taqwa; Ratna Wulan Febriyanti; Rizka Adi Nugraha Putra; Mustika Ratnaningsih Purbowati
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol. 9 No. 2 (2026): Herb-Medicine Journal October 2026
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v9i2.30904

Abstract

Pulmonary tuberculosis (TB) remains a major global and national health problem, with anemia commonly observed in TB patients due to chronic inflammation affecting iron metabolism and erythropoiesis. Hemoglobin levels are thought to influence clinical outcomes, including the potential impact on the length of hospital stay; however, the correlation between anemia severity and hospitalization duration in pulmonary TB patients remains unclear. This study aimed to determine the correlation between hemoglobin levels and length of hospital stay among pulmonary tuberculosis patients at Rumah Sakit Islam Purwokerto. An analytic observational study with a cross-sectional approach was conducted using medical record data of hospitalized pulmonary TB patients who met the inclusion criteria. Hemoglobin levels were categorized into mild, moderate, and severe anemia, while length of hospital stay was classified as short (≤5 days) and prolonged (>5 days) based on the third quartile (Q3). Bivariate analysis using the Fisher-Freeman-Halton Exact test showed no significant correlation between hemoglobin levels and length of hospital stay (p = 0.123), which was consistent with multivariate logistic regression analysis after adjustment for potential confounding variables (p = 0.172). In conclusion, hemoglobin levels were not significantly associated with length of hospital stay, suggesting that hospitalization duration is influenced by multiple factors and not solely determined by anemia severity. Keywords: Pulmonary Tuberculosis, Hemoglobin, Anemia, Length of Hospital Stay.
Effect of a Single Hemodialysis Session on Platelet Count, Lymphocyte Count, and Platelet-to-Lymphocyte Ratio in Hospitalized Patients with Chronic Kidney Disease Desinta Farah Putri Hartanto; Ratna Wulan Febriyanti; Yusuf Adi Gunawan; Mohammad Nurrizki Haitamy
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol. 9 No. 2 (2026): Herb-Medicine Journal October 2026
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v9i2.30967

Abstract

Chronic Kidney Disease (CKD) stage V is the final stage of kidney disease that requires kidney replacement therapy in the form of hemodialysis. Hemodialysis is known to trigger a systemic inflammatory response that potentially affects hematological parameters, including the Platelet-to-Lymphocyte Ratio (PLR). This study aims to determine the effect of hemodialysis on changes in platelet count, lymphocyte count, and PLR in hospitalized patients with stage V CKD at Purwokerto Islamic Hospital. This analytical study used a retrospective observational design with a paired pre–post design and involved 45 adult patients (≥18 years) with stage V CKD who underwent routine hemodialysis twice per week for 4-5 hours per session at RSI Purwokerto. Data on platelet count, lymphocyte count, and PLR values before and after one hemodialysis session were obtained from medical records. The normality of the data was tested using the Shapiro– Wilk test. A paired t-test was used for data that were normally distributed, while the signed-rank Wilcoxon test was used for data that were not normally distributed, with a significance level of p <0.05. A total of 45 patients met the study criteria. The average platelet count changed from 264.53±145.10 ×10³/μL before hemodialysis to 264.33±125.48 ×10³/μL after hemodialysis (p=0.133). The average lymphocyte count increased from 11.42±7.93 to 12.50±13.56 (p=0.488). The average PLR increased from 39.99±55.88 before hemodialysis to 44.90±53.24 after hemodialysis, but the difference was not statistically significant (p=0.692). In conclusion, one hemodialysis session did not have a significant effect on platelet count, lymphocyte count, or PLR values in stage V CKD patients. These findings suggest that PLR more reflected chronic inflammatory processes than acute hematological changes after one hemodialysis session.
Co-Authors Desinta Farah Putri Hartanto Endang Sri Lestari Mohammad Nurrizki Haitamy Mujahidah Mujahidah Mustika Ratnaningsih Purbowati Purnomo Hadi Puti Taqwa Rizka Adi Nugraha Putra V. Rizke Ciptaningtyas Winarto Winarto Yusuf Adi Gunawan