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All Journal Majalah Patologi Indonesia
Ibnu Alferraly
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Health Professions Public Health

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Hubungan Ekspresi Imunohistokimia p16INK4a terhadap subtipe dan grading histopatologi pada karsinoma sel skuamosa penis Marisi Cintya Debby Sihotang; T. Kemala Intan; Ibnu Alferraly; Causa Trisna Mariedina; Joko S. Lukito
Majalah Patologi Indonesia Vol. 35 No. 2 (2026): Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.687

Abstract

Background Penile squamous cell carcinoma is a malignancy of the epithelial cells of the prepuce or glans penis, occupying 95% of all malignancies in the penis.The average patient age is 50 until 70 years. The p16INK4a immunohistochemistry is a cyclin dependent kinase inhibitor and can be expressed by human papilloma virus. Several studies have tried to relate this expression to eradicate this virus.  Methods This study use cross-sectional analytical study with 30 samples of histopathological preparations diagnosed as penile squamous cell carcinoma at H. Adam Malik Hospital Medan. Assessment of p16INK4a expression was made based on analysis of the percentage of positive tumor cells and staining intensity. Score 0: (no positive tumor cells). Score +1: (≤10% positive tumor cells). Score +2: (11–50% positive tumor cells). Score +3: (> 50% positive tumor cells). The color intensity of p16INK4a  is categorized as follows:  Score 0: (negative). Score 1: (weak). Score 2: (strong). Results The most common age was 40-49 years, the most location was in more than one region, the most subtype was HPV-associated ,the most weak positive expression was the HPV-associated subtype and the most strong positive expression was HPV-associated of squamous cell carcinoma of penile. The highest immunohistochemical expression of p16INK4a  was weakly positive at grade 3. Conclusion There is a significant relationship between p16INK4a and histopathological subtypes, but there was no significant with the grading of penile squamous cell carcinoma.    
The Relationships between p16INK4a Immunohistochemistry Expression with Histopathological Subtypes in Cervical Adenocarcinoma. Sarah Adila; Ibnu Alferraly; Jessy Chrestella; Joko S. Lukito; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol. 35 No. 2 (2026): Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.690

Abstract

Background Cervical adenocarcinoma is one of the epithelial malignancies that frequently occurs in the cervix after squamous cell carcinoma. The association between human papillomavirus (HPV) and cervical carcinoma is well known, with HPV being identifiable in almost all cervical squamous carcinomas. Research on HPV in cervical adenocarcinoma is less extensive but generally suggests a significant association. p16INK4a, a tumor suppressor gene, serves as a marker for oncogenic HPV infection and can aid in diagnosing cervical adenocarcinoma. Methods This research cross-sectional study with 34 cases cervical of adenocarcinoma that have been diagnosed at Haji Adam Malik central Hospital, Medan, Prof. Dr. Chairuddin Panusunan Lubis Hospital, North Sumatra University, and Putri Bidadari Hospital Langkat. Histopathological subtypes were assessed using Hematoxylin and Eosin staining, followed by immunohistochemical staining for p16INK4a. The Somers' d test evaluated the relationship between p16INK4a expression and adenocarcinoma subtypes. Results The study found that among HPV-associated adenocarcinomas, 20 cases (58.8%) had strong positive p16INK4a expression, while 4 cases (11.8%) were negative. For HPV-independent adenocarcinomas, 5 cases (14.7%) had strong positive expression, 2 cases (5.9%) had weak positive expression, and 3 cases (8.8%) were negative. Statistical analysis using the Somers' d test resulted in a p-value of 0.097, indicating no significant correlation (p-value > 0.05). Conclusion No significant association was found between p16INK4a expression with histopathological subtype in cervical adenocarcinoma.
Co-Authors Delyuzar, Delyuzar Jessy Chrestella Joko S. Lukito Mariedina, Causa Trisna Marisi Cintya Debby Sihotang Sarah Adila T. Kemala Intan