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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
INHS, Cikra
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Medicine & Pharmacology

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Formulasi and Evaluasi Stabilitas Fisik Suspensi Ubi Cilembu (Ipomea batatas L.) dengan Suspending Agent CMC Na dan PGS Sebagai Antihiperkolesterol Fitriani, Yeyen Nor; INHS, Cikra; Yuliati, Ninis; Aryantini, Dyah
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.887 KB) | DOI: 10.33508/jfst.v2i1.699

Abstract

Drug which has small solubility in water is one of the problems that cause instability of pharmaceutical preparations. One drug practically insoluble in water is cilembu (Ipomoea batatas L.). So cilembu (Ipomoea batatas L.) made in form of suspension in order to produce stable preparations in liquid form. Making of the suspension cannot be separated from the suspending agent. CMC Na (Carboxymethylcellulose Sodium) and PGS (pulvis gummosus) is suspending agent which have been studied to produce a stable suspension. Accordingly, this study was conducted to know the suspension evaluation stability cilembu (Ipomoea batatas L.) with a suspending agent CMC Na and PGS as antihypercholesterol. Method of manufacture is dispersion method. Evaluation of physical stability test was conducted on the organoleptic, homogeneity, pH, density, viscosity, sedimentation volume, and redispersion. Data were analyzed with repeated measures and shelflife. Evaluation of physical stability the suspension cilembu with a suspending agent CMC Na and PGS on observations organoleptic, homogeneity, density and redispersion showed no difference, while the pH, viscosity and sedimentation volume were not significant differences (p< 0.05) during 30 days of storage.
Formulasi and Evaluasi Stabilitas Fisik Suspensi Ubi Cilembu (Ipomea batatas L.) dengan Suspending Agent CMC Na dan PGS Sebagai Antihiperkolesterol Fitriani, Yeyen Nor; INHS, Cikra; Yuliati, Ninis; Aryantini, Dyah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.699

Abstract

Drug which has small solubility in water is one of the problems that cause instability of pharmaceutical preparations. One drug practically insoluble in water is cilembu (Ipomoea batatas L.). So cilembu (Ipomoea batatas L.) made in form of suspension in order to produce stable preparations in liquid form. Making of the suspension cannot be separated from the suspending agent. CMC Na (Carboxymethylcellulose Sodium) and PGS (pulvis gummosus) is suspending agent which have been studied to produce a stable suspension. Accordingly, this study was conducted to know the suspension evaluation stability cilembu (Ipomoea batatas L.) with a suspending agent CMC Na and PGS as antihypercholesterol. Method of manufacture is dispersion method. Evaluation of physical stability test was conducted on the organoleptic, homogeneity, pH, density, viscosity, sedimentation volume, and redispersion. Data were analyzed with repeated measures and shelflife. Evaluation of physical stability the suspension cilembu with a suspending agent CMC Na and PGS on observations organoleptic, homogeneity, density and redispersion showed no difference, while the pH, viscosity and sedimentation volume were not significant differences (p< 0.05) during 30 days of storage.
Penetapan Kadar Hidrokuinon pada Krim Pemutih Wajah A dan B dengan Metode Kolorimetri Dian M., Lailul; INHS, Cikra
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.808

Abstract

Hidrokuinon adalah bahan aktif yang dapat mengendalikan produksi pigmen yang tidak merata, tepatnya berfungsi untuk mengurangi atau menghambat pembentukan melanin kulit. Penggunaan hidrokuinon sebagai bahan tambahan krim pemutih kulit yaitu dengan kadar kurang dari 2%. Pemakaian hidrokuinon yang berlebih memberikan efek samping yang sangat merugikan. Penelitian ini bertujuan untuk mengetahui apakah terdapat kandungan hidrokuinon yang berlebih dalam sampel krim pemutih wajah A dan B. Analisis hidrokuinon dalam sampel krim dilakukan dengan metode kolorimetri menggunakan pereaksi floroglusin dan pengukuran serapan dengan spektrofotometri UV-Vis. Analisis data dilakukan dengan Independent Samples T Test pada taraf uji 5%. Hasil penetapan kadar dari sampel krim A dan krim B secara berurutan adalah 0,404±0,436 mg/L dan 0,872±0,000 mg/L. Sampel krim pemutih wajah B menunjukkan kadar hidrokuinon terbesar (0,872±0,000 mg/L) dan persentase kadar hidrokuinon yang diperoleh adalah 0,35%. Hasil data uji statistik dengan menggunakan Independent Samples T Test dapat diketahui bahwa dari setiap sampel krim pemutih wajah mempunyai perbedaan kadar yang bermakna antarkelompok sampel krim dengan nilai signifikan p=0,032 (p
Co-Authors Dian M., Lailul Dyah Aryantini, Dyah Fitriani, Yeyen Nor Ninis Yuliati, Ninis