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All Journal Althea Medical Journal An Idea Health Journal
Rezano, Andri
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Penile Length of Prepubertal Children in Surabaya Susiana, Okta Margarita; Yuliawati, Tri Hartini; Purwanto, Bambang; Rezano, Andri; I’tishom, Reny
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.3094

Abstract

Background: Early recognition of phallic size abnormalities is essential to identify underlying endocrine and genetic disorders. Parents are concerned regarding their son’s penis length, especially obese and short-stature boys. This study aimed to investigate the factors of penile length in prepubertal boys aged 9-11 in Surabaya.Methods: A cross-sectional analytic observational study was conducted between October and November 2021 during the community services program of the Andrology Study Program, Universitas Airlangga. One hundred forty-eight healthy boys aged 9-11 years were enrolled in this study. Penile parameters and anthropometric measures were recorded. Data were analyzed with Spearman Rho’s formula to correlate the variables studied.Results: The average penile lengths and penile circumference of the penis were 6.3±1.4 and 5.2±1.0 cm, respectively. This study found two boys with micropenis (1.35%) with normal and overweight body mass index (BMI). The penile length was positively correlated with height but not with BMI.Conclusion: Androgen and growth hormones significantly influence penile length. Children with abnormal BMI tend to have smaller penile sizes, associated with increasing androgen aromatization.
Ethanol Extract of Pomegranate Peel (Punica Granatum) in Inhibiting HeLa Cell Proliferation Nurfazriah, Latifah Rahman; Dhianawaty, Diah; Rezano, Andri; Edwinanto, Ludovicus
An Idea Health Journal Vol 4 No 01 (2024)
Publisher : PT.Mantaya Idea Batara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53690/ihj.v4i01.445

Abstract

Cervical cancer is one of the causes of death in women in Indonesia. Many studies have been conducted to determine the anti-cancer effects of natural ingredients. Pomegranate peel contains ellagic acid which has anti-cancer effects. In this study, the anti-cancer activity of pomegranate peel was examined against HeLa cell lines. Pomegranate peel was obtained from Malang, East Java, extracted using 70% ethanol. Cell viability and IC50 values were examined using the MTT test after incubation for 24, 48, and 72 hours. The percentage of living cells was calculated using a hemocytometer using Trypan Blue staining. DNA fragmentation was examined using electrophoresis as a marker of apoptosis activation. The IC50 value in pomegranate peel extract was at a concentration of 450 µg/ml. The results of the percentage of viability cells using hemocytomete at an IC50 concentration of 52%. Smears in DNA fragmentation examination were seen in samples incubated for 24 hours, indicating apoptosis activation. Pomegranate peel extract has anticancer activity against HeLa cell lines, with a mechanism involving apoptosis. This potential indicates that pomegranate peel extract can be further developed as a natural anticancer agent
Co-Authors Bambang Purwanto Diah Dhianawaty Edwinanto, Ludovicus I’tishom, Reny Nurfazriah, Latifah Rahman Susiana, Okta Margarita Yuliawati, Tri Hartini