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All Journal Journal Pharmasci (Journal of Pharmacy and Science)
Lamtiur Nainggolan
Akademi Farmasi Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Effect Of Isopropyl Palmitate Composition As Liquid Lipid On The Physical Characteristics Of Nanostructured Lipid Carrier (NLC) Coenzyme Q10: Pengaruh Komposisi Isopropyl Palmitat sebagai Lipid Cair terhadap Karakteristik Fisik Sediaan Nanostructured Lipid Carrier (NLSC) Koenzim Q10 Silvi Ayu Wulansari; Lamtiur Nainggolan; Denis Alifia Azzahro; Azka Nur Khoirun; Andhika Dwi Aristyawan
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 1 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i1.540

Abstract

Coenzyme Q10 is naturally found in mitochondria, functioning as an antioxidant to protect the body from free radicals. One preparation that can increase its stability is Nanostructured Lipid Carrier (NLC). NLC is a drug delivery system that uses a combination of solid lipids and liquid lipids stabilized by surfactants. This study aims to determine the composition of Isopropyl palmitate on the physical characteristics of the NLC Coenzyme Q10 preparation. In this study, the formulation of NLC Coenzyme Q10 preparation was made with varying concentrations of liquid lipids Isopropyl palmitate F1 2%, F2 3% and F3 4% solid lipid Cetyl palmitate 12% with the active ingredient Coenzyme Q10. The finished NLC preparation was stored for 24 hours to conduct physical characteristic tests including organoleptic tests, homogeneity, pH, and spreadability. Based on the results of organoleptic testing, the three formulas have met the specified specifications, namely having a semi- solid form, pale yellow in color and odorless, and showing good homogeneity. The test results showed that variations in the composition of isopropyl palmitate did not significantly affect the pH value or spreadability of the NLC coenzyme Q10 preparation (p>0.05). Based on the results of this study, it can be concluded that differences in the composition of liquid lipids in the NLC Coenzyme Q10 preparation did not affect the physical characteristics test.
Co-Authors Aristyawan, Andhika Dwi Azka Nur Khoirun Denis Alifia Azzahro Wulansari, Silvi ayu