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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Jurnal Pengabdian Kepada Masyarakat Itekes Bali Borneo Journal of Pharmacy IJENSET
Aristyawan, Andhika Dwi
Akademi Farmasi Surabaya
Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Uji In Vitro Interaksi Cefadroxil dengan Pisang dan Susu terhadap Bakteri Staphylococcus aureus dengan Metode Difusi Cakram Handayani, Widya; Dwi Aristyawan , Andhika; Ega Safitri, Octavia
Journal of Pharmacy and Science Vol. 5 No. 2 (2020): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v5i2.191

Abstract

Penelitian ini bertujuan untuk mengetahui adanya interaksi Cefadroxil dengan makanan dan minuman terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus secara in vitro. Penelitian ini dilakukan secara eksperimental kualitatif . Sebagai kontrol positif digunakan antibiotik Cefadroxil 0,01%, kontrol negatif aquadest steril, dan sampel yang digunakan pisang dan susu. Terdapat 4 perlakuan yaitu konsentrasi 10%, 20%, 40%, dan 80% dengan tiga kali pengulangan menggunakan metode difusi cakram. Uji One Way Anova dan LSD memperoleh nilai p < α (0,05) sehingga menunjukkan adanya perbedaan zona hambat pertumbuhan Escherichia coli dan Staphylococcus aureus pada berbagai konsentrasi.
Potensi Antibakteri dari Ekstrak Etanol Spons Agelas cavernosa Andhika Dwi Aristyawan; Noor Erma Sugijanto; Suciati Suciati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 4 No. 1 (2017): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.65 KB) | DOI: 10.20473/jfiki.v4i12017.39-43

Abstract

Pendahuluan: Beberapa spons dari genus Agelas telah dilaporkan memiliki aktivitas antimikroba, namun belum ada laporan tentang aktivitas antimikroba dari Agelas cavernosa. Tujuan: Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol dari spons Agelas cavernosa. Metode: Aktivitas antibakteri pada ekstrak ditentukan dengan menggunakan metode mikrodilusi terhadap Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538 dan Pseudomonas aeruginosa ATCC 27853. Pereaksi warna p-iodonitrotetrazolium chloride ditambahkan dalam sumuran untuk memvisualisasikan adanya bakteri hidup. Hasil:  ekstrak etanol dari spons A. cavernosa menghambat pertumbuhan ketiga bakteri uji dengan aktivitas antibakteri tertinggi pada Pseudomonas aeruginosa ATCC 27853 dengan MIC 150 ppm. Kesimpulan: Ekstrak ethanol A. cavernosa menunjukkan aktivitas antibakteri.
Antioxidan Activity from Methanol Extract of Kratom Leaves (Mitragyna speciosa) Maseration Result Using The DPPH Method: Aktivitas Antioksidan Ekstrak Metanol Daun Kratom (Mitragyna speciosa) Hasil Maserasi Menggunakan Metode DPPH Andhika Dwi Aristyawan; Anggi Ayu Windari; Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.357

Abstract

Antioxidants are compounds that can prevent the formation of free radicals. Kratom is a typical plant from South Putussibau area, in West Kalimantan. The kratom plant contains alkaloids, triterpenoid-steroids, saponins, tannins and flavonoids. The main component of kratom leaves is an indole alkaloid that is efficacious as an antioxidant. The goal is to determine the antioxidant activity of kratom leaf extract (Mitragyna speciosa). The method used is the measurement of the reduced amount of DPPH from an antioxidant compound UV-Vis spectrophotometrically at a wavelength of 517nm using Vitamin C as a comparison. The extraction method used is maceration. The test was sampled 10 mg of kratom leaf extract (Mitragyna speciosa) with 10 ppm, 20 ppm, 30 ppm, 40 ppm, and 50ppm concentrations, then repeated 3 times. The results of the antioxidant activity of kratom leaves (Mitragyna speciosa) were expressed with IC50 values of 44,169 ± 0.5313 with an RSD value of 1.202%. Then it can be concluded that kratom leaf methanol extract (Mitragyna speciosa) has a very strong antioxidant activity with an IC50 value of 44,169 ± 0.5313 with an RSD value of 1.202%.
SENYAWA FITOKIMIA DAN AKTIVITAS ANTI COVID STUDI IN SILICO EKSTRAK CABE JAWA (Piper retrofractum Vahl) Umarudin, Umarudin; Syafitri, Meyke Herina; Aristyawan, Andhika Dwi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1591

Abstract

Javanese chili has the potential to develop, one of which is that it contains phytochemical compounds and essential oils, which can act as antioxidants in preventing COVID-19, so it is necessary to utilize the natural potential in Indonesia, namely Javanese chili. This research aims to determine the phytochemical screening and anti-covid activity of an in silico study of Javanese chili extract. This research method carried out phytochemical screening of ethanol extracts, tested for alkaloids, flavonoids, tannins, saponins, and terpenoids, tests for determining levels of piperine, essential oils, and cavitsin, as well as in silico studies with piperine ligands with RdRP and ACE2 receptors docked with Hex.8.0.0 and visualized with discovery studio. This research shows that the phytochemical screening results of Javanese chili fruit extract are positive for containing alkaloids, flavonoids, tannins, saponins, terpenoids, piperine 3.36%. This research concludes that in silico, the Javanese chili piperine compound can bind to the active site of ACE Sarcov 2 through RdRP inhibition.
PHYTOCHEMICAL SCREENING OF ETHANOL EXTRACT 96% BLACK EAR MUSHROOM (Auricularia nigricans) BY SOXLETATION METHOD Mercyska Suryandari, Mercyska; Andhika Dwi Aristyawan, Andika; Fiska Yuliarni, Floreta; Ari Anggraini, Nony
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 3 No. 2 (2024): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

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Abstract

Black ear mushroom (Auricularia nigricans) contains useful compounds, traditionally used as medicinal ingredients and food sources. The purpose of this study was to determine the secondary metabolites are contained in the extract of black ear mushroom (Auricularia nigricans). The extraction method used in this study is soxletation method. The sample used is 200 g of black ear mushroom (Auricularia nigricans) was extracted using soxhletation method with 1 l ethanol 96 % solvent. The phytochemical screenings test uses standard reagent by observing color changes, sediment, and foam. The result of the study that the extract of black ear mushroom (Auricularia nigricans) showed a red color after being given Dragendorrf reagent, terpenoid reagent test, flavonoid reagent test, gave a green color change after being given phenolic and tannin reagent test, did not give a red color in the steroid reagent test and did not produce foam in the saponin test. The conclusion of the study that the extract of black ear mushroom (Auricularia nigricans) contained secondary metabolite compounds tannins, terpenoids, flavonoids, phenolics, and alkaloids.
Penyuluhan Penggunaan Tanaman Obat Keluarga (TOGA) Daun Binahong Sebagai Anti-Bakteri Arifiyana, Djamilah; Fandinata, Selly Septi; Aristyawan, Andhika Dwi
JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Vol 4, No 4: November (2023)
Publisher : ICSE (Institute of Computer Science and Engineering)

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Abstract

Abstrak: Gaya hidup back to nature, atau kembali ke alam saat ini semakin banyak diminati seiring dengan kesadaran masyarakat akan bahaya yang ditimbulkan dari penggunaan bahan kimia. Hal ini membuat penggunaan Tanaman Obat Keluarga (TOGA) kembali populer dikalangan masyarakat di Indonesia. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan tentang pemanfaatan dan pengolahan TOGA daun Binahong sebagai bahan alami untuk membuat sediaan yang bermanfaat bagi tubuh sebagai upaya preventif dan promotif pada musim pancaroba. Metode pelaksanaan kegiatan ini adalah melalui penyuluhan yang meliputi metode ceramah, diskusi, dan praktik langsung. Masyarakat sasaran kegiatan ini adalah warga RT 13 RW 01 Kelurahan Jagir Surabaya. Kegiatan terdiri dari beberapa tahapan, yakni Pra survey dan perizinan lokasi kegiatan, Penyuluhan tentang penyakit yang muncul saat pancaroba sekaligus penyerahan TOGA, Pemantauan pertumbuhan TOGA, Penyuluhan budidaya sederhana TOGA dan pembuatan sediaan dauh binahong, serta Evaluasi kebermanfaatan pelaksanaan kegiatan pemanfaatan daun binahong sebagai anti-bakteri. Setelah serangkaian kegiatan terlaksana, diperoleh hasil kuesioner menunjukkan bahwa 100% dari warga RT 13 RW 01 Kelurahan Jagir Surabaya setuju bahwa kegiatan ini bermanfaat dan dapat diikuti dengan jelas dan baik, 97,06% setuju bahwa kegiatan ini dapat diterapkan dalam kehidupan sehari-hari, serta 100% warga setuju untuk mengaplikasikan pembuatan pestisida alami di rumah dan menyatakan bahwa bahan yang dibutuhkan dalam pembuatannya mudah didapatkan.Abstract: ‘Back to nature’ lifestyle is currently increasing in demand along with public awareness of the dangers posed by the use of chemicals. This has made the use of Tanaman Obat Keluarga (TOGA) popular again among people in Indonesia. This community service activity aims to increase knowledge about the use and processing of TOGA Binahong leaves as a natural ingredient for making preparations that are beneficial for the body as a preventive and promotive effort during the transition season, as well as providing education about TOGA cultivation in a simple way. The method for implementing this activity is through counseling which includes lecture, discussion and direct practice methods. The target community for this activity are residents of RT 13 RW 01, Jagir, Surabaya. The activity consists of several stages, namely Pre-survey and licensing of activity locations, Counseling about diseases that appear during the transition as well as handing over TOGA, Monitoring the growth of TOGA, Counseling on simple cultivation of TOGA and making binahong leaf preparations, as well as Evaluation of the usefulness of implementing activities to use binahong leaves as an anti-bacteria. After a series of activities were carried out, the results of the questionnaire showed that 100% of the residents of RT 13 RW 01, Jagir Subdistrict, Surabaya agreed that this activity was useful and could be followed clearly and well, 97.06% agreed that this activity could be applied in their daily life, and 100% of residents agreed to apply natural pesticide production at home and stated that the materials needed to make it were easy to obtain.
UU Edukasi Herbal 3S (Salam, Seledri, Dan Sirsak) Sebagai Terapi Antihiperkolesterolemia Di Smk Farmasi Surabaya Umar, Umarudin; Suryadari, Mercyska; ., Surahmaida; Kusumo, Galuh Gondo; Ulfa, Ninik Mas; Aristyawan, Andhika Dwi; ., Syukrianto
Jurnal Abdimas ITEKES Vol 4 No 1 (2024)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Institute Teknologi dan Kesehatan (ITEKES) Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37294/jai.v4i1.568

Abstract

Dampak buruk dari hiperkolesterolemia tidak hanya pada orang tua namun karena life style banyak anak-anak mengalami hiperkolestrolemia. Upaya yang dilakukan berdsarkan hasil wawancara dengan mengkonsumsi obat sintesis namun memiliki efek samping dan perlu upaya alternatif dengan memanfaatkan potensi herbal yang ada disekitar lingkungan yaitu 3S (Salam, Seledri dan Sirsak). Banyak penelitian yang menunjukkan bahwa daun salam dapat menurunkan kadar kolesterol baik berupa ekstrak maupun berupa minuman yaitu air rebusan dan jus daun salam.  Seledri dapat menurunkan kadar kolesterol atau sebagai terapi alternatif untuk antihipekolesterolemia. Sirsak sudh banyak diterapkan sebagai penurun kolesterol dengan cara direbus. Tujuan kegiatan ini adalah memberikan edukasi potensi 3S (Salam, Seledri dan Sirsak) sebagai terapi antihiperkolesterolemia, dimana nantinya dapat bermanfaat untuk masyarakat khususnya para remaja yang rentan terhadap penyakit degenerative. Metode pendekatan dengan penyuluhan dan edukasi. Kegiatan pengmas di hadiri oleh 30 siswa SMK Farmasi Surabaya dilakukan bulan 30 Januari 2024. Kegiatan pengmas ini dengan media edukasi powerpoint tentang pengetahuan antihiperkolestrolemia, terapi secara non farmakalogi 3S dengan potensi kandungan senyawa kimia  seperti flavonoid, tanin, dan minyak atsiri. Kandungan tersebut berpotensi untuk menurunkan antihiperkolestrolemia. Tingkat pengetahuan hasil pre test sebesar  57% dan post test menunjukan peningkatan tingkat pengetahuan siswa terhadap 3S sebagai terapi non farmaklogis antihiperkolestrolemia sebesar 97%. Kata kunci : antihiperkolestrolemia, 3S (Salam, seledri, dan sirsak), Non farmakalogi
EFFECT OF EXTRACTION METHOD ON DETERMINING TOTAL PHENOL CONTENT OF ROSEMARY EXTRACT Mercyska Suryandari, Mercyska; Dwi Aristyawan, Andhika; Wefa, Ali; Ngurah Rio Juliana, I Made
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 4 No. 1 (2025): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v4i1.120

Abstract

Rosemary is a unique herb that is commercially available for use as an antioxidant. On the other hand, it can also be used as a food preservative, as it prevents oxidation and microbial contamination. Therefore, rosemary can be useful for replacing or even reducing synthetic antioxidants in food. Antioxidants are compounds that can inhibit oxidation reactions, by binding free radicals and molecules very effectively. As a result, cell damage will be inhibited. Known sources of antioxidants can be synthetic antioxidants and natural antioxidants originating from compounds contained in plants, one of which is phenolic compounds. To obtain phenolic compounds, extraction is carried out using maceration and digestion methods. The solvent choice here uses 80% ethanol solvent. The results obtained in this study were that 80% ethanol extract of rosemary was extracted using the maceration method, with a total phenol content of 11.84 mg GAE/g extract, while using digestion the total phenol content was 9.61 mg GAE/g extract. It can be concluded that the extraction method can influence the results of total phenol content with a significant difference with a p value <0.05
ANTIOXIDANT TESTING OF MANGGO CONSTRAINT LEAVES EXTRACT (DENDROPHTHOE PENTANDRA) DEKOKTA RESULTS Umarudin; Octifany, Salsabila; Kusumo, Galuh Gondo; Aristyawan, Andhika Dwi; Yuliarni, Floreta Fiska; Renaisansa, Ramadhan; Pertiwi, Husadhani Dwi
Indonesian Journal of Engineering, Science and Technology Vol. 2 No. 1 (2025): VOL. 02 NO. 01 (JUNE 2025)
Publisher : Universitas Muhammadiyah Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38040/ijenset.v2i1.1232

Abstract

Mango mistletoe leaves have been identified as a natural source of antioxidants because they contain the quarcetin. The aim of this research is to determine whether mango mistletoe Dendrophthoe pentandra leaf extract extracted using the dekokta method has antioxidant activity if tested using the DPPH method. This research was carried out by extracting samples of mango mistletoe leaf powder Dendrophthoe pentandra using the  decoction method, the extract obtained was tested for antioxidant activity using the DPPH method using UV-Vis spectrophotometry with a comparison in the form of vitamin C. The results of the mango mistletoe leaf extract was tested at a wavelength of λ 521.5 nm obtained with an IC50 value of 322.80 ppm, with SD ± 107.08 and RSD 33.17%. while for ascorbic acid the IC50 value was 53.89 ppm, with SD ± 6.39 and RSD 11.86%. This research can be concluded that the dekokta mango mistletoe leaf extract has very weak antioxidant activity while ascorbic acidhas relatively strong antioxidant activity. It would be advisable to measure the levels of secondary metabolites contained in the extract of mango mistletoe and it is necessary to carry out research on the antioxidant activity of mistletoe mango leaf extract using methods other than the DPPH method.   Keywords: Antioxidants; Decoction; Dendrophthoe pentandr; DPPH.
Granulation Methods Dependent Physical Characteristics of Chitosan Effervescent Granule Suspension from Mangrove Crab (Scylla serrata) Shell Imtihani, Hilya Nur; Isbandyah, Nimas Ajeng; Susanti, Endah; Aristyawan, Andhika Dwi
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.7334

Abstract

The mangrove crab (Scylla serrata), a prevalent resource in coastal mangrove ecosystems, is widely utilized for consumption. Its shell offers a valuable source of chitosan, a biopolymer readily synthesized and recognized for its potential health benefits. Chitosan's unique structure, characterized by the presence of amine groups, imparts a strong positive charge, enabling it to effectively bind with negatively charged molecules such as oils and fats. This property makes chitosan a promising natural compound for managing cholesterol levels. Developing a palatable and convenient dosage form, such as an effervescent granule suspension, is crucial to enhance its public acceptance as a health supplement. This study investigated how different granulation methods (wet and dry) influence the physical properties of effervescent granules containing chitosan, both before and after reconstitution. Four distinct formulations were prepared: F1 and F2 employed dry and wet granulation, respectively, with a citric acid : tartaric acid ratio of 10% : 20%; while F3 and F4 utilized the same granulation methods but with a higher acid ratio of 13% : 26%. Comprehensive evaluation revealed that all formulations generally met quality requirements, except F3's pH (4.38 ± 0.57). Statistical analysis using an independent sample t-test indicated that the granulation method significantly affected parameters such as flow time, percentage of fines, dispersion time, and pH. Ultimately, the dry granulation method yielded the most favorable characteristics, with Formula I (F1) exhibiting superior flow properties, optimal pH, and desired viscosity.
Co-Authors ., Syukrianto Anggi Ayu Windari Ari Anggraini, Nony Djamilah Arifiyana Ega Safitri, Octavia Endah Susanti, Endah Galuh Gondo Kusumo Imtihani, Hilya Nur Isbandyah, Nimas Ajeng Kusumo, Galuh Gondo Mercyska Suryandari Mercyska Suryandari, Mercyska Ngurah Rio Juliana, I Made Noor Erma Sugijanto Octifany, Salsabila Pertiwi, Husadhani Dwi Renaisansa, Ramadhan Septi Fandinata, Selly Suciati Suciati Surahmaida, Surahmaida Suryadari, Mercyska Syafitri, Meyke Herina Ulfa, Ninik Mas Umar, Umarudin Umarudin Umarudin, Umarudin Wefa, Ali Widya Handayani Yuliarni, Floreta Fiska