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Iwan Dwi Prahasto

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Author-ID : 1157365

Dentistry

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ADDITIONAL OF CHEMICAL ENHANCER FOR INCREASING THE PENETRATIONAL FLUORIDE MOUSE SKIN: PENAMBAHAN BAHAN KIMIA UNTUK PENINGKATAN DAYA TEMBUS ION FLUORIDA PADA KULIT TIKUS Diyah Fatmasari; Iwan Dwi Prahasto; Akhmad Kharis Nugroho; Widjijono
Dentika: Dental Journal Vol. 17 No. 1 (2012): Dentika Dental Journal
Publisher : TALENTA

Fluoride plays an important roles in reducing dental caries by improving remineralization process and strengthening emailthrough forming fluoroapatite which is more resistant to acid. Fluoride systemic mode without passing metabolism withsmall and controlled dose need to be developed such as Transdermal route. The aims of this research was to find iffluoride solution with and without enhancer solution is able to penetrate to skin. Quasy experimental design with post testonly control group design as research approach was used. Transport test with Franz Like Diffusion cell used as theinstrument in vitro skin permeation test with hairless and full thickness mouse skin as membrane between donor andrecipient cell. Two groups of donor cell was fluoride solution and fluoride added with chemical enhancer: oleic acid andiso propyl alcohol (IPA) solution and recipient solution was CMF PBS 0,1 M pH 7,4. Control group was oleic acidsolution. Sample was taken for time interval of 4, 20 and 24 hours and Fluoride containt was measured by PotensiometerSpesific Ion Fluoride. The results showed that there was an influence of transport test both on NaF solution andNaF+oleat acid and IPA solution (p= 0.00) and (0.00) on fluoride permeation, however there was no significant differenceon control group (p= 0.07). NaF added with chemical enhancer solution and it had higher penetrating power than othersolution. It can be concluded that added chemical enhancer can increase the penetration of fluoride.

PENGARUH RISEDRONATE BISPHOSPHONATE TERHADAP ENZIM TRAP (EKSPRESI OSTEOKLAS) DI SEKITAR SUBSTRUKTUR IMPLAN GIGI ENDOSSEOUS: EFFECT OF RISEDRONATE BISPHOSPHONATE ON ENZYM TRAP (OSTEOCLAST EXPRESSION) SURROUNDINGS SUBSTRUCTURE ENDOSSEOUS DENTAL IMPLANT Suparyono Saleh; Iwan Dwi Prahasto; Munakhir Mudjosemedi; Ika Dewi Ana
Dentika: Dental Journal Vol. 18 No. 1 (2014): Dentika Dental Journal
Publisher : TALENTA

Keberhasilan gigi tiruan tanam, tergantung pada proses oseointegrasi, yaitu suatu hubungan langsung antara bagianimplan gigi yang tertanam di dalam tulang rahang (substructure) dengan jaringan tulang disekitarnya tanpa ada pengaruhdari jaringan lunak yang lain. Osteoklas berperan penting dalam proses oseointegrasi karena sel tersebut mempunyaikemampuan untuk meresorpsi tulang. Tujuan penelitian ini untuk mengetahui pengaruh sediaan farmasi Risedronate(Ris) yang mempunyai kemampuan untuk mencegah proliferasi osteoklas. Tiga puluh enam tikus Wistar berumur 9-10minggu dengan berat antara 280-300 gram dibagi menjadi 4 kelompok (n= 9), setiap kelompok dibagi lagi menjadi 3subkelompok (n= 3). Kelompok I sebagai kontrol dengan perlakuan injeksi 0,05 mL cairan 0,9% NaCL sementarakelompok II, III, dan IV diinjeksi 0,05 mL sediaan Ris dengan konsentrasi 250, 500, dan 1000 Âµmol/L secara berurutan.Injeksi dilakukan setiap 3 hari sekali dengan lama waktu pemberian injeksi yang berbeda-beda, yaitu 14, 28, dan 56 hari.Analisis statistik menggunakan Uji Kruskal-Wallis dan U Mann-Whitney. Hasil penelitian menunjukkan terdapatperbedaan yang bermakna pada kelompok dosis Ris (p< 0,05) dan tidak signifikan pada kelompok hari amatan (p> 0,05).

Co-Authors Akhmad Kharis Nugroho Diyah Fatmasari Ika Dewi Ana Munakhir Mudjosemedi Suparyono Saleh W. Widjijono

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