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EKSPRESI INTERLEUKIN -1 ALFA (IL-1α) PADA HIPERSENSITIF KONTAK AKIBAT TONGUE PIERCING: INTERLEUKIN - 1 ALFA EXPRESSION IN CONTACT HIPERSENSITIVITY CAUSED BY TONGUE PIERCING Ananta Herachakri; Feby Aryani; Afrini Puspita; Hendri Susanto; Sri Hadiati
Dentika: Dental Journal Vol. 16 No. 1 (2011): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.502 KB) | DOI: 10.32734/dentika.v16i1.1903

Abstract

Tongue piercing is increasingly used by teenagers lately. Studies have reported the tongue piercing's side effects on oral health such as poor oral hygiene, too th and periodontal destruction and taste bud destruction. Tongue piercing may cause hypersensitivity which may be caused by the components of tongue piercing. Interleukin (IL)-1α expression may increase in sensitization and elicitation phase of contact hypersensitivity. The aim of this study was to know the IL-1α expression induced b y tongue piercing. This study used fifteen two-months year old male Wistar rat (Rattus norvegicus) which was divided into two group, control group treated by vaseline (I) and treatment group. Treatment group divided into three groups, named tongue piercing treatment until sensitization phase (IIA), elicitation phase for 24 hours (IIB), and 48 hours (IIC). Inteleukin- 1α expression using immunohistochemistry (IHC) staining from tissue specimen was taken from the tongue. The result of this study showed that IL- 1α expression in sensitization phase was higher than elicitation phase and was a significant difference of IL-1α expression between sensitization and elicitation phase (p<0,05). LSD test result showed there was a significant difference between sensitization phase and 24 hours elicitation phase, between sensitization phase and 48 hours elicitation phase. In conclusion, there was a difference of IL-1α expression between sensitization and elicitation phase of contact hypersensitivity induced by tongue piercing.
RANCANG BANGUN MENARA REFLUKS PADA DESTILATOR BIOETHANOL KAPASITAS 5 LITER/JAM BERSKALA UMKM Hendri Susanto; Rochmad Winarso; Rianto Wibowo
JURNAL CRANKSHAFT Vol 1, No 1 (2018): Jurnal Crankshaft Vol.1 No.1 September 2018
Publisher : Universitas Muria Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24176/crankshaft.v1i1.2588

Abstract

Bioethanol merupakan energi terbarukan yang berasal dari bahan dasar nabati. Sebagaimana fungsinya, bioethanol diharuskan memiliki tingkat kemurnian sesuai dengan standar mutu yang telah ditentukan sebagai energi terbarukan. Untuk mencapai keketentuan tersebut, telah dilakukan proses rancang bangun menara refluks pada destilator bioethanol pada saat proses kondensasi berlangsung. Metode yang digunakan pada penelitian ini adalah berupa studi literatur terhadap artikel terkait, proses perencanaan design, perancangan dan pembuatan terhadap komponen – komponen penyusun dari menara refluks, serta proses pengujian mesin untuk mengetahui fungsi kerja dari menara refluks pada destilator bioethanol. hasil penelitian menunjukkan menara refluks dapat digunakan sebagai proses kondensasi pada siklus destilasi bioethanol. Dengan dimensi shell berdiameter114 mm dan tinggi 2000 mm, dimensi tube berdiameter 94 mm dan tinggi total coil 400 mm dengan jarak antar coil 40 mm. dan dihasilkan kapasitas produksi ethanol pada mesin destilator bioethanol seabnyak 2,35 liter dengan kadar kemurnian 91%.
Peran Ekstrak Etanol Kulit Manggis (Garcinia mangostana L.) Dalam Menginduksi Apoptosis Sel Kanker Lidah Manusia Sp-C1 In Vitro SUPRIATNO -; HENDRI SUSANTO; SRI BUDIARTI
Indonesian Journal of Cancer Vol 7, No 4 (2013): Oct - Dec 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v7i4.309

Abstract

Sel kanker lidah mempunyai karakteristik pertumbuhan sel yang cepat, invasi, dan metastasis yang tinggi. Penatalaksanaan untuk kanker primer, metastasis, dan residif masih menunjukkan hasil yang belum memuaskan sehingga dipikirkan untuk mengombinasi dengan terapi pengobatan alternatif menggunakan bahan alam kulit manggis (Garcinia mangostana L.). Tujuan penelitian menguji induksi apoptosis sel kanker lidah Sp-C1 menggunakan ekstrak etanol kulit manggis in vitro. Induksi apoptosis sel pasca-perlakuan ekstrak etanol kulit manggis konsentrasi 0, 2,5, 5, 7,5, 10, dan 12,5 ?g/ml dilakukan menggunakan uji kolorimetrik caspase-3 dan -9 (DVED-pNA dan LEHD-pNA). Data dianalisis menggunakan Anova satu jalur, dilanjutkan dengan uji Post-hoc LSD dengan derajat kemaknaan 95%. Hasil penelitian menunjukkan ekstrak etanol kulit manggis konsentrasi 12,5 ?g/ml menginduksi apoptosis sel kanker lidah manusia Sp-C1 melalui aktivitas proteolitik caspase-3 dan caspase-9 (P=0,001). Peningkatan kelipatan aktivitas proteolitik caspase-3 dan -9 diketahui sebesar 1,39 dan 2,15 kali lipat. Kesimpulannya, ekstrak etanol kulit manggis dapat menginduksi apoptosis sel kanker lidah manusia Sp-C1.Kata Kunci: sel kanker lidah Sp-C1, kulit manggis, apoptosis, caspase-3 dan -9.
FACTORS RELATED TO THE IMPLEMENTATION OF NURSE HANDOVER IN THE INTERNAL MEDICINE WARD AT RSUD (REGIONAL PUBLIC HOSPITAL) PROF. DR. MARGONO SOEKARJO, PURWOKERTO Hendri Susanto; Meida Laely Ramdani; Endiyono; Yektiningtyastuti
Nursing Sciences Journal Vol 9 No 1 (2025): April 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/nsj.v9i1.6546

Abstract

  The nurse handover is a technique for conveying and receiving information about patients in the most effective manner possible, involving brief, clear, and comprehensive explanations of independent nursing actions, collaborative actions that have been or need to be undertaken, and patient progress. Several factors influence the implementation of nurse handovers, including age, education level, work experience, knowledge, responsibility, communication, documentation, leadership of the head nurse, peer support, resources, nurse motivation, nurse attitudes, and coworker relationships. Objective: To identify factors related to the implementation of nurse handover. This study used a descriptive correlational quantitative method with a cross-sectional approach, employing the chi-square test. Data collection was conducted using total sampling with a questionnaire instrument distributed to 57 respondents. Results: The Chi-Square test with a significance level of 0.05 showed the following p-values for each factor: age (p = 0.005), education level (p = 0.008), work experience (p = 0.004), knowledge (p = 0.001), responsibility (p = 0.001), documentation (p = 0.000), and communication (p = 0.002). These results indicate significant correlation between age, education level, work experience, knowledge, responsibility, communication, and documentation, and the implementation of nurse handovers. Conclusion: Age, education level, work experience, knowledge, responsibility, communication, and documentation are significantly related to the implementation of nurse handovers.