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All Journal Indonesian Journal of Biological Pharmacy
Aliya, Najma
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Unveiling the Antidiabetic Mechanism of Alpinia galanga: A Molecular Docking Approach on PPARγ Justin, Felix; Aliya, Najma; Aziz, Syarif Rahmat; Sabiila, Annisa Ahda; Ismail, Dzava Prawinsyah Fairus; Mahardika, Bintang Satrio; Novitasari, Dhania
Indonesian Journal of Biological Pharmacy Vol 6, No 1 (2026): IJBP
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v6i1.69277

Abstract

Alpinia galanga (L.) Willd., commonly known as galangal, is a medicinal plant traditionally used to manage metabolic disorders, including diabetes. Galangal rhizome contains diverse bioactive compounds with reported antioxidant, anti-inflammatory, and glucose-regulating properties, suggesting its potential as a natural antidiabetic agent. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor that plays a central role in glucose homeostasis, lipid metabolism, and insulin sensitivity, making it an important therapeutic target for type 2 diabetes mellitus (T2DM). This study aimed to evaluate the antidiabetic potential of bioactive compounds from A. galanga rhizome as PPARγ modulators using a computational-based approach. A total of 19 compounds were assessed through Lipinski’s Rule of Five, ADMETox profiling, pharmacophore screening, and molecular docking against PPARγ. Among the screened compounds, bisdemethoxycurcumin exhibited the most favorable pharmacokinetic properties and the strongest binding affinity toward PPARγ, comparable to pioglitazone. These findings indicate that bisdemethoxycurcumin from A. galanga has potential as a PPARγ-targeted antidiabetic agent and merits further experimental validation.
Co-Authors Aziz, Syarif Rahmat Dhania Novitasari Ismail, Dzava Prawinsyah Fairus Justin, Felix Mahardika, Bintang Satrio Sabiila, Annisa Ahda