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All Journal Indonesian Journal of Biological Pharmacy
Aziz, Syarif Rahmat
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Unveiling the Antidiabetic Mechanism of Alpinia galanga: A Molecular Docking Approach on PPARγ Justin, Felix; Aliya, Najma; Aziz, Syarif Rahmat; Sabiila, Annisa Ahda; Ismail, Dzava Prawinsyah Fairus; Mahardika, Bintang Satrio; Novitasari, Dhania
Indonesian Journal of Biological Pharmacy Vol 6, No 1 (2026): IJBP
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v6i1.69277

Abstract

Alpinia galanga (L.) Willd., commonly known as galangal, is a medicinal plant traditionally used to manage metabolic disorders, including diabetes. Galangal rhizome contains diverse bioactive compounds with reported antioxidant, anti-inflammatory, and glucose-regulating properties, suggesting its potential as a natural antidiabetic agent. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor that plays a central role in glucose homeostasis, lipid metabolism, and insulin sensitivity, making it an important therapeutic target for type 2 diabetes mellitus (T2DM). This study aimed to evaluate the antidiabetic potential of bioactive compounds from A. galanga rhizome as PPARγ modulators using a computational-based approach. A total of 19 compounds were assessed through Lipinski’s Rule of Five, ADMETox profiling, pharmacophore screening, and molecular docking against PPARγ. Among the screened compounds, bisdemethoxycurcumin exhibited the most favorable pharmacokinetic properties and the strongest binding affinity toward PPARγ, comparable to pioglitazone. These findings indicate that bisdemethoxycurcumin from A. galanga has potential as a PPARγ-targeted antidiabetic agent and merits further experimental validation.
Bioactive Compounds from Kaempferia angustifolia Roxb. as Potential AKT1-Targeted Anticancer Agents: In Silico Studies Saputra, Maitry; Budhiman, Muhammad Darrel Ghariza; Nedy, Meunasha Syadza; Pratama, Muhammad Hafizh Putra; Aziz, Syarif Rahmat; Anjani, Fasya Assyla; Novitasari, Dhania
Indonesian Journal of Biological Pharmacy Vol 6, No 2 (2026): IJBP
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v6i2.71568

Abstract

Cancer is characterized by uncontrolled cell growth and proliferation, often progressing to invasion and metastasis. Among the signaling cascades driving this process, the PI3K/AKT/mTOR pathway plays a central role in regulating cell survival, proliferation, and apoptosis, with the AKT1 isoform frequently implicated in oncogenic transformation through gain-of-function mutations and aberrant activation. This study evaluated the anticancer potential of bioactive compounds from Kaempferia angustifolia Rosc. (kunci pepet) as AKT1 inhibitor candidates through an integrated in silico approach, encompassing Lipinski's Rule of Five, ADMETox prediction, pharmacophore screening, and molecular docking against the AKT1 receptor. Thirty structurally diverse compounds, representing multiple secondary metabolite classes, were selected to examine how structural variation influences AKT1 binding; twenty-nine were successfully evaluated through molecular docking. Nine compounds, including flavokawain A, alpinetin, zeylenol, α-cyperone, crotepoxide, kaempferol, sandaracopimaradiene, β-sitosterol, and eleutherin, emerged as promising candidates based on favorable drug-likeness, safety profiles, and binding characteristics. Among these, zeylenol achieved the highest pharmacophore fit score (40.11) and a binding energy (−8.37 kcal/mol) surpassing the native ligand, while kaempferol showed comparable docking performance. These findings position zeylenol as the most promising AKT1 inhibitor candidate from K. angustifolia, warranting further experimental validation for anticancer drug development.
Co-Authors Aliya, Najma Anjani, Fasya Assyla Budhiman, Muhammad Darrel Ghariza Dhania Novitasari Ismail, Dzava Prawinsyah Fairus Justin, Felix Mahardika, Bintang Satrio Nedy, Meunasha Syadza Pratama, Muhammad Hafizh Putra Sabiila, Annisa Ahda Saputra, Maitry