<![CDATA[Alpinia galanga (L.) Willd., commonly known as galangal, is a medicinal plant traditionally used to manage metabolic disorders, including diabetes. Galangal rhizome contains diverse bioactive compounds with reported antioxidant, anti-inflammatory, and glucose-regulating properties, suggesting its potential as a natural antidiabetic agent. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor that plays a central role in glucose homeostasis, lipid metabolism, and insulin sensitivity, making it an important therapeutic target for type 2 diabetes mellitus (T2DM). This study aimed to evaluate the antidiabetic potential of bioactive compounds from A. galanga rhizome as PPARγ modulators using a computational-based approach. A total of 19 compounds were assessed through Lipinski’s Rule of Five, ADMETox profiling, pharmacophore screening, and molecular docking against PPARγ. Among the screened compounds, bisdemethoxycurcumin exhibited the most favorable pharmacokinetic properties and the strongest binding affinity toward PPARγ, comparable to pioglitazone. These findings indicate that bisdemethoxycurcumin from A. galanga has potential as a PPARγ-targeted antidiabetic agent and merits further experimental validation.]]>
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